Compile Data Set for Download or QSAR
Report error Found 18 Enz. Inhib. hit(s) with all data for entry = 50000564
TargetSigma non-opioid intracellular receptor 1(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50007314(CHEMBL104834 | [2-(3,4-Dichloro-phenyl)-ethyl]-(2-...)
Affinity DataKi:  0.490nMAssay Description:Compound was tested for the inhibitory activity against Sigma opioid receptor by using [3H](+)-3-PPP as radioligand in guinea pig brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50007316(CHEMBL101909 | (3,4-Dichloro-benzyl)-methyl-(2-pyr...)
Affinity DataKi:  1.20nMAssay Description:Compound was tested for the inhibitory activity against Sigma opioid receptor by using [3H](+)-3-PPP as radioligand in guinea pig brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50003743(CHEMBL106437 | [2-(3,4-Dichloro-phenyl)-ethyl]-met...)
Affinity DataKi:  1.30nMAssay Description:Inhibition of [3H]-(+)-3-PPP binding to sigma of guinea pig brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50003743(CHEMBL106437 | [2-(3,4-Dichloro-phenyl)-ethyl]-met...)
Affinity DataKi:  2nMAssay Description:Compound was tested for the inhibitory activity against Sigma opioid receptor by using [3H](+)-3-PPP as radioligand in guinea pig brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50007312(CHEMBL320828 | [2-(3,4-Dichloro-phenyl)-ethyl]-(2-...)
Affinity DataKi:  2.40nMAssay Description:Compound was tested for the inhibitory activity against Sigma opioid receptor by using [3H](+)-3-PPP as radioligand in guinea pig brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50007315(CHEMBL103065 | [2-(3,4-Dichloro-phenyl)-ethyl]-eth...)
Affinity DataKi:  3.10nMAssay Description:Compound was tested for the inhibitory activity against Sigma opioid receptor by using [3H](+)-3-PPP as radioligand in guinea pig brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50007313(CHEMBL102695 | [2-(3,4-Dichloro-phenyl)-ethyl]-eth...)
Affinity DataKi:  3.5nMAssay Description:Compound was tested for the inhibitory activity against Sigma opioid receptor by using [3H](+)-3-PPP as radioligand in guinea pig brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50003747(CHEMBL316988 | [2-(3,4-Dichloro-phenyl)-ethyl]-met...)
Affinity DataKi:  6nMAssay Description:Compound was tested for the inhibitory activity against Sigma opioid receptor by using [3H](+)-3-PPP as radioligand in guinea pig brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50007322(CHEMBL321329 | 2-(3,4-Dichloro-phenyl)-N-(2-pyrrol...)
Affinity DataKi:  11nMAssay Description:Compound was tested for the inhibitory activity against Sigma opioid receptor by using [3H](+)-3-PPP as radioligand in guinea pig brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50007319(CHEMBL103849 | Cyclopropylmethyl-[2-(3,4-dichloro-...)
Affinity DataKi:  38nMAssay Description:Compound was tested for the inhibitory activity against Sigma opioid receptor by using [3H](+)-3-PPP as radioligand in guinea pig brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50007321(CHEMBL316797 | [2-(3,4-Dichloro-phenyl)-ethyl]-pro...)
Affinity DataKi:  56nMAssay Description:Compound was tested for the inhibitory activity against Sigma opioid receptor by using [3H](+)-3-PPP as radioligand in guinea pig brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50003749(CHEMBL108280 | ChEMBL_172996 | [2-(3,4-Dichloro-ph...)
Affinity DataKi:  65nMAssay Description:Compound was tested for the inhibitory activity against Sigma opioid receptor by using [3H](+)-3-PPP as radioligand in guinea pig brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50007317(CHEMBL104992 | [2-(3,4-Dichloro-phenyl)-ethyl]-pro...)
Affinity DataKi:  140nMAssay Description:Compound was tested for the inhibitory activity against Sigma opioid receptor by using [3H](+)-3-PPP as radioligand in guinea pig brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50007318(CHEMBL102474 | 2-(3,4-Dichloro-phenyl)-N-(2-pyrrol...)
Affinity DataKi:  146nMAssay Description:Compound was tested for the inhibitory activity against Sigma opioid receptor by using [3H](+)-3-PPP as radioligand in guinea pig brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50007320(CHEMBL103519 | Cyclopropylmethyl-[2-(3,4-dichloro-...)
Affinity DataKi:  412nMAssay Description:Compound was tested for the inhibitory activity against Sigma opioid receptor by using [3H](+)-3-PPP as radioligand in guinea pig brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50003755((2R)-N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(p...)
Affinity DataKi:  538nMAssay Description:Compound was tested for the inhibitory activity against Sigma opioid receptor by using [3H](+)-3-PPP as radioligand in guinea pig brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2C(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50007314(CHEMBL104834 | [2-(3,4-Dichloro-phenyl)-ethyl]-(2-...)
Affinity DataKi:  6.88E+3nMAssay Description:Compound was tested for the inhibitory concentration against phencyclidine by using [3H]TCP as radioligand at PCP receptor in guinea pig brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50007314(CHEMBL104834 | [2-(3,4-Dichloro-phenyl)-ethyl]-(2-...)
Affinity DataKi:  8.51E+3nMAssay Description:Compound was tested for the inhibitory concentration against dopamine receptor D2 by using [3H]()-sulpiride) as radioligand in guinea pig brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed