Compile Data Set for Download or QSAR
Report error Found 28 Enz. Inhib. hit(s) with all data for entry = 50019081
TargetMetabotropic glutamate receptor 5(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50201484(N-(6-methylpyridin-2-yl)-2-oxo-2,3-dihydrobenzo[d]...)
Affinity DataIC50: 60nMAssay Description:Antagonist activity at mGluR5 assessed as inhibition of Ca2+ efflux by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50201488(N-(3-bromophenyl)-2-oxo-2,3-dihydrobenzo[d]oxazole...)
Affinity DataIC50: 94nMAssay Description:Antagonist activity at mGluR5 assessed as inhibition of Ca2+ efflux by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50201492(2-oxo-N-m-tolyl-2,3-dihydrobenzo[d]oxazole-4-carbo...)
Affinity DataIC50: 104nMAssay Description:Antagonist activity at mGluR5 assessed as inhibition of Ca2+ efflux by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50201496(N-(3-chlorophenyl)-2-oxo-2,3-dihydrobenzo[d]oxazol...)
Affinity DataIC50: 195nMAssay Description:Antagonist activity at mGluR5 assessed as inhibition of Ca2+ efflux by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50201488(N-(3-bromophenyl)-2-oxo-2,3-dihydrobenzo[d]oxazole...)
Affinity DataKi:  56nMAssay Description:Binding affinity to mGluR5More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50201496(N-(3-chlorophenyl)-2-oxo-2,3-dihydrobenzo[d]oxazol...)
Affinity DataKi:  68nMAssay Description:Binding affinity to mGluR5More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50201484(N-(6-methylpyridin-2-yl)-2-oxo-2,3-dihydrobenzo[d]...)
Affinity DataKi:  95nMAssay Description:Binding affinity to mGluR5More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50201492(2-oxo-N-m-tolyl-2,3-dihydrobenzo[d]oxazole-4-carbo...)
Affinity DataKi:  109nMAssay Description:Binding affinity to mGluR5More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50201486(N-(2-methylthiazol-4-yl)-2-oxo-2,3-dihydrobenzo[d]...)
Affinity DataKi:  250nMAssay Description:Binding affinity to mGluR5More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50201480(2-oxo-N-(pyridin-2-yl)-2,3-dihydrobenzo[d]oxazole-...)
Affinity DataKi:  251nMAssay Description:Binding affinity to mGluR5More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50201490(N-(3-cyanophenyl)-2-oxo-2,3-dihydrobenzo[d]oxazole...)
Affinity DataKi:  327nMAssay Description:Binding affinity to mGluR5More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50201478(N-(3-chlorophenyl)-2-oxoindoline-7-carboxamide | C...)
Affinity DataKi:  397nMAssay Description:Binding affinity to mGluR5More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50201494(2-oxo-N-(3-(trifluoromethyl)phenyl)-2,3-dihydroben...)
Affinity DataKi:  485nMAssay Description:Binding affinity to mGluR5More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50201485(N-(2-methylpyrimidin-4-yl)-2-oxo-2,3-dihydrobenzo[...)
Affinity DataKi:  1.97E+3nMAssay Description:Binding affinity to mGluR5More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50201501(2-oxo-N-phenyl-2,3-dihydrobenzo[d]oxazole-4-carbox...)
Affinity DataKi:  2.20E+3nMAssay Description:Binding affinity to mGluR5More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50201500(N-(3-chlorophenyl)-3-oxo-3,4-dihydro-2H-benzo[b][1...)
Affinity DataKi:  2.90E+3nMAssay Description:Binding affinity to mGluR5More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50201479(N-(2-methylpyridin-4-yl)-2-oxo-2,3-dihydrobenzo[d]...)
Affinity DataKi:  3.10E+3nMAssay Description:Binding affinity to mGluR5More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50201493(N-(4-chlorophenyl)-2-oxo-2,3-dihydrobenzo[d]oxazol...)
Affinity DataKi:  3.80E+3nMAssay Description:Binding affinity to mGluR5More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50201491(N-(3-chlorophenyl)-2-oxo-2,3-dihydro-1H-benzo[d]im...)
Affinity DataKi:  3.90E+3nMAssay Description:Binding affinity to mGluR5More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50201489(N-(3-methoxyphenyl)-2-oxo-2,3-dihydrobenzo[d]oxazo...)
Affinity DataKi:  3.90E+3nMAssay Description:Binding affinity to mGluR5More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50201498(N-(3-chlorophenyl)-1H-indole-7-carboxamide | CHEMB...)
Affinity DataKi:  3.90E+3nMAssay Description:Binding affinity to mGluR5More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50201487(N-(3-chlorophenyl)-1-methyl-2-oxo-2,3-dihydro-1H-b...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to mGluR5More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50201483(2-acetamido-N-(3-chlorophenyl)benzamide | CHEMBL23...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to mGluR5More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50201497(N-(2-chlorophenyl)-2-oxo-2,3-dihydrobenzo[d]oxazol...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to mGluR5More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50201482(N-(3-chlorophenyl)-2-oxo-2,3-dihydrobenzo[d]oxazol...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to mGluR5More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50201495(N-(3-chlorophenyl)-3H-benzo[d][1,2,3]triazole-4-ca...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to mGluR5More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50201499(N-(3-chlorophenyl)-3H-benzo[d]imidazole-4-carboxam...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to mGluR5More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50201481(N-(3,5-dichlorophenyl)-2-oxo-2,3-dihydrobenzo[d]ox...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to mGluR5More data for this Ligand-Target Pair
In DepthDetails Article
PubMed