Compile Data Set for Download or QSAR
Report error Found 80 Enz. Inhib. hit(s) with all data for entry = 50017355
TargetInterstitial collagenase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50181002((S)-N-hydroxy-2,2-dimethyl-4-(4-(prop-2-ynyloxy)ph...)
Affinity DataIC50: 1nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50181006((S)-4-(4-(but-3-ynyloxy)phenylsulfonyl)-N-hydroxy-...)
Affinity DataIC50: 1nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50181002((S)-N-hydroxy-2,2-dimethyl-4-(4-(prop-2-ynyloxy)ph...)
Affinity DataIC50: 1nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50181007((S)-tert-butyl 6-(4-(3-(hydroxycarbamoyl)-2,2-dime...)
Affinity DataIC50: 2nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInterstitial collagenase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50181006((S)-4-(4-(but-3-ynyloxy)phenylsulfonyl)-N-hydroxy-...)
Affinity DataIC50: 2nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50180999((S,E)-4-(4-(but-2-enyloxy)phenylsulfonyl)-N-hydrox...)
Affinity DataIC50: 2nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM23498((3S)-4-{[4-(but-2-yn-1-yloxy)benzene]sulfonyl}-N-h...)
Affinity DataIC50: 3nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50180997((S)-tert-butyl 7-(4-(3-(hydroxycarbamoyl)-2,2-dime...)
Affinity DataIC50: 4nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50181018((S)-tert-butyl 4-(4-(3-(hydroxycarbamoyl)-2,2-dime...)
Affinity DataIC50: 4nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInterstitial collagenase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50181004((S)-N-hydroxy-2,2-dimethyl-4-(4-(penta-2,4-diynylo...)
Affinity DataIC50: 6nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInterstitial collagenase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM23498((3S)-4-{[4-(but-2-yn-1-yloxy)benzene]sulfonyl}-N-h...)
Affinity DataIC50: 7nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50181016((S)-4-(4-(7-aminohept-2-ynyloxy)phenylsulfonyl)-N-...)
Affinity DataIC50: 7nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50181013(2-((2S,5S)-4-(4-(but-2-ynyloxy)phenylsulfonyl)-5-(...)
Affinity DataIC50: 7nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInterstitial collagenase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50181003((S)-4-(4-butoxyphenylsulfonyl)-N-hydroxy-2,2-dimet...)
Affinity DataIC50: 7nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50181005((S)-4-(4-(hept-2-ynyloxy)phenylsulfonyl)-N-hydroxy...)
Affinity DataIC50: 7nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInterstitial collagenase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50180999((S,E)-4-(4-(but-2-enyloxy)phenylsulfonyl)-N-hydrox...)
Affinity DataIC50: 7nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50181001((S)-tert-butyl 5-(4-(3-(hydroxycarbamoyl)-2,2-dime...)
Affinity DataIC50: 7nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM23498((3S)-4-{[4-(but-2-yn-1-yloxy)benzene]sulfonyl}-N-h...)
Affinity DataIC50: 8nMAssay Description:Inhibition of TACEMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50181008(TMI-05 | (S)-N-hydroxy-4-(4-(4-hydroxybut-2-ynylox...)
Affinity DataIC50: 8nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50181012((S)-N-hydroxy-2,2-dimethyl-4-(4-(pent-4-ynyloxy)ph...)
Affinity DataIC50: 8nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50180995(4-({4-[(4-AMINOBUT-2-YNYL)OXY]PHENYL}SULFONYL)-N-H...)
Affinity DataIC50: 8nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50181017((S)-4-(4-(6-aminohex-2-ynyloxy)phenylsulfonyl)-N-h...)
Affinity DataIC50: 9nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50181003((S)-4-(4-butoxyphenylsulfonyl)-N-hydroxy-2,2-dimet...)
Affinity DataIC50: 9nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInterstitial collagenase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50181012((S)-N-hydroxy-2,2-dimethyl-4-(4-(pent-4-ynyloxy)ph...)
Affinity DataIC50: 11nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50180994((3S,6S)-4-(4-(but-2-ynyloxy)phenylsulfonyl)-N-hydr...)
Affinity DataIC50: 11nMAssay Description:Inhibition of TACEMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50181004((S)-N-hydroxy-2,2-dimethyl-4-(4-(penta-2,4-diynylo...)
Affinity DataIC50: 11nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50181014((S)-N-hydroxy-4-(4-(5-hydroxypent-2-ynyloxy)phenyl...)
Affinity DataIC50: 14nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50180994((3S,6S)-4-(4-(but-2-ynyloxy)phenylsulfonyl)-N-hydr...)
Affinity DataIC50: 14nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50180998((3S,6S)-4-(4-(but-2-ynyloxy)phenylsulfonyl)-N-hydr...)
Affinity DataIC50: 15nMAssay Description:Inhibition of TACEMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50181000((S)-N-hydroxy-4-(4-(7-hydroxyhept-2-ynyloxy)phenyl...)
Affinity DataIC50: 17nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInterstitial collagenase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50181013(2-((2S,5S)-4-(4-(but-2-ynyloxy)phenylsulfonyl)-5-(...)
Affinity DataIC50: 17nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50181002((S)-N-hydroxy-2,2-dimethyl-4-(4-(prop-2-ynyloxy)ph...)
Affinity DataIC50: 19nMAssay Description:Inhibition of TACEMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInterstitial collagenase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50180994((3S,6S)-4-(4-(but-2-ynyloxy)phenylsulfonyl)-N-hydr...)
Affinity DataIC50: 19nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50181013(2-((2S,5S)-4-(4-(but-2-ynyloxy)phenylsulfonyl)-5-(...)
Affinity DataIC50: 20nMAssay Description:Inhibition of TACEMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50181008(TMI-05 | (S)-N-hydroxy-4-(4-(4-hydroxybut-2-ynylox...)
Affinity DataIC50: 20nMAssay Description:Inhibition of TACEMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInterstitial collagenase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50180998((3S,6S)-4-(4-(but-2-ynyloxy)phenylsulfonyl)-N-hydr...)
Affinity DataIC50: 21nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInterstitial collagenase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50181010((3S,6S)-6-(aminomethyl)-4-(4-(but-2-ynyloxy)phenyl...)
Affinity DataIC50: 21nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50181005((S)-4-(4-(hept-2-ynyloxy)phenylsulfonyl)-N-hydroxy...)
Affinity DataIC50: 23nMAssay Description:Inhibition of TACEMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50180998((3S,6S)-4-(4-(but-2-ynyloxy)phenylsulfonyl)-N-hydr...)
Affinity DataIC50: 23nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50181010((3S,6S)-6-(aminomethyl)-4-(4-(but-2-ynyloxy)phenyl...)
Affinity DataIC50: 24nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInterstitial collagenase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50181018((S)-tert-butyl 4-(4-(3-(hydroxycarbamoyl)-2,2-dime...)
Affinity DataIC50: 26nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50180996((S)-4-(4-(5-aminopent-2-ynyloxy)phenylsulfonyl)-N-...)
Affinity DataIC50: 27nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50181017((S)-4-(4-(6-aminohex-2-ynyloxy)phenylsulfonyl)-N-h...)
Affinity DataIC50: 28nMAssay Description:Inhibition of TACEMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInterstitial collagenase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50181005((S)-4-(4-(hept-2-ynyloxy)phenylsulfonyl)-N-hydroxy...)
Affinity DataIC50: 29nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50181011((3S,6S)-6-(2-amino-2-oxoethyl)-4-(4-(but-2-ynyloxy...)
Affinity DataIC50: 29nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50181006((S)-4-(4-(but-3-ynyloxy)phenylsulfonyl)-N-hydroxy-...)
Affinity DataIC50: 32nMAssay Description:Inhibition of TACEMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInterstitial collagenase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50181009((3S,6S)-4-(4-(but-2-ynyloxy)phenylsulfonyl)-6-(2-(...)
Affinity DataIC50: 33nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInterstitial collagenase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50181008(TMI-05 | (S)-N-hydroxy-4-(4-(4-hydroxybut-2-ynylox...)
Affinity DataIC50: 33nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInterstitial collagenase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50181014((S)-N-hydroxy-4-(4-(5-hydroxypent-2-ynyloxy)phenyl...)
Affinity DataIC50: 35nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50180999((S,E)-4-(4-(but-2-enyloxy)phenylsulfonyl)-N-hydrox...)
Affinity DataIC50: 35nMAssay Description:Inhibition of TACEMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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