Compile Data Set for Download or QSAR
Report error Found 44 Enz. Inhib. hit(s) with all data for entry = 50021095
Target5-hydroxytryptamine receptor 1A(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50220920(1-(1H-indol-4-yloxy)-4-(cyclohexylamino)butan-2-ol...)
Affinity DataEC50:  394nMAssay Description:Antagonist activity at human 5HT1A expressed in mouse LM(tK-) cells assessed as 5-HT-stimulated [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50220924(4-(adamantan-1-ylamino)-1-(1H-indol-4-yloxy)-butan...)
Affinity DataEC50:  854nMAssay Description:Antagonist activity at human 5HT1A expressed in mouse LM(tK-) cells assessed as 5-HT-stimulated [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50019443(LB-46 | 1-(1H-Indol-4-yloxy)-3-isopropylamino-prop...)
Affinity DataKi:  0.400nMAssay Description:Binding affinity at human adrenergic beta2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-1 adrenergic receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50019443(LB-46 | 1-(1H-Indol-4-yloxy)-3-isopropylamino-prop...)
Affinity DataKi:  0.520nMAssay Description:Binding affinity at human adrenergic beta-1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50220910((S)-1-(1H-indol-4-yloxy)-3-(cyclohexylamino)propan...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-1 adrenergic receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50220910((S)-1-(1H-indol-4-yloxy)-3-(cyclohexylamino)propan...)
Affinity DataKi:  2.40nMAssay Description:Binding affinity at human adrenergic beta-1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50220914(1-(1H-indol-4-yloxy)-3-(cyclohexylamino)propan-2-o...)
Affinity DataKi:  3.60nMAssay Description:Displacement of [3H]DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50220910((S)-1-(1H-indol-4-yloxy)-3-(cyclohexylamino)propan...)
Affinity DataKi:  3.80nMAssay Description:Binding affinity at human adrenergic beta2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50220911((S)-1-(adamantan-1-ylamino)-3-(1H-indol-4-yloxy)-p...)
Affinity DataKi:  3.90nMAssay Description:Displacement of [3H]DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50220911((S)-1-(adamantan-1-ylamino)-3-(1H-indol-4-yloxy)-p...)
Affinity DataKi:  4.70nMAssay Description:Antagonist activity at human 5HT1A expressed in mouse LM(tK-) cells assessed as inhibition of 5-HT-stimulated [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50220911((S)-1-(adamantan-1-ylamino)-3-(1H-indol-4-yloxy)-p...)
Affinity DataKi:  6.60nMAssay Description:Binding affinity at human adrenergic beta2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50220910((S)-1-(1H-indol-4-yloxy)-3-(cyclohexylamino)propan...)
Affinity DataKi:  6.70nMAssay Description:Antagonist activity at human 5HT1A expressed in mouse LM(tK-) cells assessed as inhibition of 5-HT-stimulated [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50220912(1-(1H-indol-4-yloxy)-3-(cycloheptylamino)propan-2-...)
Affinity DataKi:  6.80nMAssay Description:Displacement of [3H]DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50220917(1-(adamantan-1-ylamino)-3-(1H-indol-4-yloxy)-propa...)
Affinity DataKi:  7.80nMAssay Description:Antagonist activity at human 5HT1A expressed in mouse LM(tK-) cells assessed as inhibition of 5-HT-stimulated [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-1 adrenergic receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50220911((S)-1-(adamantan-1-ylamino)-3-(1H-indol-4-yloxy)-p...)
Affinity DataKi:  7.90nMAssay Description:Binding affinity at human adrenergic beta-1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50220917(1-(adamantan-1-ylamino)-3-(1H-indol-4-yloxy)-propa...)
Affinity DataKi:  9.30nMAssay Description:Displacement of [3H]DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50220914(1-(1H-indol-4-yloxy)-3-(cyclohexylamino)propan-2-o...)
Affinity DataKi:  9.80nMAssay Description:Antagonist activity at human 5HT1A expressed in mouse LM(tK-) cells assessed as inhibition of 5-HT-stimulated [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50220912(1-(1H-indol-4-yloxy)-3-(cycloheptylamino)propan-2-...)
Affinity DataKi:  11nMAssay Description:Antagonist activity at human 5HT1A expressed in mouse LM(tK-) cells assessed as inhibition of 5-HT-stimulated [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50220918(1-(1H-indol-4-yloxy)-3-(cyclopentylamino)propan-2-...)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50220922((S)-1-(adamantan-2-ylamino)-3-(1H-indol-4-yloxy)-p...)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50220927((R)-1-(adamantan-1-ylamino)-3-(1H-indol-4-yloxy)-p...)
Affinity DataKi:  18nMAssay Description:Displacement of [3H]DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50019443(LB-46 | 1-(1H-Indol-4-yloxy)-3-isopropylamino-prop...)
Affinity DataKi:  22nMAssay Description:Displacement of [3H]DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50220922((S)-1-(adamantan-2-ylamino)-3-(1H-indol-4-yloxy)-p...)
Affinity DataKi:  24nMAssay Description:Antagonist activity at human 5HT1A expressed in mouse LM(tK-) cells assessed as inhibition of 5-HT-stimulated [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50220925((R)-1-(1H-indol-4-yloxy)-3-(cyclohexylamino)propan...)
Affinity DataKi:  26nMAssay Description:Displacement of [3H]DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50220915(1-(1H-indol-4-yloxy)-3-(pentan-3-ylamino)propan-2-...)
Affinity DataKi:  29nMAssay Description:Displacement of [3H]DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50220927((R)-1-(adamantan-1-ylamino)-3-(1H-indol-4-yloxy)-p...)
Affinity DataKi:  30nMAssay Description:Antagonist activity at human 5HT1A expressed in mouse LM(tK-) cells assessed as inhibition of 5-HT-stimulated [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50220930(adamantan-1-yl-[3-(1H-indol-4-yloxy)-2-methoxy-pro...)
Affinity DataKi:  32nMAssay Description:Displacement of [3H]DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50220918(1-(1H-indol-4-yloxy)-3-(cyclopentylamino)propan-2-...)
Affinity DataKi:  36nMAssay Description:Antagonist activity at human 5HT1A expressed in mouse LM(tK-) cells assessed as inhibition of 5-HT-stimulated [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50220928(N-(3-(1H-indol-4-yloxy)-2-methoxypropyl)cyclohexan...)
Affinity DataKi:  41nMAssay Description:Displacement of [3H]DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50220915(1-(1H-indol-4-yloxy)-3-(pentan-3-ylamino)propan-2-...)
Affinity DataKi:  50nMAssay Description:Antagonist activity at human 5HT1A expressed in mouse LM(tK-) cells assessed as inhibition of 5-HT-stimulated [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50220925((R)-1-(1H-indol-4-yloxy)-3-(cyclohexylamino)propan...)
Affinity DataKi:  51nMAssay Description:Antagonist activity at human 5HT1A expressed in mouse LM(tK-) cells assessed as inhibition of 5-HT-stimulated [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50220924(4-(adamantan-1-ylamino)-1-(1H-indol-4-yloxy)-butan...)
Affinity DataKi:  76nMAssay Description:Displacement of [3H]DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50220923(N-(3-(1H-indol-4-yloxy)propyl)cyclohexanamine | CH...)
Affinity DataKi:  78nMAssay Description:Displacement of [3H]DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50019443(LB-46 | 1-(1H-Indol-4-yloxy)-3-isopropylamino-prop...)
Affinity DataKi:  81nMAssay Description:Antagonist activity at human 5HT1A expressed in mouse LM(tK-) cells assessed as inhibition of 5-HT-stimulated [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50220921(N-(3-(1H-indol-4-yloxy)propyl)cyclopentanamine | C...)
Affinity DataKi:  94nMAssay Description:Displacement of [3H]DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50220920(1-(1H-indol-4-yloxy)-4-(cyclohexylamino)butan-2-ol...)
Affinity DataKi:  125nMAssay Description:Displacement of [3H]DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50220921(N-(3-(1H-indol-4-yloxy)propyl)cyclopentanamine | C...)
Affinity DataKi:  233nMAssay Description:Antagonist activity at human 5HT1A expressed in mouse LM(tK-) cells assessed as inhibition of 5-HT-stimulated [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50220932(1-(adamantan-1-ylamino)-4-(1H-indol-4-yloxy)-butan...)
Affinity DataKi:  551nMAssay Description:Displacement of [3H]DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50220931(1-(adamantan-1-ylamino)-3-(1H-indol-5-yloxy)-propa...)
Affinity DataKi:  833nMAssay Description:Displacement of [3H]DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50220926((S)-1-(adamantan-1-ylamino)-3-(1H-indol-4-yloxy)-2...)
Affinity DataKi:  868nMAssay Description:Displacement of [3H]DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50220919(4-(1H-indol-4-yloxy)-1-(cyclohexylamino)butan-2-ol...)
Affinity DataKi:  872nMAssay Description:Displacement of [3H]DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50220916((S)-1-(1H-indol-4-yloxy)-3-(cyclohexylamino)-2-met...)
Affinity DataKi:  1.45E+3nMAssay Description:Displacement of [3H]DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50220913(4-(1H-indol-4-yloxy)-1-(isopropylamino)butan-2-ol ...)
Affinity DataKi:  1.77E+3nMAssay Description:Displacement of [3H]DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50220929(1-(1H-indol-5-yloxy)-3-(cyclohexylamino)propan-2-o...)
Affinity DataKi: >3.00E+3nMAssay Description:Displacement of [3H]DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed