Compile Data Set for Download or QSAR
Report error Found 31 Enz. Inhib. hit(s) with all data for entry = 50037946
TargetKappa-type opioid receptor(Guinea pig)
Institut F£R Pharmazeutische Und Medizinische Chemie

Curated by ChEMBL
LigandPNGBDBM50000296(CHEMBL441765 | CHEMBL482811 | U-50488H | US1149237...)
Affinity DataKi:  0.490nMAssay Description:Displacement of [3H]U-69593 from kappa opioid receptor in guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
Institut F£R Pharmazeutische Und Medizinische Chemie

Curated by ChEMBL
LigandPNGBDBM50000788([17-(2,3-3H-2-propenyl)]-4, 5a -epoxy-3,14-dihydro...)
Affinity DataKi:  0.680nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Institut F£R Pharmazeutische Und Medizinische Chemie

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  2.20nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetKappa-type opioid receptor(Guinea pig)
Institut F£R Pharmazeutische Und Medizinische Chemie

Curated by ChEMBL
LigandPNGBDBM50000788([17-(2,3-3H-2-propenyl)]-4, 5a -epoxy-3,14-dihydro...)
Affinity DataKi:  3.17nMAssay Description:Displacement of [3H]U-69593 from kappa opioid receptor in guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Institut F£R Pharmazeutische Und Medizinische Chemie

Curated by ChEMBL
LigandPNGBDBM50035131((1S,9S,13S)-1,13-dimethyl-10-(3-methylbut-2-enyl)-...)
Affinity DataKi:  3.58nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Institut F£R Pharmazeutische Und Medizinische Chemie

Curated by ChEMBL
LigandPNGBDBM50210193(6-benzyl-8-butyl-2-methoxy-6,8-diaza-bicyclo[3.2.2...)
Affinity DataKi:  13.2nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Institut F£R Pharmazeutische Und Medizinische Chemie

Curated by ChEMBL
LigandPNGBDBM50210185((1R,2R,5S )-6-benzyl-2-benzyloxy-8-methyl-6,8-diaz...)
Affinity DataKi:  16.2nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Institut F£R Pharmazeutische Und Medizinische Chemie

Curated by ChEMBL
LigandPNGBDBM50210187(6-benzyl-8-butyl-6,8-diaza-bicyclo[3.2.2]nonan-2-o...)
Affinity DataKi:  23.4nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Institut F£R Pharmazeutische Und Medizinische Chemie

Curated by ChEMBL
LigandPNGBDBM50210184((1R,2R,5S )-6-benzyl-8-(2-phenylethyl)-6,8-diazabi...)
Affinity DataKi:  29.5nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Institut F£R Pharmazeutische Und Medizinische Chemie

Curated by ChEMBL
LigandPNGBDBM50210183((1R,2S,5S )-6-Benzyl-8-(2-phenylethyl)-6,8-diazabi...)
Affinity DataKi:  33.3nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Institut F£R Pharmazeutische Und Medizinische Chemie

Curated by ChEMBL
LigandPNGBDBM50210181(6-benzyl-2-(benzyloxy)-8-butyl-6,8-diaza-bicyclo[3...)
Affinity DataKi:  39.5nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Institut F£R Pharmazeutische Und Medizinische Chemie

Curated by ChEMBL
LigandPNGBDBM50210182(6-benzyl-2-methoxy-8-phenethyl-6,8-diaza-bicyclo[3...)
Affinity DataKi:  76nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
Institut F£R Pharmazeutische Und Medizinische Chemie

Curated by ChEMBL
LigandPNGBDBM50210193(6-benzyl-8-butyl-2-methoxy-6,8-diaza-bicyclo[3.2.2...)
Affinity DataKi:  157nMAssay Description:Displacement of [3H]U-69593 from kappa opioid receptor in guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Institut F£R Pharmazeutische Und Medizinische Chemie

Curated by ChEMBL
LigandPNGBDBM81982(CAS_97-39-2 | cid_7333 | Di-o-tolylguanidine | DIT...)
Affinity DataKi:  164nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Institut F£R Pharmazeutische Und Medizinische Chemie

Curated by ChEMBL
LigandPNGBDBM50210191(6-benzyl-2-(benzyloxy)-8-phenethyl-6,8-diaza-bicyc...)
Affinity DataKi:  175nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
Institut F£R Pharmazeutische Und Medizinische Chemie

Curated by ChEMBL
LigandPNGBDBM50210185((1R,2R,5S )-6-benzyl-2-benzyloxy-8-methyl-6,8-diaz...)
Affinity DataKi:  585nMAssay Description:Displacement of [3H]U-69593 from kappa opioid receptor in guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
Institut F£R Pharmazeutische Und Medizinische Chemie

