Compile Data Set for Download or QSAR
Report error Found 47 Enz. Inhib. hit(s) with all data for entry = 1696
LigandPNGBDBM13467((2R)-2-{[(1S)-1-carbamoyl-2-{4-[difluoro(phosphono...)
Affinity DataIC50: 0.400nMpH: 7.0 T: 2°CAssay Description:The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM13469(({4-[(2S)-2-carbamoyl-2-[(2S)-2-(1-{4-[difluoro(ph...)
Affinity DataIC50: 1.70nMpH: 7.0 T: 2°CAssay Description:The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM13507(N-[(1S)-1-(1H-1,3-benzodiazol-2-yl)-2-[3-cyano-4-(...)
Affinity DataIC50: 31nMAssay Description:The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM13508(N-[(1S)-1-(1H-1,3-benzodiazol-2-yl)-2-[3-fluoro-4-...)
Affinity DataIC50: 34nMAssay Description:The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM13493(N-[(1S)-1-(1H-1,3-benzodiazol-2-yl)-2-[4-(1,1,3-tr...)
Affinity DataIC50: 40nMAssay Description:The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM13471(({4-[(2S)-2-carbamoyl-2-[2-(1-{4-[difluoro(phospho...)
Affinity DataIC50: 42nMpH: 7.0 T: 2°CAssay Description:The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM13470([(4-{2-[(2S)-2-(1-{4-[difluoro(phosphono)methyl]ph...)
Affinity DataIC50: 46nMpH: 7.0 T: 2°CAssay Description:The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM13494(N-[(1S)-1-(1H-1,3-benzodiazol-2-yl)-2-[4-(1,1,3-tr...)
Affinity DataIC50: 51nMAssay Description:The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM13509(N-[(1S)-1-(1H-1,3-benzodiazol-2-yl)-2-[3-methyl-4-...)
Affinity DataIC50: 59nMAssay Description:The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM13475(N-[(1S)-1-(1H-benzoimidazol-2-yl)-2-[4-[(5S)-1,1,3...)
Affinity DataIC50: 59nMpH: 7.0 T: 2°CAssay Description:The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM13495(N-[(1S)-1-(1H-1,3-benzodiazol-2-yl)-2-[4-(1,1,3-tr...)
Affinity DataIC50: 66nMAssay Description:The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM13510(N-[(1S)-1-(1H-1,3-benzodiazol-2-yl)-2-[3-chloro-4-...)
Affinity DataIC50: 75nMAssay Description:The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM13496(N-[(1S)-1-(1H-1,3-benzodiazol-2-yl)-2-[4-(1,1,3-tr...)
Affinity DataIC50: 80nMAssay Description:The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM13497(N-[(1S)-1-(1H-1,3-benzodiazol-2-yl)-2-[4-(1,1,3-tr...)
Affinity DataIC50: 90nMAssay Description:The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM13498(N-[(1S)-1-(1H-1,3-benzodiazol-2-yl)-2-[4-(1,1,3-tr...)
Affinity DataIC50: 100nMAssay Description:The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM13474(N-{(1S)-2-[4-(1,1-dioxido-3-oxoisothiazolidin-5-yl...)
Affinity DataIC50: 110nMpH: 7.0 T: 2°CAssay Description:The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM13499(N-[(1S)-1-(1H-1,3-benzodiazol-2-yl)-2-[4-(1,1,3-tr...)
Affinity DataIC50: 110nMAssay Description:The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM13501(N-[(1S)-1-(1H-1,3-benzodiazol-2-yl)-2-[4-(1,1,3-tr...)
Affinity DataIC50: 120nMAssay Description:The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM13500(N-[(1S)-1-(1H-1,3-benzodiazol-2-yl)-2-[4-(1,1,3-tr...)
Affinity DataIC50: 120nMAssay Description:The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM13511(N-[(1S)-1-(1H-1,3-benzodiazol-2-yl)-2-[3-ethynyl-4...)
Affinity DataIC50: 120nMAssay Description:The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM13502(N-[(1S)-1-(1H-1,3-benzodiazol-2-yl)-2-[4-(1,1,3-tr...)
Affinity DataIC50: 160nMAssay Description:The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM13512(N-[(1S)-1-(1H-1,3-benzodiazol-2-yl)-2-[3-bromo-4-(...)
Affinity DataIC50: 170nMAssay Description:The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM13503(N-[(1S)-1-(1H-1,3-benzodiazol-2-yl)-2-[4-(1,1,3-tr...)
Affinity DataIC50: 170nMAssay Description:The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM13465((2S)-N-[(1S)-1-carbamoyl-2-{4-[(5S)-1,1,3-trioxo-1...)
Affinity DataIC50: 190nMpH: 7.0 T: 2°CAssay Description:The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM13490(N-[(1S)-1-(1H-1,3-benzodiazol-2-yl)-2-[4-(1,1,3-tr...)
Affinity DataIC50: 200nMAssay Description:The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM13504(N-[(1S)-1-(1H-1,3-benzodiazol-2-yl)-2-[4-(1,1,3-tr...)
Affinity DataIC50: 210nMAssay Description:The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM13505(N-[(1S)-1-(1H-1,3-benzodiazol-2-yl)-2-[4-(1,1,3-tr...)
Affinity DataIC50: 220nMAssay Description:The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM13473((S)-isothiazolidinone | (5S)-5-{4-[(2S)-2-(1H-1,3-...)
Affinity DataIC50: 240nMpH: 7.0 T: 2°CAssay Description:The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM13489(N-[(1S)-1-(1H-1,3-benzodiazol-2-yl)-2-[4-(1,1,3-tr...)
Affinity DataIC50: 300nMAssay Description:The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM13506(N-[(1S)-1-(1H-1,3-benzodiazol-2-yl)-2-[4-(1,1,3-tr...)
Affinity DataIC50: 300nMAssay Description:The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM13483((5S)-5-{4-[(2S)-2-(1H-1,3-benzodiazol-2-yl)-2-{[6-...)
Affinity DataIC50: 330nMAssay Description:The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM13484((5S)-5-{4-[(2S)-2-(1H-1,3-benzodiazol-2-yl)-2-[(6-...)
Affinity DataIC50: 350nMAssay Description:The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM13480((5S)-5-{4-[(2S)-2-(1H-1,3-benzodiazol-2-yl)-2-[(5-...)
Affinity DataIC50: 420nMAssay Description:The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM13485((5S)-5-{4-[(2S)-2-(1H-1,3-benzodiazol-2-yl)-2-[(6-...)
Affinity DataIC50: 500nMAssay Description:The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM13476((5S)-5-{4-[(2S)-2-(1H-1,3-benzodiazol-2-yl)-2-[(4-...)
Affinity DataIC50: 550nMpH: 7.0 T: 2°CAssay Description:The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM13492(N-[(1S)-1-(1H-1,3-benzodiazol-2-yl)-2-[4-(1,1,3-tr...)
Affinity DataIC50: 600nMAssay Description:The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM13477((5S)-5-{4-[(2S)-2-(1H-1,3-benzodiazol-2-yl)-2-{[4-...)
Affinity DataIC50: 740nMpH: 7.0 T: 2°CAssay Description:The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM13486((5S)-5-{4-[(2S)-2-(1H-1,3-benzodiazol-2-yl)-2-[(6-...)
Affinity DataIC50: 840nMAssay Description:The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM13481((5S)-5-{4-[(2S)-2-(1H-1,3-benzodiazol-2-yl)-2-[(5-...)
Affinity DataIC50: 970nMAssay Description:The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM13478((5S)-5-{4-[(2S)-2-(1H-1,3-benzodiazol-2-yl)-2-[(4-...)
Affinity DataIC50: 1.10E+3nMpH: 7.0 T: 2°CAssay Description:The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM13487((5S)-5-{4-[(2S)-2-(1H-1,3-benzodiazol-2-yl)-2-[(6-...)
Affinity DataIC50: 1.10E+3nMAssay Description:The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM13482((5S)-5-{4-[(2S)-2-(1H-1,3-benzodiazol-2-yl)-2-{[5-...)
Affinity DataIC50: 1.30E+3nMAssay Description:The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM13472(DFMP 5 | ({4-[(2S)-2-carbamoyl-2-[(2S)-2-acetamido...)
Affinity DataIC50: 1.70E+3nMpH: 7.0 T: 2°CAssay Description:The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM13479((5S)-5-{4-[(2S)-2-(1H-1,3-benzodiazol-2-yl)-2-[(6-...)
Affinity DataIC50: 1.80E+3nMpH: 7.0 T: 2°CAssay Description:The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM13488(N-[(1S)-1-(1H-1,3-benzodiazol-2-yl)-2-[4-(1,1,3-tr...)
Affinity DataIC50: 2.60E+3nMAssay Description:The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM13491(N-[(1S)-1-(1H-1,3-benzodiazol-2-yl)-2-[4-(1,1,3-tr...)
Affinity DataIC50: 3.20E+3nMAssay Description:The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM13468((2R)-2-{[(1S)-1-carbamoyl-2-phenylethyl]carbamoyl}...)
Affinity DataIC50: 3.30E+4nMpH: 7.0 T: 2°CAssay Description:The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed