Compile Data Set for Download or QSAR
Report error Found 12 Enz. Inhib. hit(s) with all data for entry = 50021149
TargetBeta-secretase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50212174(N-((5R,14R)-5-amino-5-methyl-4,16-dioxo-14-phenyl-...)
Affinity DataIC50: 2nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM16041(3-{5-[(1R)-1-amino-1-methyl-2-phenylethyl]-1,3,4-o...)
Affinity DataIC50: 9nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50221542(N-((R)-13-amino-13-methyl-14-oxo-15-oxa-2,20-diaza...)
Affinity DataIC50: 400nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50221538(N-((R)-5-amino-5,14-dimethyl-4-oxo-3-oxa-tricyclo[...)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50221537(N-((R)-5-amino-5,14-dimethyl-4-oxo-3-oxa-18-aza-tr...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50221545(N-((5R,14R)-5-amino-5-methyl-4-oxo-14-phenyl-16-tr...)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50221543(N-((R)-13-amino-2-cyclopropylmethyl-13-methyl-14-o...)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50221536(N-((R)-5-amino-5-methyl-4-oxo-14-phenyl-3-oxa-18-a...)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50221539(N-((R)-13-amino-2-benzyl-13-methyl-14-oxo-15-oxa-2...)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50221540(N-((R)-5-amino-5-methyl-4-oxo-3-oxa-18-aza-tricycl...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50221541(N-(3-(5-((R)-2-amino-1-(4-fluorophenyl)propan-2-yl...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50221544(N-((R)-13-amino-2-isopropyl-13-methyl-14-oxo-15-ox...)
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed