Compile Data Set for Download or QSAR
Report error Found 23 Enz. Inhib. hit(s) with all data for entry = 50038020
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Novartis Institutes of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207130(8-((6,7-dimethoxy-1-methylisoquinolin-4-yl)methyl)...)
Affinity DataIC50: 2nMAssay Description:Inhibition of human platelet PDE5 by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2012
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Novartis Institutes of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207120(CHEMBL246470 | CHEMBL537889 | 3-isobutyl-8-((6-met...)
Affinity DataIC50: 2nMAssay Description:Inhibition of human platelet PDE5 by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2012
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Novartis Institutes of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207121(N-(4-((8-((6,7-dimethoxyisoquinolin-4-yl)methyl)-1...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human platelet PDE5 by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2012
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Novartis Institutes of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207123(8-((6,7-dimethoxyisoquinolin-4-yl)methyl)-3-(3-hyd...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human platelet PDE5 by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2012
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Novartis Institutes of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207127(8-((6,7-dimethoxyisoquinolin-4-yl)methyl)-1-methyl...)
Affinity DataIC50: 8nMAssay Description:Inhibition of human platelet PDE5 by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2012
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Novartis Institutes of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207132(8-((6,7-dimethoxyisoquinolin-4-yl)methyl)-3-isobut...)
Affinity DataIC50: 9nMAssay Description:Inhibition of human platelet PDE5 by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2012
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Novartis Institutes of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207131(3-(cyclopropylmethyl)-8-((6,7-dimethoxyisoquinolin...)
Affinity DataIC50: 20nMAssay Description:Inhibition of human platelet PDE5 by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2012
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Novartis Institutes of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207137(8-(bicyclo[2.2.1]heptan-2-ylmethyl)-3-isobutyl-1-m...)
Affinity DataIC50: 25nMAssay Description:Inhibition of human platelet PDE5 by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2012
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Novartis Institutes of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207125(8-((6,7-dimethoxy-3-methylisoquinolin-4-yl)methyl)...)
Affinity DataIC50: 26nMAssay Description:Inhibition of human platelet PDE5 by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2012
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Novartis Institutes of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207124(3-(cyclohexylmethyl)-8-((6,7-dimethoxyisoquinolin-...)
Affinity DataIC50: 28nMAssay Description:Inhibition of human platelet PDE5 by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2012
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Novartis Institutes of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207126(8-((6,7-dimethoxyisoquinolin-4-yl)methyl)-1-methyl...)
Affinity DataIC50: 30nMAssay Description:Inhibition of human platelet PDE5 by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2012
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Novartis Institutes of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207129(3-(3,4-dimethoxybenzyl)-8-((6,7-dimethoxyisoquinol...)
Affinity DataIC50: 33nMAssay Description:Inhibition of human platelet PDE5 by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2012
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Novartis Institutes of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207134(3-isobutyl-8-(isoquinolin-4-ylmethyl)-1-methyl-1H-...)
Affinity DataIC50: 34nMAssay Description:Inhibition of human platelet PDE5 by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2012
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Novartis Institutes of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207128(N-(4-((8-((6,7-dimethoxyisoquinolin-4-yl)methyl)-1...)
Affinity DataIC50: 42nMAssay Description:Inhibition of human platelet PDE5 by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2012
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Novartis Institutes of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207122(3-isobutyl-8-((7-methoxyisoquinolin-4-yl)methyl)-1...)
Affinity DataIC50: 51nMAssay Description:Inhibition of human platelet PDE5 by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2012
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Novartis Institutes of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207136(8-(1-(6,7-dimethoxyisoquinolin-4-yl)ethyl)-3-isobu...)
Affinity DataIC50: 94nMAssay Description:Inhibition of human platelet PDE5 by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2012
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Novartis Institutes of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207139(8-((6,7-dimethoxyisoquinolin-4-yl)methyl)-1,3-diis...)
Affinity DataIC50: 462nMAssay Description:Inhibition of human platelet PDE5 by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2012
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Novartis Institutes of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207135(8-((6,7-dimethoxyisoquinolin-4-yl)methyl)-3-isobut...)
Affinity DataIC50: 553nMAssay Description:Inhibition of human platelet PDE5 by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2012
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Novartis Institutes of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207138(8-([1,3]dioxolo[4,5-g]isoquinolin-8-ylmethyl)-3-is...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human platelet PDE5 by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2012
Entry Details Article
PubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Human)
Novartis Institutes of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207120(CHEMBL246470 | CHEMBL537889 | 3-isobutyl-8-((6-met...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant PDE7A by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2012
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Novartis Institutes of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207120(CHEMBL246470 | CHEMBL537889 | 3-isobutyl-8-((6-met...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant PDE4D by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2012
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Novartis Institutes of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207120(CHEMBL246470 | CHEMBL537889 | 3-isobutyl-8-((6-met...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant PDE4B by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2012
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Novartis Institutes of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207120(CHEMBL246470 | CHEMBL537889 | 3-isobutyl-8-((6-met...)
Affinity DataKi:  2.30E+3nMAssay Description:Inhibition of adenosine A1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2012
Entry Details Article
PubMed