Compile Data Set for Download or QSAR
Report error Found 36 Enz. Inhib. hit(s) with all data for entry = 50017512
TargetC-C chemokine receptor type 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50183119(4-(((2-(trifluoromethyl)benzyl)(cyclohexylmethyl)a...)
Affinity DataIC50: 14nMAssay Description:Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50183091(4-((bis(cyclohexylmethyl)amino)methyl)-N-(naphthal...)
Affinity DataIC50: 18nMAssay Description:Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50183091(4-((bis(cyclohexylmethyl)amino)methyl)-N-(naphthal...)
Affinity DataIC50: 31nMAssay Description:Displacement of [125I]MDC from CCR4 expressed in human CEM cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50183102(N-(4-tert-butylthiazol-2-yl)-1-methyl-1H-indol-4-a...)
Affinity DataIC50: 37nMAssay Description:Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50183117(4-((diisobutylamino)methyl)-N-(naphthalen-1-yl)thi...)
Affinity DataIC50: 45nMAssay Description:Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50183113(4-tert-butyl-N-(naphthalen-1-yl)oxazol-2-amine | C...)
Affinity DataIC50: 80nMAssay Description:Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50183118(4-tert-butyl-N-(naphthalen-1-yl)thiazol-2-amine | ...)
Affinity DataIC50: 80nMAssay Description:Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50183096(4-isopropyl-N-(naphthalen-1-yl)thiazol-2-amine | C...)
Affinity DataIC50: 170nMAssay Description:Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50183111(4-tert-butyl-N-(5,6,7,8-tetrahydronaphthalen-1-yl)...)
Affinity DataIC50: 210nMAssay Description:Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50183100(N-(4-tert-butylthiazol-2-yl)-1-ethyl-1H-indol-4-am...)
Affinity DataIC50: 210nMAssay Description:Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50183099(N-(naphthalen-1-yl)-4-neopentylthiazol-2-amine | C...)
Affinity DataIC50: 220nMAssay Description:Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50183098(4-tert-butyl-N-(2,3-dimethylphenyl)thiazol-2-amine...)
Affinity DataIC50: 260nMAssay Description:Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50183089(N-(4-tert-butylthiazol-2-yl)quinolin-5-amine | CHE...)
Affinity DataIC50: 300nMAssay Description:Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50183107(6-(((2-(trifluoromethyl)benzyl)(cyclohexylmethyl)a...)
Affinity DataIC50: 340nMAssay Description:Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50183116(3-(((2-(trifluoromethyl)benzyl)(cyclohexylmethyl)a...)
Affinity DataIC50: 370nMAssay Description:Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50183095(4-tert-butyl-N-(2-isopropylphenyl)thiazol-2-amine ...)
Affinity DataIC50: 440nMAssay Description:Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50183104(N-(4-tert-butylthiazol-2-yl)-1H-indol-4-amine | CH...)
Affinity DataIC50: 490nMAssay Description:Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50183091(4-((bis(cyclohexylmethyl)amino)methyl)-N-(naphthal...)
Affinity DataIC50: 530nMAssay Description:Inhibition of TARC-mediated CEM cell migrationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50183110(4-((diethylamino)methyl)-N-(naphthalen-1-yl)thiazo...)
Affinity DataIC50: 800nMAssay Description:Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50183106(4-(4-tert-butylphenyl)-N-(naphthalen-1-yl)thiazol-...)
Affinity DataIC50: 900nMAssay Description:Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50183109(4-tert-butyl-N-o-tolylthiazol-2-amine | CHEMBL3822...)
Affinity DataIC50: 900nMAssay Description:Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50183088(4-((ethylamino)methyl)-N-(naphthalen-1-yl)thiazol-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50183101(N-(4-tert-butylthiazol-2-yl)isoquinolin-5-amine | ...)
Affinity DataIC50: 1.50E+3nMAssay Description:Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50183094(4-methyl-N-(naphthalen-1-yl)thiazol-2-amine | CHEM...)
Affinity DataIC50: 1.70E+3nMAssay Description:Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50183114(4-tert-butyl-N-m-tolylthiazol-2-amine | CHEMBL4382...)
Affinity DataIC50: 2.00E+3nMAssay Description:Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50183094(4-methyl-N-(naphthalen-1-yl)thiazol-2-amine | CHEM...)
Affinity DataIC50: 3.00E+3nMAssay Description:Displacement of [125I]MDC from CCR4 expressed in human CEM cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50183112(4-tert-butyl-N-phenylthiazol-2-amine | CHEMBL20610...)
Affinity DataIC50: 4.50E+3nMAssay Description:Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50183105(N-(naphthalen-1-yl)-4-phenylthiazol-2-amine | CHEM...)
Affinity DataIC50: 5.50E+3nMAssay Description:Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50183094(4-methyl-N-(naphthalen-1-yl)thiazol-2-amine | CHEM...)
Affinity DataIC50: 6.40E+3nMAssay Description:Inhibition of TARC-mediated CEM cell migrationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50183092(3-(((2-(trifluoromethyl)benzyl)(cyclohexylmethyl)a...)
Affinity DataIC50: 1.21E+4nMAssay Description:Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50183115(N,4-dimethyl-N-(naphthalen-1-yl)thiazol-2-amine | ...)
Affinity DataIC50: 2.50E+4nMAssay Description:Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50183108(N-(4-tert-butylthiazol-2-yl)quinolin-8-amine | CHE...)
Affinity DataIC50: 2.50E+4nMAssay Description:Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50183103(4-tert-butyl-N-(naphthalen-1-yl)pyrimidin-2-amine ...)
Affinity DataIC50: 2.50E+4nMAssay Description:Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50183097(3-(((2-(trifluoromethyl)benzyl)(cyclohexylmethyl)a...)
Affinity DataIC50: 2.50E+4nMAssay Description:Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50183093(4-(aminomethyl)-N-(naphthalen-1-yl)thiazol-2-amine...)
Affinity DataIC50: 2.50E+4nMAssay Description:Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50183090(4-isopropyl-2-(naphthalen-1-ylmethyl)thiazole | CH...)
Affinity DataIC50: 2.50E+4nMAssay Description:Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed