Compile Data Set for Download or QSAR
Report error Found 38 Enz. Inhib. hit(s) with all data for entry = 50016965
TargetCytochrome P450 2D6(Human)
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50175833(3-(4-((1H-imidazol-4-yl)methyl)piperidin-1-yl)-N-(...)
Affinity DataIC50: 40nMAssay Description:Inhibition of CYP2D6 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50175828(3-(4-((1H-imidazol-4-yl)methyl)piperidin-1-yl)-N-(...)
Affinity DataIC50: 100nMAssay Description:Inhibition of CYP2D6 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50175843(3-(4-((1H-imidazol-4-yl)methyl)piperidin-1-yl)-N-(...)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50175828(3-(4-((1H-imidazol-4-yl)methyl)piperidin-1-yl)-N-(...)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50175833(3-(4-((1H-imidazol-4-yl)methyl)piperidin-1-yl)-N-(...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H3 receptor(Human)
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50175843(3-(4-((1H-imidazol-4-yl)methyl)piperidin-1-yl)-N-(...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in human brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM22542(4-(1H-imidazol-4-ylmethyl)piperidine | 4-(1H-imida...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetHistamine H3 receptor(Human)
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50175833(3-(4-((1H-imidazol-4-yl)methyl)piperidin-1-yl)-N-(...)
Affinity DataKi:  1.70nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in human brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H3 receptor(Human)
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50175828(3-(4-((1H-imidazol-4-yl)methyl)piperidin-1-yl)-N-(...)
Affinity DataKi:  1.90nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in human brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50175827(4-((1H-imidazol-4-yl)methyl)-1-heptylpiperidine | ...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50175836(N-(3-(4-((1H-imidazol-4-yl)methyl)piperidin-1-yl)p...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50175851(3-(4-((1H-imidazol-4-yl)methyl)piperidin-1-yl)-N-p...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50175846(4-((1H-imidazol-4-yl)methyl)-1-(3-(3-chlorophenoxy...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50175831(methyl 4-(3-(4-((1H-imidazol-4-yl)methyl)piperidin...)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50175830(3-(4-((1H-imidazol-4-yl)methyl)piperidin-1-yl)-N-(...)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50175829(3-(4-((1H-imidazol-4-yl)methyl)piperidin-1-yl)-N-c...)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50175839(4-((1H-imidazol-4-yl)methyl)-1-(3-phenoxypropyl)pi...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50175837(1-(4-((1H-imidazol-4-yl)methyl)piperidin-1-yl)-3-p...)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50175838(4-((1H-imidazol-4-yl)methyl)-1-(4-phenylbutyl)pipe...)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50175857(4-((1H-imidazol-4-yl)methyl)-1-(4-(4-chlorophenyl)...)
Affinity DataKi:  6nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50175832(1-(4-((1H-imidazol-4-yl)methyl)piperidin-1-yl)-4-p...)
Affinity DataKi:  9nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50175856(N-(2-(4-((1H-imidazol-4-yl)methyl)piperidin-1-yl)e...)
Affinity DataKi:  9nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50175845(N-(3-(4-((1H-imidazol-4-yl)methyl)piperidin-1-yl)p...)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50175844(4-(4-((1H-imidazol-4-yl)methyl)piperidin-1-yl)-N-(...)
Affinity DataKi:  17nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50175855(1-(4-((1H-imidazol-4-yl)methyl)piperidin-1-yl)hept...)
Affinity DataKi:  18nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50175850(4-(3-(4-((1H-imidazol-4-yl)methyl)piperidin-1-yl)p...)
Affinity DataKi:  20nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50175848(3-(4-((1H-imidazol-4-yl)methyl)piperidin-1-yl)-N-(...)
Affinity DataKi:  21nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50175826(4-((1H-imidazol-4-yl)methyl)-1-(3-(phenylsulfonyl)...)
Affinity DataKi:  25nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50175854(5-(4-((1H-imidazol-4-yl)methyl)piperidin-1-yl)-N-(...)
Affinity DataKi:  40nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50175847(4-(3-(4-((1H-imidazol-4-yl)methyl)piperidin-1-yl)p...)
Affinity DataKi:  44nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50175835(3-(4-((1H-imidazol-4-yl)methyl)piperidin-1-yl)-N-(...)
Affinity DataKi:  50nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50175841(3-(4-((1H-imidazol-4-yl)methyl)piperidin-1-yl)-N-(...)
Affinity DataKi:  60nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50175849(2-(4-((1H-imidazol-4-yl)methyl)piperidin-1-yl)-N-(...)
Affinity DataKi:  90nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50175842(4-((1H-imidazol-4-yl)methyl)-N-(4-chlorophenyl)pip...)
Affinity DataKi:  160nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50175853(2-(4-((1H-imidazol-4-yl)methyl)piperidin-1-yl)-N-(...)
Affinity DataKi:  170nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H1 receptor(Guinea pig)
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50175833(3-(4-((1H-imidazol-4-yl)methyl)piperidin-1-yl)-N-(...)
Affinity DataKi:  290nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from histamine H1 receptor in guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50175852(methyl 4-(3-(4-((1H-imidazol-4-yl)methyl)piperidin...)
Affinity DataKi:  625nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50175840(4-(4-((1H-imidazol-4-yl)methyl)piperidin-1-yl)-N-(...)
Affinity DataKi:  970nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed