Compile Data Set for Download or QSAR
Report error Found 12 Enz. Inhib. hit(s) with all data for entry = 1275
TargetAcetylcholinesterase(Human)
Universita Di Siena

LigandPNGBDBM10597((1S)-7-chloro-15-ethyl-10-azatetracyclo[11.3.1.0^{...)
Affinity DataKi:  0.0260nM ΔG°:  -60.4kJ/molepH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by E llman. Inhibition of enzyme activity was measured over a substrate c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/5/2006
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Universita Di Siena

LigandPNGBDBM10595((9E)-7-(7-(1,2,3,4-Tetrahydroacridin-9-ylamino)hep...)
Affinity DataKi:  6.40nM ΔG°:  -46.8kJ/molepH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by E llman. Inhibition of enzyme activity was measured over a substrate c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/5/2006
Entry Details Article
PubMed
TargetCholinesterase(Human)
Universita Di Siena

LigandPNGBDBM8961(CHEMBL95 | Cognex | cid_1935 | CHEMBL1337960 | 1,2...)
Affinity DataKi:  7nM ΔG°:  -46.5kJ/molepH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by E llman. Inhibition of enzyme activity was measured over a substrate c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/5/2006
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAcetylcholinesterase(Human)
Universita Di Siena

LigandPNGBDBM10594((9E)-N1-(7-(1,2,3,4-Tetrahydroacridin-9-ylamino)he...)
Affinity DataKi:  15.7nM ΔG°:  -44.5kJ/molepH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by E llman. Inhibition of enzyme activity was measured over a substrate c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/5/2006
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Universita Di Siena

LigandPNGBDBM10593(N-(7-{[(1S)-1-amino-9-ethylidene-4,4,7-trimethylbi...)
Affinity DataKi:  16.5nM ΔG°:  -44.4kJ/molepH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by E llman. Inhibition of enzyme activity was measured over a substrate c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/5/2006
Entry Details Article
PubMed
TargetCholinesterase(Human)
Universita Di Siena

LigandPNGBDBM10595((9E)-7-(7-(1,2,3,4-Tetrahydroacridin-9-ylamino)hep...)
Affinity DataKi:  19.5nM ΔG°:  -44.0kJ/molepH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by E llman. Inhibition of enzyme activity was measured over a substrate c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/5/2006
Entry Details Article
PubMed
TargetCholinesterase(Human)
Universita Di Siena

LigandPNGBDBM10593(N-(7-{[(1S)-1-amino-9-ethylidene-4,4,7-trimethylbi...)
Affinity DataKi:  20.8nM ΔG°:  -43.8kJ/molepH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by E llman. Inhibition of enzyme activity was measured over a substrate c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/5/2006
Entry Details Article
PubMed
TargetCholinesterase(Human)
Universita Di Siena

LigandPNGBDBM10594((9E)-N1-(7-(1,2,3,4-Tetrahydroacridin-9-ylamino)he...)
Affinity DataKi:  30.8nM ΔG°:  -42.9kJ/molepH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by E llman. Inhibition of enzyme activity was measured over a substrate c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/5/2006
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Universita Di Siena

LigandPNGBDBM10441((+)-Huperzine A | (13E)-1-amino-13-ethylidene-11-m...)
Affinity DataKi:  47nM ΔG°:  -41.8kJ/molepH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by E llman. Inhibition of enzyme activity was measured over a substrate c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/5/2006
Entry Details Article
PubMed
TargetCholinesterase(Human)
Universita Di Siena

LigandPNGBDBM10597((1S)-7-chloro-15-ethyl-10-azatetracyclo[11.3.1.0^{...)
Affinity DataKi:  120nM ΔG°:  -39.5kJ/molepH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by E llman. Inhibition of enzyme activity was measured over a substrate c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/5/2006
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Universita Di Siena

LigandPNGBDBM8961(CHEMBL95 | Cognex | cid_1935 | CHEMBL1337960 | 1,2...)
Affinity DataKi:  137nM ΔG°:  -39.2kJ/molepH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by E llman. Inhibition of enzyme activity was measured over a substrate c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/5/2006
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCholinesterase(Human)
Universita Di Siena

LigandPNGBDBM10441((+)-Huperzine A | (13E)-1-amino-13-ethylidene-11-m...)
Affinity DataKi: >1.00E+3nM ΔG°: >-34.2kJ/molepH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by E llman. Inhibition of enzyme activity was measured over a substrate c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/5/2006
Entry Details Article
PubMed