Compile Data Set for Download or QSAR
Report error Found 63 Enz. Inhib. hit(s) with all data for entry = 50017398
TargetMetabotropic glutamate receptor 5(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50181745(3-[(2-methyl-4-thiazolyl)ethynyl]benzonitrile | CH...)
Affinity DataIC50: 0.940nMAssay Description:Activity in agonist-induced phosphoinositide hydrolysis in CHO cells expressing mGluR5aMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50181753(US8609852, 78 | CHEMBL202307 | 3-[(2-methyl-4-thia...)
Affinity DataIC50: 2.01nMAssay Description:Activity in agonist-induced phosphoinositide hydrolysis in CHO cells expressing mGluR5aMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50181778(2-(4-fluorophenyl)-5-[(2-methyl-4-thiazolyl)ethyny...)
Affinity DataIC50: 10.2nMAssay Description:Activity in agonist-induced phosphoinositide hydrolysis in CHO cells expressing mGluR5aMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50181785(3-ethynyl-5-[(2-methyl-4-thiazolyl)ethynyl]pyridin...)
Affinity DataIC50: 19.2nMAssay Description:Activity in agonist-induced phosphoinositide hydrolysis in CHO cells expressing mGluR5aMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50181748(4-(2-(3-fluorophenyl)ethynyl)-2-methylthiazole | C...)
Affinity DataIC50: 23nMAssay Description:Activity in agonist-induced phosphoinositide hydrolysis in CHO cells expressing mGluR5aMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50181759(4-(3,5-difluorophenylethynyl)-2-methylthiazole | C...)
Affinity DataIC50: 25.3nMAssay Description:Activity in agonist-induced phosphoinositide hydrolysis in CHO cells expressing mGluR5aMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50181749(4-(2-methoxyphenylethynyl)-2-methylthiazole | CHEM...)
Affinity DataIC50: 36.3nMAssay Description:Activity in agonist-induced phosphoinositide hydrolysis in CHO cells expressing mGluR5aMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50084137(2-Methyl-6-phenylethynyl-pyridine | CHEMBL66654 | ...)
Affinity DataIC50: 39nMAssay Description:Activity in agonist-induced phosphoinositide hydrolysis in CHO cells expressing mGluR5aMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50181742(2-chloro-3-[(2-methyl-4-thiazolyl)ethynyl]pyridine...)
Affinity DataIC50: 45.5nMAssay Description:Activity in agonist-induced phosphoinositide hydrolysis in CHO cells expressing mGluR5aMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50181739(4-(3-methoxyphenylethynyl)-2-methylthiazole | CHEM...)
Affinity DataIC50: 49nMAssay Description:Activity in agonist-induced phosphoinositide hydrolysis in CHO cells expressing mGluR5aMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50181777(3-bromo-5-[(2-methyl-4-thiazolyl)ethynyl]pyridine ...)
Affinity DataIC50: 60nMAssay Description:Activity in agonist-induced phosphoinositide hydrolysis in CHO cells expressing mGluR5aMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50181746(3-[5-[(2-methyl-4-thiazolyl)ethynyl]-3-pyridyl]-2-...)
Affinity DataIC50: 68.6nMAssay Description:Activity in agonist-induced phosphoinositide hydrolysis in CHO cells expressing mGluR5aMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50181770(4-(3-fluorophenylethynyl)-2-thiazolylamine | CHEMB...)
Affinity DataIC50: 78.6nMAssay Description:Activity in agonist-induced phosphoinositide hydrolysis in CHO cells expressing mGluR5aMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50149802(2-Methyl-4-m-tolylethynyl-thiazole | 2-methyl-4-(m...)
Affinity DataIC50: 82.6nMAssay Description:Activity in agonist-induced phosphoinositide hydrolysis in CHO cells expressing mGluR5aMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50181779(4-(3-chlorophenylethynyl)-2-methylthiazole | CHEMB...)
Affinity DataIC50: 129nMAssay Description:Activity in agonist-induced phosphoinositide hydrolysis in CHO cells expressing mGluR5aMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50181780(4-(2-fluorophenylethynyl)-2-methylthiazole | CHEMB...)
Affinity DataIC50: 140nMAssay Description:Activity in agonist-induced phosphoinositide hydrolysis in CHO cells expressing mGluR5aMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50181789(3-(4-fluorophenyl)-5-[(2-methyl-4-thiazolyl)ethyny...)
Affinity DataIC50: 162nMAssay Description:Activity in agonist-induced phosphoinositide hydrolysis in CHO cells expressing mGluR5aMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50181760(2-ethynyl-3-[(2-methyl-4-thiazolyl)ethynyl]pyridin...)
Affinity DataIC50: 192nMAssay Description:Activity in agonist-induced phosphoinositide hydrolysis in CHO cells expressing mGluR5aMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50181738(3-(4-methoxyphenyl)-5-[(2-methyl-4-thiazolyl)ethyn...)
Affinity DataIC50: 225nMAssay Description:Activity in agonist-induced phosphoinositide hydrolysis in CHO cells expressing mGluR5aMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50181740(2-methoxy-3-[(2-methyl-4-thiazolyl)ethynyl]pyridin...)
Affinity DataIC50: 228nMAssay Description:Activity in agonist-induced phosphoinositide hydrolysis in CHO cells expressing mGluR5aMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50181771(2-methyl-4-[[3-(trifluoromethoxy)phenyl]ethynyl]th...)
Affinity DataIC50: 266nMAssay Description:Activity in agonist-induced phosphoinositide hydrolysis in CHO cells expressing mGluR5aMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50181788(2-methyl-4-(3-thienylethynyl)thiazole | CHEMBL2026...)
Affinity DataIC50: 337nMAssay Description:Activity in agonist-induced phosphoinositide hydrolysis in CHO cells expressing mGluR5aMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50181754(2-methyl-4-[[3-(trifluoromethyl)phenyl]ethynyl]thi...)
Affinity DataIC50: 413nMAssay Description:Activity in agonist-induced phosphoinositide hydrolysis in CHO cells expressing mGluR5aMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50181755(2-methoxy-5-(2-(2-methylthiazol-4-yl)ethynyl)pyrid...)
Affinity DataIC50: 426nMAssay Description:Activity in agonist-induced phosphoinositide hydrolysis in CHO cells expressing mGluR5aMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50122758(3-(2-(2-methylthiazol-4-yl)ethynyl)pyridine | 3-[(...)
Affinity DataIC50: 462nMAssay Description:Activity in agonist-induced phosphoinositide hydrolysis in CHO cells expressing mGluR5aMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50181768(2-methyl-4-(2-thienylethynyl)thiazole | CHEMBL2023...)
Affinity DataIC50: 475nMAssay Description:Activity in agonist-induced phosphoinositide hydrolysis in CHO cells expressing mGluR5aMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50181781(2-bromo-4-(3-fluorophenylethynyl)thiazole | CHEMBL...)
Affinity DataIC50: 526nMAssay Description:Activity in agonist-induced phosphoinositide hydrolysis in CHO cells expressing mGluR5aMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50181784(3-[(2-methyl-4-thiazolyl)ethynyl]phenol | CHEMBL20...)
Affinity DataIC50: 654nMAssay Description:Activity in agonist-induced phosphoinositide hydrolysis in CHO cells expressing mGluR5aMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50181787(3-[(2,5-dimethyl-4-thiazolyl)ethynyl]pyridine | CH...)
Affinity DataIC50: 698nMAssay Description:Activity in agonist-induced phosphoinositide hydrolysis in CHO cells expressing mGluR5aMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50181757(4-(3-pyridylethynyl)-2-thiazolylamine | CHEMBL3810...)
Affinity DataIC50: 789nMAssay Description:Activity in agonist-induced phosphoinositide hydrolysis in CHO cells expressing mGluR5aMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50181750(2-fluoro-5-[(2-methyl-4-thiazolyl)ethynyl]pyridine...)
Affinity DataIC50: 833nMAssay Description:Activity in agonist-induced phosphoinositide hydrolysis in CHO cells expressing mGluR5aMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50181772(5-[(2-methyl-4-thiazolyl)ethynyl]pyrimidine | CHEM...)
Affinity DataIC50: 946nMAssay Description:Activity in agonist-induced phosphoinositide hydrolysis in CHO cells expressing mGluR5aMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50181774(3-[(2-methyl-4-thiazolyl)ethynyl]benzamide | CHEMB...)
Affinity DataIC50: 1.00E+3nMAssay Description:Activity in agonist-induced phosphoinositide hydrolysis in CHO cells expressing mGluR5aMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50181769(5-fluoro-2-[(2-methyl-4-thiazolyl)ethynyl]pyridine...)
Affinity DataIC50: 1.09E+3nMAssay Description:Activity in agonist-induced phosphoinositide hydrolysis in CHO cells expressing mGluR5aMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50181786(3-[(5-ethyl-2-methyl-4-thiazolyl)ethynyl]pyridine ...)
Affinity DataIC50: 1.24E+3nMAssay Description:Activity in agonist-induced phosphoinositide hydrolysis in CHO cells expressing mGluR5aMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50181736(2-[(2-methyl-4-thiazolyl)ethynyl]pyrazine | CHEMBL...)
Affinity DataIC50: 1.83E+3nMAssay Description:Activity in agonist-induced phosphoinositide hydrolysis in CHO cells expressing mGluR5aMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50181776(N-[4-(3-pyridylethynyl)-2-thiazolyl]acetamide | CH...)
Affinity DataIC50: 1.92E+3nMAssay Description:Activity in agonist-induced phosphoinositide hydrolysis in CHO cells expressing mGluR5aMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50181767(N-[3-[(2-methyl-4-thiazolyl)ethynyl]phenyl]acetami...)
Affinity DataIC50: 2.02E+3nMAssay Description:Activity in agonist-induced phosphoinositide hydrolysis in CHO cells expressing mGluR5aMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50181741(methanesulfonic acid 5-[(2-methyl-4-thiazolyl)ethy...)
Affinity DataIC50: 2.34E+3nMAssay Description:Activity in agonist-induced phosphoinositide hydrolysis in CHO cells expressing mGluR5aMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50181773(2-ethynyl-4-(3-fluorophenylethynyl)thiazole | CHEM...)
Affinity DataIC50: 2.92E+3nMAssay Description:Activity in agonist-induced phosphoinositide hydrolysis in CHO cells expressing mGluR5aMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50181766(3-ethynyl-5-[(2-methyl-4-thiazolyl)ethynyl]pyridin...)
Affinity DataIC50: 2.95E+3nMAssay Description:Activity in agonist-induced phosphoinositide hydrolysis in CHO cells expressing mGluR5aMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50181765(4-(2-(4-fluorophenyl)ethynyl)-2-methylthiazole | C...)
Affinity DataIC50: 2.97E+3nMAssay Description:Activity in agonist-induced phosphoinositide hydrolysis in CHO cells expressing mGluR5aMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50181762((E)-3-[2-(2-methyl-4-thiazolyl)vinyl]pyridine | CH...)
Affinity DataIC50: 3.09E+3nMAssay Description:Activity in agonist-induced phosphoinositide hydrolysis in CHO cells expressing mGluR5aMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50181791(1-(2,4-difluorophenyl)-3-[4-(3-pyridylethynyl)-2-t...)
Affinity DataIC50: 1.00E+4nMAssay Description:Activity in agonist-induced phosphoinositide hydrolysis in CHO cells expressing mGluR5aMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50181782(2-methylthiazole-4-carboxylic acid 3-pyridylamide ...)
Affinity DataIC50: 1.00E+4nMAssay Description:Activity in agonist-induced phosphoinositide hydrolysis in CHO cells expressing mGluR5aMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50181783(methanesulfonic acid 3-[(2-methyl-4-thiazolyl)ethy...)
Affinity DataIC50: 1.00E+4nMAssay Description:Activity in agonist-induced phosphoinositide hydrolysis in CHO cells expressing mGluR5aMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50181737(N-[4-(3-pyridylethynyl)-2-thiazolyl]benzamide | CH...)
Affinity DataIC50: 1.00E+4nMAssay Description:Activity in agonist-induced phosphoinositide hydrolysis in CHO cells expressing mGluR5aMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50181790(3-[4-(3-fluorophenylethynyl)-2-thiazolyl]-2-propyn...)
Affinity DataIC50: 1.00E+4nMAssay Description:Activity in agonist-induced phosphoinositide hydrolysis in CHO cells expressing mGluR5aMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50181775([4-(3-pyridylethynyl)-2-thiazolyl]carbamic acid me...)
Affinity DataIC50: 1.00E+4nMAssay Description:Activity in agonist-induced phosphoinositide hydrolysis in CHO cells expressing mGluR5aMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50181764(3-[(2-methyl-4-oxazolyl)ethynyl]pyridine | CHEMBL2...)
Affinity DataIC50: 1.00E+4nMAssay Description:Activity in agonist-induced phosphoinositide hydrolysis in CHO cells expressing mGluR5aMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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