Compile Data Set for Download or QSAR
Report error Found 41 Enz. Inhib. hit(s) with all data for entry = 2238
LigandPNGBDBM18390((3R,5S)-6-[(3-{[(2,3-difluorophenyl)methyl]carbamo...)
Affinity DataIC50: 2nMpH: 7.2 T: 2°CAssay Description:Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM18372(CHEMBL1496 | Ros | (3R,5S,6E)-7-[4-(4-fluorophenyl...)
Affinity DataIC50: 2.10nMAssay Description:Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM18427((3R,5R)-7-[1-(4-fluorophenyl)-3-{[(3R)-3-phenylpip...)
Affinity DataIC50: 2.10nMAssay Description:Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM18425((3R,5R)-7-[1-(4-fluorophenyl)-3-{[(4-methylphenyl)...)
Affinity DataIC50: 2.5nMAssay Description:Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM18388((3R,5S)-6-{[3-(benzylcarbamoyl)-1-(4-fluorophenyl)...)
Affinity DataIC50: 3.80nMpH: 7.2 T: 2°CAssay Description:Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM18426((3R,5R)-7-[1-(4-fluorophenyl)-3-{[(3-fluorophenyl)...)
Affinity DataIC50: 4.10nMAssay Description:Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM18420((3R,5S)-6-{[1-(4-fluorophenyl)-3-{[(3R)-3-phenylpi...)
Affinity DataIC50: 4.80nMAssay Description:Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM18394((3R,5S)-6-{[1-(4-fluorophenyl)-3-{[(3-methylphenyl...)
Affinity DataIC50: 4.90nMpH: 7.2 T: 2°CAssay Description:Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM18389((3R,5S)-6-({3-[benzyl(methyl)carbamoyl]-1-(4-fluor...)
Affinity DataIC50: 5.20nMpH: 7.2 T: 2°CAssay Description:Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM18400((3R,5S)-6-[(3-{[(3-chlorophenyl)methyl]carbamoyl}-...)
Affinity DataIC50: 5.40nMpH: 7.2 T: 2°CAssay Description:Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM18409((3R,5S)-6-[(3-{[(3,4-difluorophenyl)methyl](methyl...)
Affinity DataIC50: 5.70nMAssay Description:Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM18424((3R,5R)-7-{3-[benzyl(methyl)carbamoyl]-1-(4-fluoro...)
Affinity DataIC50: 6.20nMAssay Description:Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM18417((3R,5S)-6-({3-[(cyclohexylmethyl)(methyl)carbamoyl...)
Affinity DataIC50: 6.20nMAssay Description:Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM18399((3R,5S)-6-[(3-{[(4-chlorophenyl)methyl]carbamoyl}-...)
Affinity DataIC50: 6.70nMpH: 7.2 T: 2°CAssay Description:Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM18405((3R,5S)-6-[(3-{[(3-chlorophenyl)methyl](methyl)car...)
Affinity DataIC50: 8.30nMpH: 7.2 T: 2°CAssay Description:Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM18410((3R,5S)-6-{[1-(4-fluorophenyl)-3-{[(2-fluorophenyl...)
Affinity DataIC50: 8.70nMAssay Description:Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM18401((3R,5S)-6-[(3-{[(2-chlorophenyl)methyl]carbamoyl}-...)
Affinity DataIC50: 9.5nMpH: 7.2 T: 2°CAssay Description:Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM18419((3R,5S)-6-{[1-(4-fluorophenyl)-4-(propan-2-yl)-3-(...)
Affinity DataIC50: 10nMAssay Description:Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM18396((3R,5S)-6-{[1-(4-fluorophenyl)-3-{[(4-methoxypheny...)
Affinity DataIC50: 12nMpH: 7.2 T: 2°CAssay Description:Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM18391((3R,5S)-6-[(3-{[(2,3-difluorophenyl)methyl](methyl...)
Affinity DataIC50: 14nMpH: 7.2 T: 2°CAssay Description:Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM18404((3R,5S)-6-{[1-(4-fluorophenyl)-3-{[(3-fluorophenyl...)
Affinity DataIC50: 14nMpH: 7.2 T: 2°CAssay Description:Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM18418((3R,5S)-6-{[1-(4-fluorophenyl)-3-[(2-phenylpyrroli...)
Affinity DataIC50: 14nMAssay Description:Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM18414((3R,5S)-6-({3-[benzyl(ethyl)carbamoyl]-1-(4-fluoro...)
Affinity DataIC50: 14nMAssay Description:Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM18413((3R,5S)-6-{[1-(4-fluorophenyl)-3-[(2-phenylethyl)c...)
Affinity DataIC50: 15nMAssay Description:Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM18393((3R,5S)-6-{[1-(4-fluorophenyl)-3-{[(4-methylphenyl...)
Affinity DataIC50: 15nMpH: 7.2 T: 2°CAssay Description:Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM18397((3R,5S)-6-{[1-(4-fluorophenyl)-3-{[(3-methoxypheny...)
Affinity DataIC50: 16nMpH: 7.2 T: 2°CAssay Description:Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM18402((3R,5S)-6-[(3-{[(3-ethoxyphenyl)methyl](methyl)car...)
Affinity DataIC50: 16nMpH: 7.2 T: 2°CAssay Description:Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM18415((3R,5S)-6-({3-[(cyclohexylmethyl)carbamoyl]-1-(4-f...)
Affinity DataIC50: 17nMAssay Description:Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM18395((3R,5S)-6-{[1-(4-fluorophenyl)-3-{[(2-methylphenyl...)
Affinity DataIC50: 17nMpH: 7.2 T: 2°CAssay Description:Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM18411((3R,5S)-6-{[1-(4-fluorophenyl)-3-{[(4-fluorophenyl...)
Affinity DataIC50: 18nMAssay Description:Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM18412((3R,5S)-6-{[1-(4-fluorophenyl)-3-{methyl[(1R)-1-ph...)
Affinity DataIC50: 21nMAssay Description:Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM18408((3R,5S)-6-{[1-(4-fluorophenyl)-3-{[(3-methoxypheny...)
Affinity DataIC50: 21nMpH: 7.2 T: 2°CAssay Description:Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM18398((3R,5S)-6-{[1-(4-fluorophenyl)-3-{[(2-methoxypheny...)
Affinity DataIC50: 22nMpH: 7.2 T: 2°CAssay Description:Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM18422((3R,5S)-6-{[1-(4-fluorophenyl)-4-(propan-2-yl)-3-[...)
Affinity DataIC50: 25nMAssay Description:Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM18407((3R,5S)-6-{[1-(4-fluorophenyl)-3-[methyl({[3-(trif...)
Affinity DataIC50: 31nMpH: 7.2 T: 2°CAssay Description:Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM18423((3R,5S)-6-{[1-(4-fluorophenyl)-3-({[3-(methoxymeth...)
Affinity DataIC50: 31nMAssay Description:Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM18406((3R,5S)-6-{[1-(4-fluorophenyl)-3-{methyl[(3-methyl...)
Affinity DataIC50: 37nMpH: 7.2 T: 2°CAssay Description:Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM18392((3R,5S)-6-{[1-(4-fluorophenyl)-3-{methyl[(4-methyl...)
Affinity DataIC50: 37nMpH: 7.2 T: 2°CAssay Description:Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM18403((3R,5S)-6-[(3-{[(3,5-dimethoxyphenyl)methyl](methy...)
Affinity DataIC50: 43nMpH: 7.2 T: 2°CAssay Description:Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM18421((3R,5S)-6-{[1-(4-fluorophenyl)-3-(piperidin-1-ylca...)
Affinity DataIC50: 47nMAssay Description:Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM18416((3R,5S)-6-{[3-(butylcarbamoyl)-1-(4-fluorophenyl)-...)
Affinity DataIC50: 76nMAssay Description:Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed