Compile Data Set for Download or QSAR
Report error Found 13 Enz. Inhib. hit(s) with all data for entry = 50020664
TargetBeta-secretase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50216173(N-[(1S,2R)-2-amino-1-benzyl-3-fluoropropyl]-2-[(is...)
Affinity DataIC50: 2nMAssay Description:Inhibition of BACE1 by ECL assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50216175(N-[(1S,2R)-2-amino-1-benzyl-3-methoxypropyl]-2-(me...)
Affinity DataIC50: 12nMAssay Description:Inhibition of BACE1 by ECL assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50216179(N-[(1S)-1-benzyl-2-hydroxyethyl]-2-[(isopropylsulf...)
Affinity DataIC50: 14nMAssay Description:Inhibition of BACE1 by ECL assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50216174(N-[(1S,2R)-2-amino-1-benzyl-3-fluoropropyl]-2-[(is...)
Affinity DataIC50: 18nMAssay Description:Inhibition of BACE1 by ECL assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50216176(N-[(1S)-2-amino-1-benzylethyl]-2-{trans-[(2-methyl...)
Affinity DataIC50: 34nMAssay Description:Inhibition of BACE1 by ECL assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50216173(N-[(1S,2R)-2-amino-1-benzyl-3-fluoropropyl]-2-[(is...)
Affinity DataIC50: 49nMAssay Description:Inhibition of BACE1 assessed as effect on soluble APPbeta N-terminal fragment secretion in HEK293T cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50216175(N-[(1S,2R)-2-amino-1-benzyl-3-methoxypropyl]-2-(me...)
Affinity DataIC50: 173nMAssay Description:Inhibition of BACE1 assessed as effect on soluble APPbeta N-terminal fragment secretion in HEK293T cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50216176(N-[(1S)-2-amino-1-benzylethyl]-2-{trans-[(2-methyl...)
Affinity DataIC50: 280nMAssay Description:Inhibition of BACE1 assessed as effect on soluble APPbeta N-terminal fragment secretion in HEK293T cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50216178(N-[(1S)-1-benzyl-2-hydroxyethyl]-2-[(cyclopropylme...)
Affinity DataIC50: 350nMAssay Description:Inhibition of BACE1 by ECL assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50216174(N-[(1S,2R)-2-amino-1-benzyl-3-fluoropropyl]-2-[(is...)
Affinity DataIC50: 910nMAssay Description:Inhibition of BACE1 assessed as effect on soluble APPbeta N-terminal fragment secretion in HEK293T cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50216177(N-[(1S)-1-benzyl-2-hydroxyethyl]-2-[(cyclopropylme...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of BACE1 by ECL assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50216178(N-[(1S)-1-benzyl-2-hydroxyethyl]-2-[(cyclopropylme...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of BACE1 assessed as effect on soluble APPbeta N-terminal fragment secretion in HEK293T cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50216179(N-[(1S)-1-benzyl-2-hydroxyethyl]-2-[(isopropylsulf...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of BACE1 assessed as effect on soluble APPbeta N-terminal fragment secretion in HEK293T cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed