Compile Data Set for Download or QSAR
Report error Found 30 Enz. Inhib. hit(s) with all data for entry = 50019271
TargetCaspase-1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50203364(N-((S)-3-(2-(3-(1H-tetrazol-5-ylamino)-5-tert-buty...)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of human recombinant caspase 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-3(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50203361((3S)-3-(2-(3-(1H-tetrazol-5-ylamino)-5-tert-butyl-...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant caspase 3More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-3(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50203364(N-((S)-3-(2-(3-(1H-tetrazol-5-ylamino)-5-tert-buty...)
Affinity DataIC50: 6.60nMAssay Description:Inhibition of human recombinant caspase 3More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-7(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50203361((3S)-3-(2-(3-(1H-tetrazol-5-ylamino)-5-tert-butyl-...)
Affinity DataIC50: 8nMAssay Description:Inhibition of human recombinant caspase 7More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50203361((3S)-3-(2-(3-(1H-tetrazol-5-ylamino)-5-tert-butyl-...)
Affinity DataIC50: 9nMAssay Description:Inhibition of human recombinant caspase 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-8(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50203361((3S)-3-(2-(3-(1H-tetrazol-5-ylamino)-5-tert-butyl-...)
Affinity DataIC50: 14nMAssay Description:Inhibition of human recombinant caspase 8More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-3(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50160976((3S)-3-(2-(5-tert-butyl-3-((4-methyl-1,2,5-oxadiaz...)
Affinity DataIC50: 14nMAssay Description:Inhibition of human recombinant caspase 3More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-3(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50203365((3S)-3-(2-(5-tert-butyl-3-(2,3-dihydrobenzo[b][1,4...)
Affinity DataIC50: 28nMAssay Description:Inhibition of human recombinant caspase 3More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-3(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50203366((3S)-3-(2-(5-tert-butyl-2-oxo-3-(2-(thiophen-2-yl)...)
Affinity DataIC50: 50nMAssay Description:Inhibition of human recombinant caspase 3More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-7(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50203364(N-((S)-3-(2-(3-(1H-tetrazol-5-ylamino)-5-tert-buty...)
Affinity DataIC50: 64.7nMAssay Description:Inhibition of human recombinant caspase 7More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-3(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50203362((3S)-3-(2-(5-tert-butyl-3-(1-carboxy-3-methylbutyl...)
Affinity DataIC50: 100nMAssay Description:Inhibition of human recombinant caspase 3More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-7(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50160976((3S)-3-(2-(5-tert-butyl-3-((4-methyl-1,2,5-oxadiaz...)
Affinity DataIC50: 140nMAssay Description:Inhibition of human recombinant caspase 7More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-3(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50203363((3S)-3-(2-(3-(3,5-dimethoxybenzylamino)-5-tert-but...)
Affinity DataIC50: 160nMAssay Description:Inhibition of human recombinant caspase 3More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-8(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50203364(N-((S)-3-(2-(3-(1H-tetrazol-5-ylamino)-5-tert-buty...)
Affinity DataIC50: 164nMAssay Description:Inhibition of human recombinant caspase 8More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-7(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50203365((3S)-3-(2-(5-tert-butyl-3-(2,3-dihydrobenzo[b][1,4...)
Affinity DataIC50: 280nMAssay Description:Inhibition of human recombinant caspase 7More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-8(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50203366((3S)-3-(2-(5-tert-butyl-2-oxo-3-(2-(thiophen-2-yl)...)
Affinity DataIC50: 300nMAssay Description:Inhibition of human recombinant caspase 8More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50203363((3S)-3-(2-(3-(3,5-dimethoxybenzylamino)-5-tert-but...)
Affinity DataIC50: 320nMAssay Description:Inhibition of human recombinant caspase 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50203365((3S)-3-(2-(5-tert-butyl-3-(2,3-dihydrobenzo[b][1,4...)
Affinity DataIC50: 330nMAssay Description:Inhibition of human recombinant caspase 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-7(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50203363((3S)-3-(2-(3-(3,5-dimethoxybenzylamino)-5-tert-but...)
Affinity DataIC50: 800nMAssay Description:Inhibition of human recombinant caspase 7More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-7(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50203366((3S)-3-(2-(5-tert-butyl-2-oxo-3-(2-(thiophen-2-yl)...)
Affinity DataIC50: 920nMAssay Description:Inhibition of human recombinant caspase 7More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-8(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50203365((3S)-3-(2-(5-tert-butyl-3-(2,3-dihydrobenzo[b][1,4...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human recombinant caspase 8More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50203366((3S)-3-(2-(5-tert-butyl-2-oxo-3-(2-(thiophen-2-yl)...)
Affinity DataIC50: 2.31E+3nMAssay Description:Inhibition of human recombinant caspase 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-8(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50203363((3S)-3-(2-(3-(3,5-dimethoxybenzylamino)-5-tert-but...)
Affinity DataIC50: 3.05E+3nMAssay Description:Inhibition of human recombinant caspase 8More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-7(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50203362((3S)-3-(2-(5-tert-butyl-3-(1-carboxy-3-methylbutyl...)
Affinity DataIC50: 3.49E+3nMAssay Description:Inhibition of human recombinant caspase 7More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50160976((3S)-3-(2-(5-tert-butyl-3-((4-methyl-1,2,5-oxadiaz...)
Affinity DataIC50: 5.13E+3nMAssay Description:Inhibition of human recombinant caspase 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-8(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50160976((3S)-3-(2-(5-tert-butyl-3-((4-methyl-1,2,5-oxadiaz...)
Affinity DataIC50: 5.29E+3nMAssay Description:Inhibition of human recombinant caspase 8More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50203362((3S)-3-(2-(5-tert-butyl-3-(1-carboxy-3-methylbutyl...)
Affinity DataIC50: 5.49E+3nMAssay Description:Inhibition of human recombinant caspase 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-3(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50203364(N-((S)-3-(2-(3-(1H-tetrazol-5-ylamino)-5-tert-buty...)
Affinity DataIC50: 6.07E+3nMAssay Description:Inhibition of human recombinant caspase 3 in NT2 by whole cell assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-8(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50203362((3S)-3-(2-(5-tert-butyl-3-(1-carboxy-3-methylbutyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant caspase 8More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCaspase-3(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50203361((3S)-3-(2-(3-(1H-tetrazol-5-ylamino)-5-tert-butyl-...)
Affinity DataIC50: 1.94E+4nMAssay Description:Inhibition of human recombinant caspase 3 in NT2 by whole cell assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed