Compile Data Set for Download or QSAR
Report error Found 48 Enz. Inhib. hit(s) with all data for entry = 50018156
LigandPNGBDBM50192056(Ac-Phe-[Orn-Pro-cha-Trp-Nva] | CHEMBL412031)
Affinity DataIC50: 18nMAssay Description:Antagonist activity at human C5aR in CD88 transfected RBL cells assessed as inhibition of C5a-induced glucosaminidase releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50192070(Ac-Phe-[Orn-Pro-cha-Trp-Orn] | CHEMBL405647)
Affinity DataIC50: 18nMAssay Description:Antagonist activity at human C5aR in CD88 transfected RBL cells assessed as inhibition of C5a-induced glucosaminidase releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50192059(Ac-Ala-[Orn-Pro-cha-Trp-Eag] | CHEMBL214024)
Affinity DataIC50: 19nMAssay Description:Antagonist activity at human C5aR in CD88 transfected RBL cells assessed as inhibition of C5a-induced glucosaminidase releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50192043(Ac-Phe-[Orn-Pro-cha-Trp-Thi] | CHEMBL425469)
Affinity DataIC50: 22nMAssay Description:Antagonist activity at human C5aR in CD88 transfected RBL cells assessed as inhibition of C5a-induced glucosaminidase releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50192061(Ac-Phe-[Orn-Ala-cha-Trp-Arg] | CHEMBL405646)
Affinity DataIC50: 25nMAssay Description:Antagonist activity at human C5aR in CD88 transfected RBL cells assessed as inhibition of C5a-induced glucosaminidase releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50192051(Ac-Phe-[Orn-Pro-cha-Trp-Nle] | CHEMBL374575)
Affinity DataIC50: 25nMAssay Description:Antagonist activity at human C5aR in CD88 transfected RBL cells assessed as inhibition of C5a-induced glucosaminidase releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50192062(Ac-Phe-[Orn-Pro-cha-Trp-Phe] | CHEMBL375443)
Affinity DataIC50: 26nMAssay Description:Antagonist activity at human C5aR in CD88 transfected RBL cells assessed as inhibition of C5a-induced glucosaminidase releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50192044(Ac-Phe-Orn-Pro-hle-Bta-Phe-NH2 | CHEMBL262177)
Affinity DataIC50: 27nMAssay Description:Antagonist activity at human C5aR in CD88 transfected RBL cells assessed as inhibition of C5a-induced glucosaminidase releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50111445((S)-N-((3R,6S,9S,15S,20aS)-6-((1H-indol-3-yl)methy...)
Affinity DataIC50: 29nMAssay Description:Antagonist activity at human C5aR in CD88 transfected RBL cells assessed as inhibition of C5a-induced glucosaminidase releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50192057(Ac-Phe-Orn-Pro-cha-Trp-Phe-NH2 | CHEMBL376905)
Affinity DataIC50: 31nMAssay Description:Antagonist activity at human C5aR in CD88 transfected RBL cells assessed as inhibition of C5a-induced glucosaminidase releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50111445((S)-N-((3R,6S,9S,15S,20aS)-6-((1H-indol-3-yl)methy...)
Affinity DataIC50: 31nMAssay Description:Antagonist activity at human C5aR expressed in human PMN cells assessed as inhibition of glucosaminidase releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50192066(Ac-Phe-[Orn-Pro-cha-Trp-Chg] | CHEMBL374717)
Affinity DataIC50: 38nMAssay Description:Antagonist activity at human C5aR in CD88 transfected RBL cells assessed as inhibition of C5a-induced glucosaminidase releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50192041(Hoo-Phe-Orn-Pro-hle-Pff-Phe-NH2 | CHEMBL2371928)
Affinity DataIC50: 39nMAssay Description:Antagonist activity at human C5aR in CD88 transfected RBL cells assessed as inhibition of C5a-induced glucosaminidase releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50192041(Hoo-Phe-Orn-Pro-hle-Pff-Phe-NH2 | CHEMBL2371928)
Affinity DataIC50: 41nMAssay Description:Antagonist activity at human C5aR expressed in human PMN cells assessed as inhibition of glucosaminidase releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50192038(Ac-Phe-[Orn-Pro-cha-Trp-Cha] | CHEMBL425289)
Affinity DataIC50: 45nMAssay Description:Antagonist activity at human C5aR in CD88 transfected RBL cells assessed as inhibition of C5a-induced glucosaminidase releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50192053(Ac-Phe-[Orn-Pro-cha-Trp-Ile] | CHEMBL375137)
Affinity DataIC50: 50nMAssay Description:Antagonist activity at human C5aR in CD88 transfected RBL cells assessed as inhibition of C5a-induced glucosaminidase releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50192054(Ac-Phe-[Orn-Pro-cha-Trp-1Ni] | CHEMBL374542)
Affinity DataIC50: 51nMAssay Description:Antagonist activity at human C5aR in CD88 transfected RBL cells assessed as inhibition of C5a-induced glucosaminidase releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50192037(Ac-Phe-[Orn-Pro-cha-Trp-Leu] | CHEMBL413916)
Affinity DataIC50: 54nMAssay Description:Antagonist activity at human C5aR in CD88 transfected RBL cells assessed as inhibition of C5a-induced glucosaminidase releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50192036(Ac-Phe-[Orn-Pro-cha-Trp-Hle] | CHEMBL435921)
Affinity DataIC50: 57nMAssay Description:Antagonist activity at human C5aR in CD88 transfected RBL cells assessed as inhibition of C5a-induced glucosaminidase releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50192065(Ac-Phe-Orn-Pro-hle-Mcf-Phe-NH2 | CHEMBL437988)
Affinity DataIC50: 60nMAssay Description:Antagonist activity at human C5aR in CD88 transfected RBL cells assessed as inhibition of C5a-induced glucosaminidase releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50192047(Ac-Phe-Orn-Pro-hle-Trp-Phe-NH2 | CHEMBL409045)
Affinity DataIC50: 63nMAssay Description:Antagonist activity at human C5aR in CD88 transfected RBL cells assessed as inhibition of C5a-induced glucosaminidase releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50192050(Ac-Phe-Orn-Pro-hle-Pff-Phe-NH2 | CHEMBL262181)
Affinity DataIC50: 71nMAssay Description:Antagonist activity at human C5aR in CD88 transfected RBL cells assessed as inhibition of C5a-induced glucosaminidase releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50192052(Ac-Phe-[Orn-Pro-cha-Trp-2Ni] | CHEMBL374694)
Affinity DataIC50: 76nMAssay Description:Antagonist activity at human C5aR in CD88 transfected RBL cells assessed as inhibition of C5a-induced glucosaminidase releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSubstance-K receptor(Human)
Jerini

