Compile Data Set for Download or QSAR
Report error Found 37 Enz. Inhib. hit(s) with all data for entry = 50020784
LigandPNGBDBM50217493(N-((3R,6S)-1-(cyclopropylmethyl)-2-oxo-6-phenylaze...)
Affinity DataIC50: 4nMAssay Description:Antagonist activity at human CGRP receptor in E10 cells assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50217485(N-((3R,6S)-1-(cyclopropylmethyl)-2-oxo-6-phenylaze...)
Affinity DataIC50: 32nMAssay Description:Antagonist activity at human CGRP receptor in E10 cells assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50217495(N-((3R,6S)-1-(cyclopropylmethyl)-2-oxo-6-phenylaze...)
Affinity DataIC50: 36nMAssay Description:Antagonist activity at human CGRP receptor in E10 cells assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50217488(N-((3R,6S)-1-(cyclopropylmethyl)-2-oxo-6-phenylaze...)
Affinity DataIC50: 45nMAssay Description:Antagonist activity at human CGRP receptor in E10 cells assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50217486((cis racemic)-N-(1-(cyclopropylmethyl)-2-oxo-6-phe...)
Affinity DataIC50: 54nMAssay Description:Antagonist activity at human CGRP receptor in E10 cells assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50217486((cis racemic)-N-(1-(cyclopropylmethyl)-2-oxo-6-phe...)
Affinity DataIC50: 54nMAssay Description:Antagonist activity at human CGRP receptor in E10 cells assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50217498((R,Z)-N-(1-isopropyl-2-oxo-5-phenyl-2,3-dihydro-1H...)
Affinity DataIC50: 65nMAssay Description:Antagonist activity at human CGRP receptor in E10 cells assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50217483((trans racemic)-N-(1-(cyclopropylmethyl)-2-oxo-5-p...)
Affinity DataIC50: 133nMAssay Description:Antagonist activity at human CGRP receptor in E10 cells assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50217483((trans racemic)-N-(1-(cyclopropylmethyl)-2-oxo-5-p...)
Affinity DataIC50: 141nMAssay Description:Antagonist activity at human CGRP receptor in E10 cells assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50217490(N-((3R,7R)-1-(cyclopropylmethyl)-2-oxo-7-phenylaze...)
Affinity DataIC50: 408nMAssay Description:Antagonist activity at human CGRP receptor in E10 cells assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50217482(tert-butyl 2-((3S,7S)-2-oxo-3-(4-(2-oxo-1,2-dihydr...)
Affinity DataIC50: 471nMAssay Description:Antagonist activity at human CGRP receptor in E10 cells assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50217491((trans racemic)-N-((3R)-1-(cyclopropylmethyl)-2-ox...)
Affinity DataIC50: 488nMAssay Description:Antagonist activity at human CGRP receptor in E10 cells assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50217491((trans racemic)-N-((3R)-1-(cyclopropylmethyl)-2-ox...)
Affinity DataIC50: 488nMAssay Description:Antagonist activity at human CGRP receptor in E10 cells assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50217482(tert-butyl 2-((3S,7S)-2-oxo-3-(4-(2-oxo-1,2-dihydr...)
Affinity DataIC50: 2.12E+3nMAssay Description:Antagonist activity at human CGRP receptor in E10 cells assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50217489((R)-N-(1-(cyclopropylmethyl)-2-oxoazepan-3-yl)-4-(...)
Affinity DataIC50: 2.40E+3nMAssay Description:Antagonist activity at human CGRP receptor in E10 cells assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50217492(N-(1-isopropyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b...)
Affinity DataIC50: 3.10E+3nMAssay Description:Antagonist activity at human CGRP receptor in E10 cells assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50217496(N-((3S,6R)-1-(cyclopropylmethyl)-2-oxo-6-phenylaze...)
Affinity DataIC50: 6.63E+3nMAssay Description:Antagonist activity at human CGRP receptor in E10 cells assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50217493(N-((3R,6S)-1-(cyclopropylmethyl)-2-oxo-6-phenylaze...)
Affinity DataKi:  2nMAssay Description:Displacement of [125I]CGRP from human CL receptor in RAMP1 membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50217495(N-((3R,6S)-1-(cyclopropylmethyl)-2-oxo-6-phenylaze...)
Affinity DataKi:  25nMAssay Description:Displacement of [125I]CGRP from human CL receptor in RAMP1 membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50217488(N-((3R,6S)-1-(cyclopropylmethyl)-2-oxo-6-phenylaze...)
Affinity DataKi:  29nMAssay Description:Displacement of [125I]CGRP from human CL receptor in RAMP1 membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50217485(N-((3R,6S)-1-(cyclopropylmethyl)-2-oxo-6-phenylaze...)
Affinity DataKi:  29nMAssay Description:Displacement of [125I]CGRP from human CL receptor in RAMP1 membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50217486((cis racemic)-N-(1-(cyclopropylmethyl)-2-oxo-6-phe...)
Affinity DataKi:  31nMAssay Description:Displacement of [125I]CGRP from human CL receptor in RAMP1 membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50217486((cis racemic)-N-(1-(cyclopropylmethyl)-2-oxo-6-phe...)
Affinity DataKi:  31nMAssay Description:Displacement of [125I]CGRP from human CL receptor in RAMP1 membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50217483((trans racemic)-N-(1-(cyclopropylmethyl)-2-oxo-5-p...)
Affinity DataKi:  35nMAssay Description:Displacement of [125I]CGRP from human CL receptor in RAMP1 membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50217483((trans racemic)-N-(1-(cyclopropylmethyl)-2-oxo-5-p...)
Affinity DataKi:  35nMAssay Description:Displacement of [125I]CGRP from human CL receptor in RAMP1 membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50217498((R,Z)-N-(1-isopropyl-2-oxo-5-phenyl-2,3-dihydro-1H...)
Affinity DataKi:  55nMAssay Description:Displacement of [125I]CGRP from human CL receptor in RAMP1 membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50217491((trans racemic)-N-((3R)-1-(cyclopropylmethyl)-2-ox...)
Affinity DataKi:  266nMAssay Description:Displacement of [125I]CGRP from human CL receptor in RAMP1 membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50217491((trans racemic)-N-((3R)-1-(cyclopropylmethyl)-2-ox...)
Affinity DataKi:  266nMAssay Description:Displacement of [125I]CGRP from human CL receptor in RAMP1 membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50217490(N-((3R,7R)-1-(cyclopropylmethyl)-2-oxo-7-phenylaze...)
Affinity DataKi:  689nMAssay Description:Displacement of [125I]CGRP from human CL receptor in RAMP1 membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50217497(tert-butyl 2-((3R,7R)-2-oxo-3-(4-(2-oxo-1,2-dihydr...)
Affinity DataKi:  934nMAssay Description:Displacement of [125I]CGRP from human CL receptor in RAMP1 membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50217484((R)-N-(1-benzyl-2-oxoazepan-3-yl)-4-(2-oxo-1,2-dih...)
Affinity DataKi:  1.80E+3nMAssay Description:Displacement of [125I]CGRP from human CL receptor in RAMP1 membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50217499((trans racemic)-tert-butyl 2-(2-oxo-3-(4-(2-oxo-1,...)
Affinity DataKi:  1.99E+3nMAssay Description:Displacement of [125I]CGRP from human CL receptor in RAMP1 membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50217492(N-(1-isopropyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b...)
Affinity DataKi:  3.70E+3nMAssay Description:Displacement of [125I]CGRP from human CL receptor in RAMP1 membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50217496(N-((3S,6R)-1-(cyclopropylmethyl)-2-oxo-6-phenylaze...)
Affinity DataKi:  5.83E+3nMAssay Description:Displacement of [125I]CGRP from human CL receptor in RAMP1 membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50217489((R)-N-(1-(cyclopropylmethyl)-2-oxoazepan-3-yl)-4-(...)
Affinity DataKi:  7.80E+3nMAssay Description:Displacement of [125I]CGRP from human CL receptor in RAMP1 membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50217482(tert-butyl 2-((3S,7S)-2-oxo-3-(4-(2-oxo-1,2-dihydr...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [125I]CGRP from human CL receptor in RAMP1 membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50217494((S)-N-(1-benzyl-2-oxoazepan-3-yl)-4-(2-oxo-1,2-dih...)
Affinity DataKi:  1.11E+4nMAssay Description:Displacement of [125I]CGRP from human CL receptor in RAMP1 membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed