Compile Data Set for Download or QSAR
Report error Found 69 Enz. Inhib. hit(s) with all data for entry = 50020435
TargetC-X-C chemokine receptor type 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50213750(3-(2-bromo-phenylamino)-7-nitro-1,1-dioxo-1,4-dihy...)
Affinity DataIC50: 26nMAssay Description:Antagonist activity at CXCR2 receptor expressed in CHOK1 cells assessed as human IL8-induced calcium mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50213736(7-chloro-1,1-dioxo-3-(2-phenoxy-phenylamino)-1,4-d...)
Affinity DataIC50: 54nMAssay Description:Antagonist activity at CXCR2 receptor expressed in CHOK1 cells assessed as human IL8-induced calcium mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50213737(7-nitro-1,1-dioxo-3-(2-phenoxy-phenylamino)-1,4-di...)
Affinity DataIC50: 54nMAssay Description:Displacement of human recombinant [125I]IL8 from CXCR2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50213741(3-(2-bromo-phenylamino)-7-chloro-1,1-dioxo-1,4-dih...)
Affinity DataIC50: 64nMAssay Description:Antagonist activity at CXCR2 receptor expressed in CHOK1 cells assessed as human IL8-induced calcium mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50213746(7-chloro-3-(2-chloro-3-fluoro-phenylamino)-1,1-dio...)
Affinity DataIC50: 64nMAssay Description:Antagonist activity at CXCR2 receptor expressed in CHOK1 cells assessed as human IL8-induced calcium mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50213758(7-bromo-3-(2-bromo-phenylamino)-1,1-dioxo-1,4-dihy...)
Affinity DataIC50: 70nMAssay Description:Antagonist activity at CXCR2 receptor expressed in CHOK1 cells assessed as human IL8-induced calcium mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50213744(3-(2-chloro-phenylamino)-7-nitro-1,1-dioxo-1,4-dih...)
Affinity DataIC50: 81nMAssay Description:Displacement of human recombinant [125I]IL8 from CXCR2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50213747(7-chloro-3-(2-chloro-phenylamino)-1,1-dioxo-1,4-di...)
Affinity DataIC50: 92nMAssay Description:Antagonist activity at CXCR2 receptor expressed in CHOK1 cells assessed as human IL8-induced calcium mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50213755(3-(2-bromo-4-fluoro-phenylamino)-7-chloro-1,1-diox...)
Affinity DataIC50: 120nMAssay Description:Antagonist activity at CXCR2 receptor expressed in CHOK1 cells assessed as human IL8-induced calcium mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50213763(3-(biphenyl-2-ylamino)-7-chloro-1,1-dioxo-1,4-dihy...)
Affinity DataIC50: 230nMAssay Description:Antagonist activity at CXCR2 receptor expressed in CHOK1 cells assessed as human IL8-induced calcium mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50213762(7-chloro-3-(2-methoxy-phenylamino)-1,1-dioxo-1,4-d...)
Affinity DataIC50: 250nMAssay Description:Antagonist activity at CXCR2 receptor expressed in CHOK1 cells assessed as human IL8-induced calcium mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50213756(3-(2-bromo-phenylamino)-7-methyl-1,1-dioxo-1,4-dih...)
Affinity DataIC50: 280nMAssay Description:Antagonist activity at CXCR2 receptor expressed in CHOK1 cells assessed as human IL8-induced calcium mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50213736(7-chloro-1,1-dioxo-3-(2-phenoxy-phenylamino)-1,4-d...)
Affinity DataIC50: 320nMAssay Description:Antagonist activity at CXCR2 receptor expressed in CHOK1 cells assessed as human IL8-induced calcium mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50213761(3-(2-bromo-phenylamino)-7-fluoro-1,1-dioxo-1,4-dih...)
Affinity DataIC50: 360nMAssay Description:Antagonist activity at CXCR2 receptor expressed in CHOK1 cells assessed as human IL8-induced calcium mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50213759(7-chloro-1,1-dioxo-3-o-tolylamino-1,4-dihydro-1lam...)
Affinity DataIC50: 390nMAssay Description:Antagonist activity at CXCR2 receptor expressed in CHOK1 cells assessed as human IL8-induced calcium mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50213741(3-(2-bromo-phenylamino)-7-chloro-1,1-dioxo-1,4-dih...)
Affinity DataIC50: 400nMAssay Description:Antagonist activity at CXCR2 receptor expressed in CHOK1 cells assessed as human IL8-induced calcium mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50213746(7-chloro-3-(2-chloro-3-fluoro-phenylamino)-1,1-dio...)
Affinity DataIC50: 460nMAssay Description:Antagonist activity at CXCR2 receptor expressed in CHOK1 cells assessed as human IL8-induced calcium mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50213743(3-(2-bromo-phenylamino)-8-chloro-1,1-dioxo-1,4-dih...)
Affinity DataIC50: 480nMAssay Description:Antagonist activity at CXCR2 receptor expressed in CHOK1 cells assessed as human IL8-induced calcium mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50213737(7-nitro-1,1-dioxo-3-(2-phenoxy-phenylamino)-1,4-di...)
Affinity DataIC50: 490nMAssay Description:Antagonist activity at CXCR2 receptor expressed in CHOK1 cells assessed as human IL8-induced calcium mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50213747(7-chloro-3-(2-chloro-phenylamino)-1,1-dioxo-1,4-di...)
Affinity DataIC50: 520nMAssay Description:Antagonist activity at CXCR2 receptor expressed in CHOK1 cells assessed as human IL8-induced calcium mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50213750(3-(2-bromo-phenylamino)-7-nitro-1,1-dioxo-1,4-dihy...)
Affinity DataIC50: 600nMAssay Description:Antagonist activity at CXCR2 receptor expressed in CHOK1 cells assessed as human IL8-induced calcium mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50213744(3-(2-chloro-phenylamino)-7-nitro-1,1-dioxo-1,4-dih...)
Affinity DataIC50: 600nMAssay Description:Inhibition of human CYP2C9More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50213753(7-chloro-3-(2-fluoro-phenylamino)-1,1-dioxo-1,4-di...)
Affinity DataIC50: 740nMAssay Description:Antagonist activity at CXCR2 receptor expressed in CHOK1 cells assessed as human IL8-induced calcium mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50213745(7-chloro-1,1-dioxo-3-(2-trifluoromethyl-phenylamin...)
Affinity DataIC50: 830nMAssay Description:Antagonist activity at CXCR2 receptor expressed in CHOK1 cells assessed as human IL8-induced calcium mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50213764(7-chloro-1,1-dioxo-3-(2-trifluoromethoxy-phenylami...)
Affinity DataIC50: 930nMAssay Description:Antagonist activity at CXCR2 receptor expressed in CHOK1 cells assessed as human IL8-induced calcium mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50213737(7-nitro-1,1-dioxo-3-(2-phenoxy-phenylamino)-1,4-di...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of adrenergic alpha-1A receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50213744(3-(2-chloro-phenylamino)-7-nitro-1,1-dioxo-1,4-dih...)
Affinity DataIC50: 1.10E+3nMAssay Description:Antagonist activity at CXCR2 receptor expressed in CHOK1 cells assessed as human IL8-induced calcium mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50213757(3-(2-bromo-6-fluoro-phenylamino)-7-chloro-1,1-diox...)
Affinity DataIC50: 1.60E+3nMAssay Description:Antagonist activity at CXCR2 receptor expressed in CHOK1 cells assessed as human IL8-induced calcium mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50213765(7-chloro-1,1-dioxo-3-phenylamino-1,4-dihydro-1lamb...)
Affinity DataIC50: 2.40E+3nMAssay Description:Antagonist activity at CXCR2 receptor expressed in CHOK1 cells assessed as human IL8-induced calcium mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50213751(3-(2-bromo-phenylamino)-8-fluoro-1,1-dioxo-1,4-dih...)