Curated by ChEMBL
LigandPNGBDBM50111445((S)-N-((3R,6S,9S,15S,20aS)-6-((1H-indol-3-yl)methy...)
Affinity DataIC50: 87nMAssay Description:Binding affinity to NK2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50111445((S)-N-((3R,6S,9S,15S,20aS)-6-((1H-indol-3-yl)methy...)
Affinity DataIC50: 104nMAssay Description:Inhibition of C5a binding to human C5aR expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50192058(Ac-Phe-[Orn-Pro-cha-Trp-nle] | CHEMBL407439)
Affinity DataIC50: 107nMAssay Description:Antagonist activity at human C5aR in CD88 transfected RBL cells assessed as inhibition of C5a-induced glucosaminidase releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50192041(Hoo-Phe-Orn-Pro-hle-Pff-Phe-NH2 | CHEMBL2371928)
Affinity DataIC50: 111nMAssay Description:Inhibition of C5a binding to human C5aR expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50192045(Ac-Phe-Orn-Pro-hle-Dcf-Phe-NH2 | CHEMBL262178)
Affinity DataIC50: 116nMAssay Description:Antagonist activity at human C5aR in CD88 transfected RBL cells assessed as inhibition of C5a-induced glucosaminidase releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50192064(Ac-Phe-[Orn-Pro-cha-Trp-Hch] | CHEMBL219386)
Affinity DataIC50: 146nMAssay Description:Antagonist activity at human C5aR in CD88 transfected RBL cells assessed as inhibition of C5a-induced glucosaminidase releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50192063(Ac-Phe-Orn-Pro-cha-Trp-Arg-NH2 | CHEMBL373600)
Affinity DataIC50: 190nMAssay Description:Antagonist activity at human C5aR in CD88 transfected RBL cells assessed as inhibition of C5a-induced glucosaminidase releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50192060(Ac-Phe-[Orn-Pro-cha-Trp-Ocg] | CHEMBL374494)
Affinity DataIC50: 300nMAssay Description:Antagonist activity at human C5aR in CD88 transfected RBL cells assessed as inhibition of C5a-induced glucosaminidase releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50192046(Ac-Phe-[Orn-Pro-cha-Trp-Har] | CHEMBL415150)
Affinity DataIC50: 360nMAssay Description:Antagonist activity at human C5aR in CD88 transfected RBL cells assessed as inhibition of C5a-induced glucosaminidase releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Jerini

Curated by ChEMBL
LigandPNGBDBM50111445((S)-N-((3R,6S,9S,15S,20aS)-6-((1H-indol-3-yl)methy...)
Affinity DataIC50: 400nMAssay Description:Binding affinity to MC4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50192042(Ac-Phe-Orn-Pro-cha-Trp-Nle-NH2 | CHEMBL374120)
Affinity DataIC50: 463nMAssay Description:Antagonist activity at human C5aR in CD88 transfected RBL cells assessed as inhibition of C5a-induced glucosaminidase releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50192068(Ac-Phe-[Orn-Pro-cha-Trp-Cit] | CHEMBL219236)
Affinity DataIC50: 490nMAssay Description:Antagonist activity at human C5aR in CD88 transfected RBL cells assessed as inhibition of C5a-induced glucosaminidase releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50192040(Ac-Phe-Orn-Pro-cha-Trp-Arg-OH | CHEMBL409977)
Affinity DataIC50: 535nMAssay Description:Antagonist activity at human C5aR in CD88 transfected RBL cells assessed as inhibition of C5a-induced glucosaminidase releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50192049(Ac-Phe-[Orn-Pro-cha-Trp-Arg(NO2)] | CHEMBL435927)
Affinity DataIC50: 570nMAssay Description:Antagonist activity at human C5aR in CD88 transfected RBL cells assessed as inhibition of C5a-induced glucosaminidase releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSubstance-K receptor(Human)
Jerini

Curated by ChEMBL
LigandPNGBDBM50192041(Hoo-Phe-Orn-Pro-hle-Pff-Phe-NH2 | CHEMBL2371928)
Affinity DataIC50: 710nMAssay Description:Binding affinity to NK2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVasopressin V1a receptor(Human)
Jerini

Curated by ChEMBL
LigandPNGBDBM50192041(Hoo-Phe-Orn-Pro-hle-Pff-Phe-NH2 | CHEMBL2371928)
Affinity DataIC50: 740nMAssay Description:Binding affinity to V1a receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVasopressin V1a receptor(Human)
Jerini

Curated by ChEMBL
LigandPNGBDBM50111445((S)-N-((3R,6S,9S,15S,20aS)-6-((1H-indol-3-yl)methy...)
Affinity DataIC50: 740nMAssay Description:Binding affinity to V1a receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Jerini

Curated by ChEMBL
LigandPNGBDBM50111445((S)-N-((3R,6S,9S,15S,20aS)-6-((1H-indol-3-yl)methy...)
Affinity DataIC50: 2.20E+3nMAssay Description:Binding affinity to ORL1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50192039(Ac-Phe-[Orn-Pro-cha-Trp-Ala] | CHEMBL214456)
Affinity DataIC50: 6.90E+3nMAssay Description:Antagonist activity at human C5aR in CD88 transfected RBL cells assessed as inhibition of C5a-induced glucosaminidase releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50192069(Ac-Phe-[Orn-Pro-cha-Trp-Lys] | CHEMBL412008)
Affinity DataIC50: 8.70E+3nMAssay Description:Antagonist activity at human C5aR in CD88 transfected RBL cells assessed as inhibition of C5a-induced glucosaminidase releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Jerini

Curated by ChEMBL
LigandPNGBDBM50192041(Hoo-Phe-Orn-Pro-hle-Pff-Phe-NH2 | CHEMBL2371928)
Affinity DataIC50: 1.30E+4nMAssay Description:Binding affinity to MC4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50192048(Ac-Ala-[Orn-Pro-cha-Trp-Arg] | CHEMBL267491)
Affinity DataIC50: 2.30E+4nMAssay Description:Antagonist activity at human C5aR in CD88 transfected RBL cells assessed as inhibition of C5a-induced glucosaminidase releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Jerini

Curated by ChEMBL
LigandPNGBDBM50192041(Hoo-Phe-Orn-Pro-hle-Pff-Phe-NH2 | CHEMBL2371928)
Affinity DataIC50: 5.00E+4nMAssay Description:Binding affinity to ORL1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50192067(Ac-Phe-[Orn-Pro-ala-Trp-Arg] | CHEMBL407285)
Affinity DataIC50: 5.50E+4nMAssay Description:Antagonist activity at human C5aR in CD88 transfected RBL cells assessed as inhibition of C5a-induced glucosaminidase releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50192055(Ac-Phe-[Orn-Pro-cha-Ala-Arg] | CHEMBL385012)
Affinity DataIC50: 1.00E+5nMAssay Description:Antagonist activity at human C5aR in CD88 transfected RBL cells assessed as inhibition of C5a-induced glucosaminidase releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed