Compile Data Set for Download or QSAR
Report error Found 70 Enz. Inhib. hit(s) with all data for entry = 50017211
Target5-hydroxytryptamine receptor 2B(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50179073((4R,9aR)-6-Cyclopropylmethoxymethyl-4-methyl-1,2,3...)
Affinity DataEC50:  23nMAssay Description:Efficacy against human recombinant 5HT2B receptor induced intracellular calcium mobilization in CHO cells by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50179073((4R,9aR)-6-Cyclopropylmethoxymethyl-4-methyl-1,2,3...)
Affinity DataEC50:  15nMAssay Description:Efficacy against human recombinant 5HT2C receptor induced intracellular calcium mobilization in CHO cells by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50169261((4R,10aS)-7-chloro-4,6-dimethyl-1,2,3,4,10,10a-hex...)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of hERG potassium channel expressed in CHO cells by whole cell patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50179086((4R,9aR)-4,6-dimethyl-1,2,3,4,9,9a-hexahydro-2,4a,...)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of hERG potassium channel expressed in CHO cells by whole cell patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50179073((4R,9aR)-6-Cyclopropylmethoxymethyl-4-methyl-1,2,3...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of hERG potassium channel expressed in CHO cells by whole cell patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50179080((4R,9aR)-6-chloro-4-methyl-1,2,3,4,9,9a-hexahydro-...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of hERG potassium channel expressed in CHO cells by whole cell patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50169264((4R,10aR)-7-chloro-4,6-dimethyl-1,2,3,4,10,10a-hex...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]5HT from human recombinant 5HT2C receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50179077((4R,9aR)-6-bromo-4-methyl-1,2,3,4,9,9a-hexahydro-2...)
Affinity DataKi:  0.800nMAssay Description:Displacement of [3H]5HT from human recombinant 5HT2C receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50179080((4R,9aR)-6-chloro-4-methyl-1,2,3,4,9,9a-hexahydro-...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]5HT from human recombinant 5HT2C receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50169261((4R,10aS)-7-chloro-4,6-dimethyl-1,2,3,4,10,10a-hex...)
Affinity DataKi:  1.90nMAssay Description:Displacement of [3H]5HT from human recombinant 5HT2C receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50179087((4R,9aR)-6-[1-((S)-ethoxy)-ethyl]-4-methyl-1,2,3,4...)
Affinity DataKi:  2.30nMAssay Description:Displacement of [3H]5HT from human recombinant 5HT2C receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50169264((4R,10aR)-7-chloro-4,6-dimethyl-1,2,3,4,10,10a-hex...)
Affinity DataKi:  2.60nMAssay Description:Displacement of [125I]DOI from human recombinant 5HT2A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50179086((4R,9aR)-4,6-dimethyl-1,2,3,4,9,9a-hexahydro-2,4a,...)
Affinity DataKi:  2.70nMAssay Description:Displacement of [3H]5HT from human recombinant 5HT2C receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50169264((4R,10aR)-7-chloro-4,6-dimethyl-1,2,3,4,10,10a-hex...)
Affinity DataKi:  3.20nMAssay Description:Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50179073((4R,9aR)-6-Cyclopropylmethoxymethyl-4-methyl-1,2,3...)
Affinity DataKi:  3.60nMAssay Description:Displacement of [3H]5HT from human recombinant 5HT2C receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50179079((4R,9aR)-4-methyl-6-trifluoromethyl-1,2,3,4,9,9a-h...)
Affinity DataKi:  14nMAssay Description:Displacement of [3H]5HT from human recombinant 5HT2C receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50179078((4R,9aR)-6-methoxymethyl-4-methyl-1,2,3,4,9,9a-hex...)
Affinity DataKi:  16nMAssay Description:Displacement of [3H]5HT from human recombinant 5HT2C receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50169261((4R,10aS)-7-chloro-4,6-dimethyl-1,2,3,4,10,10a-hex...)
Affinity DataKi:  19nMAssay Description:Displacement of [125I]DOI from human recombinant 5HT2A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50179076((4R,9aS)-6-bromo-4-methyl-1,2,3,4,9,9a-hexahydro-2...)
Affinity DataKi:  21nMAssay Description:Displacement of [3H]5HT from human recombinant 5HT2C receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50179083(1-((4R,9aR)-4-methyl-1,2,3,4,9,9a-hexahydro-2,4a,5...)
Affinity DataKi:  39nMAssay Description:Displacement of [3H]5HT from human recombinant 5HT2C receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50169261((4R,10aS)-7-chloro-4,6-dimethyl-1,2,3,4,10,10a-hex...)
Affinity DataKi:  40nMAssay Description:Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50179080((4R,9aR)-6-chloro-4-methyl-1,2,3,4,9,9a-hexahydro-...)
Affinity DataKi:  42nMAssay Description:Displacement of [125I]DOI from human recombinant 5HT2A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50179079((4R,9aR)-4-methyl-6-trifluoromethyl-1,2,3,4,9,9a-h...)
Affinity DataKi:  43nMAssay Description:Displacement of [125I]DOI from human recombinant 5HT2A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50179080((4R,9aR)-6-chloro-4-methyl-1,2,3,4,9,9a-hexahydro-...)
Affinity DataKi:  48nMAssay Description:Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50179081((4R,9aS)-6-chloro-4-methyl-1,2,3,4,9,9a-hexahydro-...)
Affinity DataKi:  52nMAssay Description:Displacement of [3H]5HT from human recombinant 5HT2C receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50179077((4R,9aR)-6-bromo-4-methyl-1,2,3,4,9,9a-hexahydro-2...)
Affinity DataKi:  53nMAssay Description:Displacement of [125I]DOI from human recombinant 5HT2A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50179081((4R,9aS)-6-chloro-4-methyl-1,2,3,4,9,9a-hexahydro-...)
Affinity DataKi:  54nMAssay Description:Displacement of [125I]DOI from human recombinant 5HT2A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50179082(((4R,9aR)-4-methyl-1,2,3,4,9,9a-hexahydro-2,4a,5-t...)
Affinity DataKi:  54nMAssay Description:Displacement of [3H]5HT from human recombinant 5HT2C receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50179076((4R,9aS)-6-bromo-4-methyl-1,2,3,4,9,9a-hexahydro-2...)
Affinity DataKi:  58nMAssay Description:Displacement of [125I]DOI from human recombinant 5HT2A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50179085((4R,9aR)-4-methyl-1,2,3,4,9,9a-hexahydro-2,4a,5-tr...)
Affinity DataKi:  60nMAssay Description:Displacement of [3H]5HT from human recombinant 5HT2C receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50179087((4R,9aR)-6-[1-((S)-ethoxy)-ethyl]-4-methyl-1,2,3,4...)
Affinity DataKi:  65nMAssay Description:Displacement of [125I]DOI from human recombinant 5HT2A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50179079((4R,9aR)-4-methyl-6-trifluoromethyl-1,2,3,4,9,9a-h...)
Affinity DataKi:  68nMAssay Description:Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50179073((4R,9aR)-6-Cyclopropylmethoxymethyl-4-methyl-1,2,3...)
Affinity DataKi:  74nMAssay Description:Displacement of [125I]DOI from human recombinant 5HT2A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50179086((4R,9aR)-4,6-dimethyl-1,2,3,4,9,9a-hexahydro-2,4a,...)
Affinity DataKi:  77nMAssay Description:Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50179077((4R,9aR)-6-bromo-4-methyl-1,2,3,4,9,9a-hexahydro-2...)
Affinity DataKi:  81nMAssay Description:Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50179084((4R,9aR)-6-[1-((R)-ethoxy)-ethyl]-4-methyl-1,2,3,4...)
Affinity DataKi:  93nMAssay Description:Displacement of [3H]5HT from human recombinant 5HT2C receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50179074((4R,9aR)-6-methoxy-4-methyl-1,2,3,4,9,9a-hexahydro...)
Affinity DataKi:  104nMAssay Description:Displacement of [3H]5HT from human recombinant 5HT2C receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50179075(6-chloro-1,2,3,4,9,9a-hexahydro-2,4a,5-triaza-fluo...)
Affinity DataKi:  131nMAssay Description:Displacement of [3H]5HT from human recombinant 5HT2C receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50179086((4R,9aR)-4,6-dimethyl-1,2,3,4,9,9a-hexahydro-2,4a,...)
Affinity DataKi:  136nMAssay Description:Displacement of [125I]DOI from human recombinant 5HT2A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50179076((4R,9aS)-6-bromo-4-methyl-1,2,3,4,9,9a-hexahydro-2...)
Affinity DataKi:  166nMAssay Description:Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50179073((4R,9aR)-6-Cyclopropylmethoxymethyl-4-methyl-1,2,3...)
Affinity DataKi:  174nMAssay Description:Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50179075(6-chloro-1,2,3,4,9,9a-hexahydro-2,4a,5-triaza-fluo...)
Affinity DataKi:  217nMAssay Description:Displacement of [125I]DOI from human recombinant 5HT2A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50179081((4R,9aS)-6-chloro-4-methyl-1,2,3,4,9,9a-hexahydro-...)
Affinity DataKi:  217nMAssay Description:Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50179075(6-chloro-1,2,3,4,9,9a-hexahydro-2,4a,5-triaza-fluo...)
Affinity DataKi:  221nMAssay Description:Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50179087((4R,9aR)-6-[1-((S)-ethoxy)-ethyl]-4-methyl-1,2,3,4...)
Affinity DataKi:  295nMAssay Description:Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50179073((4R,9aR)-6-Cyclopropylmethoxymethyl-4-methyl-1,2,3...)
Affinity DataKi: >360nMAssay Description:Binding affinity to 5HT1D receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50179078((4R,9aR)-6-methoxymethyl-4-methyl-1,2,3,4,9,9a-hex...)
Affinity DataKi:  379nMAssay Description:Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50179083(1-((4R,9aR)-4-methyl-1,2,3,4,9,9a-hexahydro-2,4a,5...)
Affinity DataKi:  392nMAssay Description:Displacement of [125I]DOI from human recombinant 5HT2A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50179074((4R,9aR)-6-methoxy-4-methyl-1,2,3,4,9,9a-hexahydro...)
Affinity DataKi:  440nMAssay Description:Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50179074((4R,9aR)-6-methoxy-4-methyl-1,2,3,4,9,9a-hexahydro...)
Affinity DataKi:  511nMAssay Description:Displacement of [125I]DOI from human recombinant 5HT2A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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