Affinity DataIC50: 3.00E+3nMAssay Description:Antagonist activity at CXCR2 receptor expressed in CHOK1 cells assessed as human IL8-induced calcium mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50213737(7-nitro-1,1-dioxo-3-(2-phenoxy-phenylamino)-1,4-di...)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50213737(7-nitro-1,1-dioxo-3-(2-phenoxy-phenylamino)-1,4-di...)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of 5HT1D receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50213737(7-nitro-1,1-dioxo-3-(2-phenoxy-phenylamino)-1,4-di...)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of dopamine D2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H3 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50213737(7-nitro-1,1-dioxo-3-(2-phenoxy-phenylamino)-1,4-di...)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50213737(7-nitro-1,1-dioxo-3-(2-phenoxy-phenylamino)-1,4-di...)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of 5HT1B receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(3) dopamine receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50213737(7-nitro-1,1-dioxo-3-(2-phenoxy-phenylamino)-1,4-di...)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of dopamine D3 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-X-C chemokine receptor type 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50213750(3-(2-bromo-phenylamino)-7-nitro-1,1-dioxo-1,4-dihy...)
Affinity DataIC50: 3.20E+3nMAssay Description:Displacement of human recombinant [125I]IL8 from CXCR1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50213754(3-(2-bromo-5-fluoro-phenylamino)-7-chloro-1,1-diox...)
Affinity DataIC50: 3.90E+3nMAssay Description:Antagonist activity at CXCR2 receptor expressed in CHOK1 cells assessed as human IL8-induced calcium mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50213740(1-[2-(7-chloro-5-hydroxy-1,1-dioxo-1,4-dihydro-1la...)
Affinity DataIC50: 4.50E+3nMAssay Description:Antagonist activity at CXCR2 receptor expressed in CHOK1 cells assessed as human IL8-induced calcium mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50213760(3-(4-bromo-phenylamino)-7-chloro-1,1-dioxo-1,4-dih...)
Affinity DataIC50: 5.10E+3nMAssay Description:Antagonist activity at CXCR2 receptor expressed in CHOK1 cells assessed as human IL8-induced calcium mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50213738(3-(2-chloro-phenylamino)-1,1-dioxo-1,4-dihydro-1la...)
Affinity DataIC50: 5.20E+3nMAssay Description:Antagonist activity at CXCR2 receptor expressed in CHOK1 cells assessed as human IL8-induced calcium mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50213749(3-(3-bromo-phenylamino)-7-chloro-1,1-dioxo-1,4-dih...)
Affinity DataIC50: 6.10E+3nMAssay Description:Antagonist activity at CXCR2 receptor expressed in CHOK1 cells assessed as human IL8-induced calcium mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-X-C chemokine receptor type 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50213737(7-nitro-1,1-dioxo-3-(2-phenoxy-phenylamino)-1,4-di...)
Affinity DataIC50: 7.60E+3nMAssay Description:Displacement of human recombinant [125I]IL8 from CXCR1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlasminogen activator inhibitor 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50213737(7-nitro-1,1-dioxo-3-(2-phenoxy-phenylamino)-1,4-di...)
Affinity DataIC50: 7.90E+3nMAssay Description:Inhibition of PAI1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50213737(7-nitro-1,1-dioxo-3-(2-phenoxy-phenylamino)-1,4-di...)
Affinity DataIC50: 7.90E+3nMAssay Description:Inhibition of 5HT6 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50213767(3-benzylamino-7-chloro-1,1-dioxo-1,4-dihydro-1lamb...)
Affinity DataIC50: 8.00E+3nMAssay Description:Antagonist activity at CXCR2 receptor expressed in CHOK1 cells assessed as human IL8-induced calcium mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50213737(7-nitro-1,1-dioxo-3-(2-phenoxy-phenylamino)-1,4-di...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50213737(7-nitro-1,1-dioxo-3-(2-phenoxy-phenylamino)-1,4-di...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of 5HT2C receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-X-C chemokine receptor type 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50213744(3-(2-chloro-phenylamino)-7-nitro-1,1-dioxo-1,4-dih...)
Affinity DataIC50: 1.20E+4nMAssay Description:Displacement of human recombinant [125I]IL8 from CXCR1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-X-C chemokine receptor type 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50213746(7-chloro-3-(2-chloro-3-fluoro-phenylamino)-1,1-dio...)
Affinity DataIC50: 1.30E+4nMAssay Description:Displacement of human recombinant [125I]IL8 from CXCR1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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