Compile Data Set for Download or QSAR
Report error Found 43 Enz. Inhib. hit(s) with all data for entry = 1926
TargetcAMP-dependent protein kinase catalytic subunit alpha(Bovine)
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15211(CHEMBL104264 | H89 | N-(2-{[(2E)-3-(4-bromophenyl)...)
Affinity DataIC50: 73nMAssay Description:The recombinant alpha catalytic subunit of bovine PKA was assayed with a peptide substrate and test compound in the presence of 40 uM ATP/ [gamma-33P...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetcAMP-dependent protein kinase catalytic subunit alpha(Bovine)
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15218(N-{[(2S,4S)-4-[(4-chlorophenyl)methoxy]pyrrolidin-...)
Affinity DataIC50: 170nMAssay Description:The recombinant alpha catalytic subunit of bovine PKA was assayed with a peptide substrate and test compound in the presence of 40 uM ATP/ [gamma-33P...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Bovine)
Uk Centre For Cancer Therapeutics

LigandPNGBDBM16222(N-[2-({2-[(4-chlorobenzyl)oxy]ethyl}amino)ethyl]is...)
Affinity DataIC50: 170nMpH: 7.2 T: 2°CAssay Description:The recombinant alpha catalytic subunit of bovine PKA was assayed with a peptide substrate and test compound in the presence of 40 uM ATP/ [gamma-33P...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetRAC-beta serine/threonine-protein kinase(Human)
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15198(Isoquinoline-5-sulfonic acid (2-(2-(3,4-dichlorobe...)
Affinity DataIC50: 210nMpH: 7.2 T: 2°CAssay Description:The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRAC-beta serine/threonine-protein kinase(Human)
Uk Centre For Cancer Therapeutics

LigandPNGBDBM16222(N-[2-({2-[(4-chlorobenzyl)oxy]ethyl}amino)ethyl]is...)
Affinity DataIC50: 260nMpH: 7.2 T: 2°CAssay Description:The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetcAMP-dependent protein kinase catalytic subunit alpha(Bovine)
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15220(N-[(3S,5S)-5-{[(4-chlorophenyl)methoxy]methyl}pyrr...)
Affinity DataIC50: 320nMAssay Description:The recombinant alpha catalytic subunit of bovine PKA was assayed with a peptide substrate and test compound in the presence of 40 uM ATP/ [gamma-33P...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRAC-beta serine/threonine-protein kinase(Human)
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15196(Isoquinoline-5-sulfonic acid (2-(2-(3-chlorobenzyl...)
Affinity DataIC50: 370nMpH: 7.2 T: 2°CAssay Description:The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Bovine)
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15216(Isoquinoline-5-sulfonic acid (2S,4R)-(4-(4-chlorob...)
Affinity DataIC50: 400nMAssay Description:The recombinant alpha catalytic subunit of bovine PKA was assayed with a peptide substrate and test compound in the presence of 40 uM ATP/ [gamma-33P...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Bovine)
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15196(Isoquinoline-5-sulfonic acid (2-(2-(3-chlorobenzyl...)
Affinity DataIC50: 410nMpH: 7.2 T: 2°CAssay Description:The recombinant alpha catalytic subunit of bovine PKA was assayed with a peptide substrate and test compound in the presence of 40 uM ATP/ [gamma-33P...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Bovine)
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15215(N-[(3S,5S)-5-{[(4-chlorophenyl)methoxy]methyl}pyrr...)
Affinity DataIC50: 420nMAssay Description:The recombinant alpha catalytic subunit of bovine PKA was assayed with a peptide substrate and test compound in the presence of 40 uM ATP/ [gamma-33P...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRAC-beta serine/threonine-protein kinase(Human)
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15218(N-{[(2S,4S)-4-[(4-chlorophenyl)methoxy]pyrrolidin-...)
Affinity DataIC50: 480nMAssay Description:The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRAC-beta serine/threonine-protein kinase(Human)
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15221(N-[(3S,5S)-5-{[(4-chlorophenyl)methoxy]methyl}pyrr...)
Affinity DataIC50: 520nMAssay Description:The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRAC-beta serine/threonine-protein kinase(Human)
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15192(N-[2-({2-[(2-methylphenyl)methoxy]ethyl}amino)ethy...)
Affinity DataIC50: 570nMpH: 7.2 T: 2°CAssay Description:The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRAC-beta serine/threonine-protein kinase(Human)
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15211(CHEMBL104264 | H89 | N-(2-{[(2E)-3-(4-bromophenyl)...)
Affinity DataIC50: 590nMAssay Description:The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRAC-beta serine/threonine-protein kinase(Human)
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15215(N-[(3S,5S)-5-{[(4-chlorophenyl)methoxy]methyl}pyrr...)
Affinity DataIC50: 780nMAssay Description:The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRAC-beta serine/threonine-protein kinase(Human)
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15195(N-[2-({2-[(2-chlorophenyl)methoxy]ethyl}amino)ethy...)
Affinity DataIC50: 960nMpH: 7.2 T: 2°CAssay Description:The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Bovine)
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15195(N-[2-({2-[(2-chlorophenyl)methoxy]ethyl}amino)ethy...)
Affinity DataIC50: 1.00E+3nMpH: 7.2 T: 2°CAssay Description:The recombinant alpha catalytic subunit of bovine PKA was assayed with a peptide substrate and test compound in the presence of 40 uM ATP/ [gamma-33P...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRAC-beta serine/threonine-protein kinase(Human)
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15193(N-[2-({2-[(3-methylphenyl)methoxy]ethyl}amino)ethy...)
Affinity DataIC50: 1.10E+3nMpH: 7.2 T: 2°CAssay Description:The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRAC-beta serine/threonine-protein kinase(Human)
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15191(N-(2-{[2-(benzyloxy)ethyl]amino}ethyl)isoquinoline...)
Affinity DataIC50: 1.17E+3nMpH: 7.2 T: 2°CAssay Description:The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Bovine)
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15221(N-[(3S,5S)-5-{[(4-chlorophenyl)methoxy]methyl}pyrr...)
Affinity DataIC50: 1.30E+3nMAssay Description:The recombinant alpha catalytic subunit of bovine PKA was assayed with a peptide substrate and test compound in the presence of 40 uM ATP/ [gamma-33P...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRAC-beta serine/threonine-protein kinase(Human)
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15194(Isoquinoline-5-sulfonic acid (2-(2-(4-methylbenzyl...)
Affinity DataIC50: 1.53E+3nMpH: 7.2 T: 2°CAssay Description:The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRAC-beta serine/threonine-protein kinase(Human)
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15219(Isoquinoline-5-sulfonic acid (2R*,5S*)-(5-(4-chlor...)
Affinity DataIC50: 1.70E+3nMAssay Description:The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRAC-beta serine/threonine-protein kinase(Human)
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15216(Isoquinoline-5-sulfonic acid (2S,4R)-(4-(4-chlorob...)
Affinity DataIC50: 1.70E+3nMAssay Description:The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRAC-beta serine/threonine-protein kinase(Human)
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15200(Isoquinoline-5-sulfonic acid (2-(2-(3-methoxybenzy...)
Affinity DataIC50: 2.20E+3nMpH: 7.2 T: 2°CAssay Description:The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRAC-beta serine/threonine-protein kinase(Human)
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15220(N-[(3S,5S)-5-{[(4-chlorophenyl)methoxy]methyl}pyrr...)
Affinity DataIC50: 2.60E+3nMAssay Description:The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRAC-beta serine/threonine-protein kinase(Human)
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15201(N-[2-({2-[(4-methoxyphenyl)methoxy]ethyl}amino)eth...)
Affinity DataIC50: 2.90E+3nMpH: 7.2 T: 2°CAssay Description:The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRAC-beta serine/threonine-protein kinase(Human)
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15217(Isoquinoline-5-sulfonic acid (2S,4S)-(4-(benzyloxy...)
Affinity DataIC50: 3.40E+3nMAssay Description:The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRAC-beta serine/threonine-protein kinase(Human)
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15208(Isoquinoline-5-sulfonic acid pyrrolidin-3-ylamide ...)
Affinity DataIC50: 3.90E+3nMAssay Description:The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Bovine)
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15204(N-(piperidin-4-yl)isoquinoline-5-sulfonamide | Iso...)
Affinity DataIC50: 3.90E+3nMpH: 7.2 T: 2°CAssay Description:The recombinant alpha catalytic subunit of bovine PKA was assayed with a peptide substrate and test compound in the presence of 40 uM ATP/ [gamma-33P...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRAC-beta serine/threonine-protein kinase(Human)
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15202(N-(3-aminopropyl)isoquinoline-5-sulfonamide | isoq...)
Affinity DataIC50: 4.80E+3nMpH: 7.2 T: 2°CAssay Description:The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRAC-beta serine/threonine-protein kinase(Human)
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15214(N-[(3R,5S)-5-{[(4-chlorophenyl)methoxy]methyl}pyrr...)
Affinity DataIC50: 5.20E+3nMAssay Description:The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Bovine)
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15210(N-[2-(methylamino)ethyl]isoquinoline-5-sulfonamide...)
Affinity DataIC50: 5.30E+3nMAssay Description:The recombinant alpha catalytic subunit of bovine PKA was assayed with a peptide substrate and test compound in the presence of 40 uM ATP/ [gamma-33P...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetcAMP-dependent protein kinase catalytic subunit alpha(Bovine)
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15207(Isoquinoline-5-sulfonic acid trans-(4-aminocyclohe...)
Affinity DataIC50: 5.70E+3nMAssay Description:The recombinant alpha catalytic subunit of bovine PKA was assayed with a peptide substrate and test compound in the presence of 40 uM ATP/ [gamma-33P...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRAC-beta serine/threonine-protein kinase(Human)
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15212(N-[4-(benzylamino)cyclohexyl]isoquinoline-5-sulfon...)
Affinity DataIC50: 6.60E+3nMAssay Description:The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRAC-beta serine/threonine-protein kinase(Human)
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15199(N-[2-({2-[(2-methoxyphenyl)methoxy]ethyl}amino)eth...)
Affinity DataIC50: 6.60E+3nMpH: 7.2 T: 2°CAssay Description:The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRAC-beta serine/threonine-protein kinase(Human)
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15210(N-[2-(methylamino)ethyl]isoquinoline-5-sulfonamide...)
Affinity DataIC50: 7.60E+3nMAssay Description:The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRAC-beta serine/threonine-protein kinase(Human)
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15207(Isoquinoline-5-sulfonic acid trans-(4-aminocyclohe...)
Affinity DataIC50: 8.10E+3nMAssay Description:The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRAC-beta serine/threonine-protein kinase(Human)
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15204(N-(piperidin-4-yl)isoquinoline-5-sulfonamide | Iso...)
Affinity DataIC50: 8.70E+3nMpH: 7.2 T: 2°CAssay Description:The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRAC-beta serine/threonine-protein kinase(Human)
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15213(Isoquinoline-5-sulfonic acid (3-(4-chlorobenzyloxy...)
Affinity DataIC50: 1.20E+4nMAssay Description:The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRAC-beta serine/threonine-protein kinase(Human)
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15203(Isoquinoline-5-sulfonic acid piperazin-1 ylamide |...)
Affinity DataIC50: 2.30E+4nMpH: 7.2 T: 2°CAssay Description:The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRAC-beta serine/threonine-protein kinase(Human)
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15205(Isoquinoline-5-sulfonic acid (4-aminopiperidin-1-y...)
Affinity DataIC50: 3.00E+4nMpH: 7.2 T: 2°CAssay Description:The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRAC-beta serine/threonine-protein kinase(Human)
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15209(N-[(2S)-pyrrolidin-2-ylmethyl]isoquinoline-5-sulfo...)
Affinity DataIC50: 3.90E+4nMAssay Description:The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRAC-beta serine/threonine-protein kinase(Human)
Uk Centre For Cancer Therapeutics

LigandPNGBDBM15206(Isoquinoline-5-sulfonic acid (piperidin-4-ylmethyl...)
Affinity DataIC50: 5.70E+4nMAssay Description:The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed