Compile Data Set for Download or QSAR
Report error Found 42 Enz. Inhib. hit(s) with all data for entry = 50017251
TargetMetabotropic glutamate receptor 5(Rat)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50179654(1-(3-chlorophenyl)-3-(1-ethyl-4-oxoimidazolidin-2-...)
Affinity DataIC50: 180nMAssay Description:Displacement of [3H]MPEP from mGluR5d in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50179654(1-(3-chlorophenyl)-3-(1-ethyl-4-oxoimidazolidin-2-...)
Affinity DataIC50: 250nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50179643(1-(3-chlorophenyl)-3-(3-methylthiazolidin-2-yliden...)
Affinity DataIC50: 260nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50179642(1-(3-chlorophenyl)-3-(1-ethyl-5-methyl-4-oxoimidaz...)
Affinity DataIC50: 320nMAssay Description:Displacement of [3H]MPEP from mGluR5d in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM86716(NSC_216215 | CAS_63540-28-3 | CHEMBL239800 | Fenob...)
Affinity DataIC50: 330nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50179667(1-(3-bromophenyl)-3-(1-methyl-4-oxoimidazolidin-2-...)
Affinity DataIC50: 380nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50179642(1-(3-chlorophenyl)-3-(1-ethyl-5-methyl-4-oxoimidaz...)
Affinity DataIC50: 410nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM86716(NSC_216215 | CAS_63540-28-3 | CHEMBL239800 | Fenob...)
Affinity DataIC50: 460nMAssay Description:Displacement of [3H]MPEP from mGluR5d in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50179645(1-(3-chlorophenyl)-3-(1,5-dimethyl-4-oxoimidazolid...)
Affinity DataIC50: 490nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50179669(1-(1-methyl-4-oxoimidazolidin-2-ylidene)-3-m-tolyl...)
Affinity DataIC50: 550nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50179641(1-(3-chlorophenyl)-3-(1-methylpyrrolidin-2-ylidene...)
Affinity DataIC50: 620nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50179646(1-(1-butyl-4-oxoimidazolidin-2-ylidene)-3-(3-chlor...)
Affinity DataIC50: 680nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50179640(1-(3-chlorophenyl)-3-(1-oxo-hexahydropyrrolo[1,2-e...)
Affinity DataIC50: 800nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50179643(1-(3-chlorophenyl)-3-(3-methylthiazolidin-2-yliden...)
Affinity DataIC50: 1.20E+3nMAssay Description:Displacement of [3H]MPEP from mGluR5d in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50179646(1-(1-butyl-4-oxoimidazolidin-2-ylidene)-3-(3-chlor...)
Affinity DataIC50: 1.30E+3nMAssay Description:Displacement of [3H]MPEP from mGluR5d in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50179645(1-(3-chlorophenyl)-3-(1,5-dimethyl-4-oxoimidazolid...)
Affinity DataIC50: 1.30E+3nMAssay Description:Displacement of [3H]MPEP from mGluR5d in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50179644(1-(1-methyl-4-oxo-5-phenylimidazolidin-2-ylidene)-...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50179640(1-(3-chlorophenyl)-3-(1-oxo-hexahydropyrrolo[1,2-e...)
Affinity DataIC50: 1.60E+3nMAssay Description:Displacement of [3H]MPEP from mGluR5d in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50179657((E)-1-(1-methyl-4-oxoimidazolidin-2-ylidene)-3-(6-...)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50179641(1-(3-chlorophenyl)-3-(1-methylpyrrolidin-2-ylidene...)
Affinity DataIC50: 2.00E+3nMAssay Description:Displacement of [3H]MPEP from mGluR5d in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50179666(3-chloro-N-(1-methyl-4-oxoimidazolidin-2-ylidene)b...)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50179662(1-(3-methoxyphenyl)-3-(1-methyl-4-oxoimidazolidin-...)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50179665(1-(1-methyl-4-oxoimidazolidin-2-ylidene)-3-(5-meth...)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50179652(1-(3-cyanophenyl)-3-(1-methyl-4-oxoimidazolidin-2-...)
Affinity DataIC50: 3.40E+3nMAssay Description:Displacement of [3H]MPEP from mGluR5d in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50179652(1-(3-cyanophenyl)-3-(1-methyl-4-oxoimidazolidin-2-...)
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50179660(1-(1-oxo-hexahydropyrrolo[1,2-e]imidazol-3-ylidene...)
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50179668(1-(1-methyl-4-oxoimidazolidin-2-ylidene)-3-(thioph...)
Affinity DataIC50: 4.90E+3nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50201659((E)-1-(1-methyl-4-oxoimidazolidin-2-ylidene)-3-phe...)
Affinity DataIC50: 4.90E+3nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50179655(1-(3-chlorophenyl)-3-(1-methyl-1H-imidazol-2-yl)ur...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50179659(1-(1-oxo-hexahydropyrrolo[1,2-e]imidazol-3-ylidene...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50179661(1-(2,3-dimethylphenyl)-3-(1-oxo-hexahydropyrrolo[1...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50179663(1-(3-chlorophenyl)-3-(1-methyl-5-oxoimidazolidin-2...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50179658(1-(2,5-dimethylphenyl)-3-(1-oxo-hexahydropyrrolo[1...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50179656(1-(3-chloro-4-methylphenyl)-3-(1-oxo-hexahydropyrr...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50179663(1-(3-chlorophenyl)-3-(1-methyl-5-oxoimidazolidin-2...)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [3H]MPEP from mGluR5d in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50179664(Xilobam | 1-(2,6-dimethylphenyl)-3-(1-methylpyrrol...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50179655(1-(3-chlorophenyl)-3-(1-methyl-1H-imidazol-2-yl)ur...)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [3H]MPEP from mGluR5d in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50179653(1-(4-chlorophenyl)-3-(1-oxo-hexahydropyrrolo[1,2-e...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50179644(1-(1-methyl-4-oxo-5-phenylimidazolidin-2-ylidene)-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [3H]MPEP from mGluR5d in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50179649(1-hexyl-3-(1-methyl-4-oxoimidazolidin-2-ylidene)ur...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50179647(methyl 3-(3-(1-methyl-4-oxoimidazolidin-2-ylidene)...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50179648(1-(3,5-dichlorophenyl)-3-(1-methyl-4-oxoimidazolid...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed