Compile Data Set for Download or QSAR
Report error Found 26 Enz. Inhib. hit(s) with all data for entry = 2316
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM19284(N-{2-[3-(dimethylsulfamoyl)phenyl]propan-2-yl}-2-f...)
Affinity DataIC50: 7.90nM EC50:  380nMpH: 8.0 T: 2°CAssay Description:Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2007
Entry Details Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM19283(N-{2-[4-(dimethylsulfamoyl)phenyl]propan-2-yl}-2-f...)
Affinity DataIC50: 10nM EC50:  660nMpH: 8.0 T: 2°CAssay Description:Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2007
Entry Details Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM19292(2-fluoro-N-{2-[5-methyl-6-(morpholin-4-yl)pyridin-...)
Affinity DataIC50: 11nM EC50:  870nMpH: 8.0 T: 2°CAssay Description:Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2007
Entry Details Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM19279(2-fluoro-9-oxo-N-[2-(pyridin-3-yl)propan-2-yl]-9,1...)
Affinity DataIC50: 11nM EC50:  420nMpH: 8.0 T: 2°CAssay Description:Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2007
Entry Details Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM19277(2-fluoro-9-oxo-N-(2-phenylpropan-2-yl)-9,10-dihydr...)
Affinity DataIC50: 11nM EC50:  830nMpH: 8.0 T: 2°CAssay Description:Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2007
Entry Details Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM19282(2-fluoro-N-[2-(3-methanesulfonylphenyl)propan-2-yl...)
Affinity DataIC50: 12nM EC50:  580nMpH: 8.0 T: 2°CAssay Description:Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2007
Entry Details Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM19281(2-fluoro-N-[2-(4-methanesulfonylphenyl)propan-2-yl...)
Affinity DataIC50: 12nM EC50:  480nMpH: 8.0 T: 2°CAssay Description:Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2007
Entry Details Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM19288(N-{2-[2-(dimethylamino)pyridin-4-yl]propan-2-yl}-2...)
Affinity DataIC50: 14nM EC50:  640nMpH: 8.0 T: 2°CAssay Description:Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2007
Entry Details Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM19264(CHEMBL866 | Myfortic | (4E)-6-(4-hydroxy-6-methoxy...)
Affinity DataIC50: 16nM EC50:  540nMpH: 8.0 T: 2°CAssay Description:Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM19289(Acridone-Based Inhibitor, 4m | N-{2-[6-(4-ethylpip...)
Affinity DataIC50: 17nM EC50:  770nMpH: 8.0 T: 2°CAssay Description:Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2007
Entry Details Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM19285(2-fluoro-9-oxo-N-(2-{2H,3H,4H-pyrido[3,2-b][1,4]ox...)
Affinity DataIC50: 17nM EC50:  920nMpH: 8.0 T: 2°CAssay Description:Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2007
Entry Details Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM19270(9-oxo-N-(2-phenylpropan-2-yl)-9,10-dihydroacridine...)
Affinity DataIC50: 19nM EC50:  2.10E+3nMpH: 8.0 T: 2°CAssay Description:Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2007
Entry Details Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM19280(N-(2-{4-[2-(dimethylamino)ethoxy]phenyl}propan-2-y...)
Affinity DataIC50: 20nM EC50:  560nMpH: 8.0 T: 2°CAssay Description:Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2007
Entry Details Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM19291(2-fluoro-N-{2-[5-methoxy-6-(morpholin-4-yl)pyridin...)
Affinity DataIC50: 20nM EC50:  810nMpH: 8.0 T: 2°CAssay Description:Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2007
Entry Details Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM19290(2-fluoro-N-{2-[6-(morpholin-4-yl)pyridin-3-yl]prop...)
Affinity DataIC50: 20nM EC50:  660nMpH: 8.0 T: 2°CAssay Description:Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2007
Entry Details Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM19287(N-{2-[6-(dimethylamino)pyridin-3-yl]propan-2-yl}-2...)
Affinity DataIC50: 22nM EC50:  850nMpH: 8.0 T: 2°CAssay Description:Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2007
Entry Details Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM19286(2-fluoro-N-[2-(6-methylpyridin-3-yl)propan-2-yl]-9...)
Affinity DataIC50: 23nM EC50:  750nMpH: 8.0 T: 2°CAssay Description:Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2007
Entry Details Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM19278(2-fluoro-9-oxo-N-[2-(pyridin-2-yl)propan-2-yl]-9,1...)
Affinity DataIC50: 29nM EC50:  1.00E+3nMpH: 8.0 T: 2°CAssay Description:Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2007
Entry Details Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM19275(9-oxo-N-[2-(pyridin-3-yl)propan-2-yl]-9,10-dihydro...)
Affinity DataIC50: 42nM EC50:  2.20E+3nMpH: 8.0 T: 2°CAssay Description:Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2007
Entry Details Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM19276(9-oxo-N-[2-(pyridin-4-yl)propan-2-yl]-9,10-dihydro...)
Affinity DataIC50: 53nM EC50:  2.30E+3nMpH: 8.0 T: 2°CAssay Description:Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2007
Entry Details Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM19274(9-oxo-N-[2-(pyridin-2-yl)propan-2-yl]-9,10-dihydro...)
Affinity DataIC50: 53nM EC50:  2.20E+3nMpH: 8.0 T: 2°CAssay Description:Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2007
Entry Details Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM19269(N-tert-butyl-9-oxo-9,10-dihydroacridine-3-carboxam...)
Affinity DataIC50: 59nM EC50:  3.30E+3nMpH: 8.0 T: 2°CAssay Description:Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2007
Entry Details Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM19268(ethyl 9-oxo-9,10-dihydroacridine-3-carboxylate | A...)
Affinity DataIC50: 59nM EC50: >1.00E+4nMpH: 8.0 T: 2°CAssay Description:Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2007
Entry Details Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM19272(9-oxo-N-[(1R)-1-phenylethyl]-9,10-dihydroacridine-...)
Affinity DataIC50: 95nMpH: 8.0 T: 2°CAssay Description:Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2007
Entry Details Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM19273(9-oxo-N-[(1S)-1-phenylethyl]-9,10-dihydroacridine-...)
Affinity DataIC50: 431nMpH: 8.0 T: 2°CAssay Description:Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2007
Entry Details Article
PubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Human)
Bristol-Myers Squibb

LigandPNGBDBM19271(N-benzyl-9-oxo-9,10-dihydroacridine-3-carboxamide ...)
Affinity DataIC50: 2.20E+3nMpH: 8.0 T: 2°CAssay Description:Inhibition assays were performed using recombinant human IMPDH type 2 and varying concentrations of inhibitor. The production of NADH was monitored b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2007
Entry Details Article
PubMed