Compile Data Set for Download or QSAR
Report error Found 131 Enz. Inhib. hit(s) with all data for entry = 50003869
TargetSodium-dependent serotonin transporter(Human)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50176019(SLV-314 | (R)-8-(4-(3-(5-fluoro-1H-indol-3-yl)prop...)
Affinity DataKi:  0.251nMAssay Description:Displacement of [3H]paraxetine from human 5HT transporter expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(3) dopamine receptor(Human)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50176019(SLV-314 | (R)-8-(4-(3-(5-fluoro-1H-indol-3-yl)prop...)
Affinity DataKi:  0.501nMAssay Description:Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50048803(5-[2-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-et...)
Affinity DataKi:  0.631nMAssay Description:Displacement of [3H]ketanserin from human 5HT2A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM248056(Adoprazine | 1-(2,3-dihydro-1,4-benzodioxin-5-yl)-...)
Affinity DataKi:  0.794nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50123069(2-{4-[4-(5-Fluoro-1H-indol-3-yl)-3,6-dihydro-2H-py...)
Affinity DataKi:  0.794nMAssay Description:Displacement of [3H]paraxetine from human 5HT transporter expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Human)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50176019(SLV-314 | (R)-8-(4-(3-(5-fluoro-1H-indol-3-yl)prop...)
Affinity DataKi:  0.794nMAssay Description:Displacement of [3H]spiperone from human dopamine D2 receptor short form expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(3) dopamine receptor(Human)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50123069(2-{4-[4-(5-Fluoro-1H-indol-3-yl)-3,6-dihydro-2H-py...)
Affinity DataKi:  0.794nMAssay Description:Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50001885(3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50176019(SLV-314 | (R)-8-(4-(3-(5-fluoro-1H-indol-3-yl)prop...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50001885(3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]ketanserin from human 5HT2A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50048803(5-[2-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-et...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]mesulergine from 5HT2C receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50130293(7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(4) dopamine receptor(Human)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50176019(SLV-314 | (R)-8-(4-(3-(5-fluoro-1H-indol-3-yl)prop...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]spiperone from human dopamine D4.4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50001888([3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]prazosin from adrenergic alpha1 receptor in rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50123069(2-{4-[4-(5-Fluoro-1H-indol-3-yl)-3,6-dihydro-2H-py...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50048803(5-[2-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-et...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(3) dopamine receptor(Human)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM35254(CHEMBL715 | 2-methyl-4-(4-methylpiperazin-1-yl)-10...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]ketanserin from human 5HT2A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50001885(3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]prazosin from adrenergic alpha1 receptor in rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(3) dopamine receptor(Human)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50001888([3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50048803(5-[2-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-et...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50123069(2-{4-[4-(5-Fluoro-1H-indol-3-yl)-3,6-dihydro-2H-py...)
Affinity DataKi:  2.5nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50001884(8-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b...)
Affinity DataKi:  3.20nMAssay Description:Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Human)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50123069(2-{4-[4-(5-Fluoro-1H-indol-3-yl)-3,6-dihydro-2H-py...)
Affinity DataKi:  3.20nMAssay Description:Displacement of [3H]spiperone from human dopamine D2 receptor short form expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50123069(2-{4-[4-(5-Fluoro-1H-indol-3-yl)-3,6-dihydro-2H-py...)
Affinity DataKi:  3.20nMAssay Description:Displacement of [3H]prazosin from adrenergic alpha1 receptor in rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(3) dopamine receptor(Human)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM81790(NSC_2159 | CAS_71675-85-9 | Amisulpride | US101672...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Human)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM248056(Adoprazine | 1-(2,3-dihydro-1,4-benzodioxin-5-yl)-...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]spiperone from human dopamine D2 receptor short form expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(3) dopamine receptor(Human)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50130293(7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(3) dopamine receptor(Human)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM248056(Adoprazine | 1-(2,3-dihydro-1,4-benzodioxin-5-yl)-...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Human)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]spiperone from human dopamine D2 receptor short form expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50048803(5-[2-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-et...)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM35254(CHEMBL715 | 2-methyl-4-(4-methylpiperazin-1-yl)-10...)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]mesulergine from 5HT2C receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Human)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50130293(7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}...)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]spiperone from human dopamine D2 receptor short form expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50176019(SLV-314 | (R)-8-(4-(3-(5-fluoro-1H-indol-3-yl)prop...)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50001884(8-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b...)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]ketanserin from human 5HT2A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Human)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50001885(3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin...)
Affinity DataKi:  6.30nMAssay Description:Displacement of [3H]spiperone from human dopamine D2 receptor short form expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50001884(8-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b...)
Affinity DataKi:  6.30nMAssay Description:Displacement of [3H]pirenzepine from human M1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Guinea pig)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM35254(CHEMBL715 | 2-methyl-4-(4-methylpiperazin-1-yl)-10...)
Affinity DataKi:  6.30nMAssay Description:Displacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(4) dopamine receptor(Human)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  6.30nMAssay Description:Displacement of [3H]spiperone from human dopamine D4.4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(3) dopamine receptor(Human)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50048803(5-[2-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-et...)
Affinity DataKi:  6.30nMAssay Description:Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM35254(CHEMBL715 | 2-methyl-4-(4-methylpiperazin-1-yl)-10...)
Affinity DataKi:  6.30nMAssay Description:Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50001888([3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-...)
Affinity DataKi:  6.30nMAssay Description:Displacement of [3H]ketanserin from human 5HT2A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50001884(8-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b...)
Affinity DataKi:  7.90nMAssay Description:Displacement of [3H]mesulergine from 5HT2C receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Guinea pig)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50001885(3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin...)
Affinity DataKi:  7.90nMAssay Description:Displacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50001884(8-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b...)
Affinity DataKi:  7.90nMAssay Description:Displacement of [3H]LSD from human 5HT6 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50176019(SLV-314 | (R)-8-(4-(3-(5-fluoro-1H-indol-3-yl)prop...)
Affinity DataKi:  7.90nMAssay Description:Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Guinea pig)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50001884(8-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b...)
Affinity DataKi:  7.90nMAssay Description:Displacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM35254(CHEMBL715 | 2-methyl-4-(4-methylpiperazin-1-yl)-10...)
Affinity DataKi:  7.90nMAssay Description:Displacement of [3H]LSD from human 5HT6 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50001885(3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin...)
Affinity DataKi:  7.90nMAssay Description:Displacement of [3H]RX 821002 from adrenergic alpha-2 receptor in rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50048803(5-[2-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-et...)
Affinity DataKi:  7.90nMAssay Description:Displacement of [3H]prazosin from adrenergic alpha1 receptor in rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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