Compile Data Set for Download or QSAR
Report error Found 15 Enz. Inhib. hit(s) with all data for entry = 50017515
TargetProstaglandin E2 receptor EP1 subtype(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50160917(3-[3-(2-Benzyloxy-5-chloro-phenyl)-thiophen-2-yl]-...)
Affinity DataIC50: 5nMAssay Description:Displacement of [3H]PGE2 from human EP1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 3A4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50183189(3-(3-(2-(benzyloxy)-5-chlorophenyl)pyridin-4-yl)be...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of CYP450 3A4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50183187(3-(5-(2-(benzyloxy)-5-chlorophenyl)-1H-imidazol-1-...)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of CYP450 2C9More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50183182(2''-benzyloxy-5''-chloro-[1,1';2',1'']terphenyl-3-...)
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of CYP450 2C9More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50183189(3-(3-(2-(benzyloxy)-5-chlorophenyl)pyridin-4-yl)be...)
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of CYP450 2C9More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50183188(3-(2-(2-(benzyloxy)-5-chlorophenyl)cyclopent-1-eny...)
Affinity DataIC50: 5.70E+3nMAssay Description:Inhibition of CYP450 2C9More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50183185(3-(2-(2-(benzyloxy)-5-chlorophenyl)-5-methyl-1H-py...)
Affinity DataIC50: 6.50E+3nMAssay Description:Inhibition of CYP450 2C9More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50183186(3-(2-(2-(benzyloxy)-5-bromophenyl)-5-methyl-1H-pyr...)
Affinity DataIC50: 6.80E+3nMAssay Description:Inhibition of CYP450 2C9More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50183184(3-(2-(2-(benzyloxy)-5-chlorophenyl)-1H-pyrrol-1-yl...)
Affinity DataIC50: 7.30E+3nMAssay Description:Inhibition of CYP450 2C9More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C19(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50183183(3-(3-(2-(benzyloxy)-5-chlorophenyl)pyridin-2-yl)be...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP450 2C19More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50183183(3-(3-(2-(benzyloxy)-5-chlorophenyl)pyridin-2-yl)be...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP450 2D6More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50183183(3-(3-(2-(benzyloxy)-5-chlorophenyl)pyridin-2-yl)be...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP450 2C9More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 1A2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50183183(3-(3-(2-(benzyloxy)-5-chlorophenyl)pyridin-2-yl)be...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP450 1A2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 3A4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50183183(3-(3-(2-(benzyloxy)-5-chlorophenyl)pyridin-2-yl)be...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP450 3A4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP1 subtype(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50160917(3-[3-(2-Benzyloxy-5-chloro-phenyl)-thiophen-2-yl]-...)
Affinity DataKi:  0.300nMAssay Description:Antagonist activity against PGE2 activated EP1 receptor assessed as ability to inhibit intracellular calcium mobilisation by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed