Compile Data Set for Download or QSAR
Report error Found 54 Enz. Inhib. hit(s) with all data for entry = 50018135
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191801((2S)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-...)
Affinity DataIC50: 3nMAssay Description:Activity at CCR2b by calcium flux based FLIPR assay in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191818((2S)-N-[3,5-bis(trifluoromethyl)benzyl]-2-cyclopro...)
Affinity DataIC50: 4nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in human monocyte cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191818((2S)-N-[3,5-bis(trifluoromethyl)benzyl]-2-cyclopro...)
Affinity DataIC50: 4nMAssay Description:Activity at CCR2b by calcium flux based FLIPR assay in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191801((2S)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-...)
Affinity DataIC50: 9nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in human monocyte cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191802((2S)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-...)
Affinity DataIC50: 11nMAssay Description:Activity at CCR2b by calcium flux based FLIPR assay in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191802((2S)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-...)
Affinity DataIC50: 12nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in human monocyte cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191823((2R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-...)
Affinity DataIC50: 13nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in human monocyte cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191818((2S)-N-[3,5-bis(trifluoromethyl)benzyl]-2-cyclopro...)
Affinity DataIC50: 14nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191800((2S)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-...)
Affinity DataIC50: 15nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in human monocyte cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191801((2S)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-...)
Affinity DataIC50: 25nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191802((2S)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-...)
Affinity DataIC50: 28nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191812((2R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-...)
Affinity DataIC50: 37nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in human monocyte cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191803((2R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-...)
Affinity DataIC50: 37nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in human monocyte cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191798(N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-cyclo...)
Affinity DataIC50: 38nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in human monocyte cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191805((R)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(2-(4-phe...)
Affinity DataIC50: 42nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in human monocyte cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191820((2S)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-3-...)
Affinity DataIC50: 47nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in human monocyte cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191815(N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-3-hydro...)
Affinity DataIC50: 48nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in human monocyte cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191814((2S)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-...)
Affinity DataIC50: 67nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191798(N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-cyclo...)
Affinity DataIC50: 69nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191817((S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-cycloprop...)
Affinity DataIC50: 72nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in human monocyte cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191807((2R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-3-...)
Affinity DataIC50: 72nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in human monocyte cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191821(N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-cyclo...)
Affinity DataIC50: 73nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in human monocyte cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191813((2S)-N-[3,5-bis(trifluoromethyl)benzyl]-2-(4-fluor...)
Affinity DataIC50: 80nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191799(2-(1-acetylpiperidin-3-yl)-N-{[3,5-bis(trifluorome...)
Affinity DataIC50: 80nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in human monocyte cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191823((2R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-...)
Affinity DataIC50: 80nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191806((2S)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-...)
Affinity DataIC50: 86nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in human monocyte cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191816(N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-4-[(1R,...)
Affinity DataIC50: 93nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in human monocyte cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191800((2S)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-...)
Affinity DataIC50: 98nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191811(N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-4-{spir...)
Affinity DataIC50: 125nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191805((R)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(2-(4-phe...)
Affinity DataIC50: 126nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191808((S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-cycloprop...)
Affinity DataIC50: 129nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in human monocyte cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191821(N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-cyclo...)
Affinity DataIC50: 160nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191816(N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-4-[(1R,...)
Affinity DataIC50: 173nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50187053((S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(4-fluoro...)
Affinity DataIC50: 180nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191803((2R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-...)
Affinity DataIC50: 193nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191820((2S)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-3-...)
Affinity DataIC50: 204nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191809((R)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(2-(4-phe...)
Affinity DataIC50: 216nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in human monocyte cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191812((2R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-...)
Affinity DataIC50: 231nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191819(2-benzyl-N-{[3,5-bis(trifluoromethyl)phenyl]methyl...)
Affinity DataIC50: 232nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in human monocyte cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191804(N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-metha...)
Affinity DataIC50: 244nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191817((S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-cycloprop...)
Affinity DataIC50: 280nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191808((S)-N-(3,5-bis(trifluoromethyl)benzyl)-2-cycloprop...)
Affinity DataIC50: 285nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191819(2-benzyl-N-{[3,5-bis(trifluoromethyl)phenyl]methyl...)
Affinity DataIC50: 298nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191807((2R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-3-...)
Affinity DataIC50: 349nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191822((2S)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-4-...)
Affinity DataIC50: 437nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191825(N-(3,5-bis(trifluoromethyl)benzyl)-2-(2-(4-(4-fluo...)
Affinity DataIC50: 462nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in human monocyte cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191827(N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-[(2-o...)
Affinity DataIC50: 525nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191826(N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-4-{spir...)
Affinity DataIC50: 570nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191806((2S)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-...)
Affinity DataIC50: 605nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50191809((R)-N-(3,5-bis(trifluoromethyl)benzyl)-2-(2-(4-phe...)
Affinity DataIC50: 642nMAssay Description:Displacement of [125I]MCP-1 from human CCR2b expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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