Curated by ChEMBL
LigandPNGBDBM50210181(6-benzyl-2-(benzyloxy)-8-butyl-6,8-diaza-bicyclo[3...)
Affinity DataKi:  1.11E+3nMAssay Description:Displacement of [3H]U-69593 from kappa opioid receptor in guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
Institut F£R Pharmazeutische Und Medizinische Chemie

Curated by ChEMBL
LigandPNGBDBM50210184((1R,2R,5S )-6-benzyl-8-(2-phenylethyl)-6,8-diazabi...)
Affinity DataKi:  1.29E+3nMAssay Description:Displacement of [3H]U-69593 from kappa opioid receptor in guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Institut F£R Pharmazeutische Und Medizinische Chemie

Curated by ChEMBL
LigandPNGBDBM50210186((1R,2R,5S )-6-benzyl-2-methoxy-8-methyl-6,8-diazab...)
Affinity DataKi:  1.35E+3nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
Institut F£R Pharmazeutische Und Medizinische Chemie

Curated by ChEMBL
LigandPNGBDBM50210187(6-benzyl-8-butyl-6,8-diaza-bicyclo[3.2.2]nonan-2-o...)
Affinity DataKi:  1.60E+3nMAssay Description:Displacement of [3H]U-69593 from kappa opioid receptor in guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
Institut F£R Pharmazeutische Und Medizinische Chemie

Curated by ChEMBL
LigandPNGBDBM50210191(6-benzyl-2-(benzyloxy)-8-phenethyl-6,8-diaza-bicyc...)
Affinity DataKi:  2.23E+3nMAssay Description:Displacement of [3H]U-69593 from kappa opioid receptor in guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Institut F£R Pharmazeutische Und Medizinische Chemie

Curated by ChEMBL
LigandPNGBDBM50210188((1R,2R,5S )-6-benzyl-8-methyl-6,8-diazabicyclo[3.2...)
Affinity DataKi:  2.40E+3nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
Institut F£R Pharmazeutische Und Medizinische Chemie

Curated by ChEMBL
LigandPNGBDBM50210183((1R,2S,5S )-6-Benzyl-8-(2-phenylethyl)-6,8-diazabi...)
Affinity DataKi:  2.46E+3nMAssay Description:Displacement of [3H]U-69593 from kappa opioid receptor in guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
Institut F£R Pharmazeutische Und Medizinische Chemie

Curated by ChEMBL
LigandPNGBDBM50210181(6-benzyl-2-(benzyloxy)-8-butyl-6,8-diaza-bicyclo[3...)
Affinity DataKi:  3.32E+3nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Institut F£R Pharmazeutische Und Medizinische Chemie

Curated by ChEMBL
LigandPNGBDBM50210192((1R,5S )-6-benzyl-8-methyl-6,8-diazabicyclo[3.2.2]...)
Affinity DataKi:  3.50E+3nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
Institut F£R Pharmazeutische Und Medizinische Chemie

Curated by ChEMBL
LigandPNGBDBM50210186((1R,2R,5S )-6-benzyl-2-methoxy-8-methyl-6,8-diazab...)
Affinity DataKi:  3.59E+3nMAssay Description:Displacement of [3H]U-69593 from kappa opioid receptor in guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
Institut F£R Pharmazeutische Und Medizinische Chemie

Curated by ChEMBL
LigandPNGBDBM50210184((1R,2R,5S )-6-benzyl-8-(2-phenylethyl)-6,8-diazabi...)
Affinity DataKi:  4.05E+3nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
Institut F£R Pharmazeutische Und Medizinische Chemie

Curated by ChEMBL
LigandPNGBDBM50210183((1R,2S,5S )-6-Benzyl-8-(2-phenylethyl)-6,8-diazabi...)
Affinity DataKi:  4.96E+3nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Institut F£R Pharmazeutische Und Medizinische Chemie

Curated by ChEMBL
LigandPNGBDBM50210194((1R,2S,5S )-6-Benzyl-8-methyl-6,8-diazabicyclo-[3....)
Affinity DataKi:  4.97E+3nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
Institut F£R Pharmazeutische Und Medizinische Chemie

Curated by ChEMBL
LigandPNGBDBM50210182(6-benzyl-2-methoxy-8-phenethyl-6,8-diaza-bicyclo[3...)
Affinity DataKi:  5.02E+3nMAssay Description:Displacement of [3H]U-69593 from kappa opioid receptor in guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
Institut F£R Pharmazeutische Und Medizinische Chemie

Curated by ChEMBL
LigandPNGBDBM50210192((1R,5S )-6-benzyl-8-methyl-6,8-diazabicyclo[3.2.2]...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]U-69593 from kappa opioid receptor in guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed