Compile Data Set for Download or QSAR
Report error Found 31 Enz. Inhib. hit(s) with all data for entry = 50016733
TargetSigma non-opioid intracellular receptor 1(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50172886((S)-2-[3-(Methyl-phenethyl-amino)-propyl]-10,10a-d...)
Affinity DataIC50: 2.10nMpH: 7.5Assay Description:Inhibitory activity against opioid receptor sigma 1 in guinea pig cerebral cortex using [3H](+)-pentazocine as radio ligand at pH 7.5 for 150 min at ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Université

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataIC50: 2.10nMpH: 7.5Assay Description:Inhibitory activity against opioid receptor sigma 1 in guinea pig cerebral cortex using [3H](+)-pentazocine as radio ligand at pH 7.5 for 150 min at ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetSigma non-opioid intracellular receptor 1(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50172884((S)-2-(1-Benzyl-piperidin-4-yl)-10,10a-dihydro-5H-...)
Affinity DataIC50: 2.40nMpH: 7.5 T: 2°CAssay Description:Inhibitory activity against Opioid receptor sigma 1 in guinea pig cerebral cortex using [3H](+)-pentazocine as radio ligand at pH 7.5 for 150 min at ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50172874((S)-2-{2-[Methyl-(5-phenyl-pentyl)-amino]-ethyl}-1...)
Affinity DataIC50: 2.90nMpH: 7.5Assay Description:Inhibitory activity against opioid receptor sigma 1 in guinea pig cerebral cortex using [3H](+)-pentazocine as radio ligand at pH 7.5 for 150 min at ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50172869((S)-2-{2-[Methyl-(4-phenyl-butyl)-amino]-ethyl}-10...)
Affinity DataIC50: 3.20nMpH: 7.5Assay Description:Inhibitory activity against opioid receptor sigma 1 in guinea pig cerebral cortex using [3H](+)-pentazocine as radio ligand at pH 7.5 for 150 min at ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50172868(CHEMBL365754 | (S)-2-[3-(Benzyl-methyl-amino)-prop...)
Affinity DataIC50: 3.90nMpH: 7.5Assay Description:Inhibitory activity against opioid receptor sigma 1 in guinea pig cerebral cortex using [3H](+)-pentazocine as radio ligand at pH 7.5 for 150 min at ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50172875((S)-2-[4-(Benzyl-methyl-amino)-butyl]-10,10a-dihyd...)
Affinity DataIC50: 4.20nMpH: 7.5Assay Description:Inhibitory activity against opioid receptor sigma 1 in guinea pig cerebral cortex using [3H](+)-pentazocine as radio ligand at pH 7.5 for 150 min at ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50172881((S)-2-[2-(Benzyl-methyl-amino)-ethyl]-10,10a-dihyd...)
Affinity DataIC50: 4.5nMpH: 7.5Assay Description:Inhibitory activity against opioid receptor sigma 1 in guinea pig cerebral cortex using [3H](+)-pentazocine as radio ligand at pH 7.5 for 150 min at ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50172880((S)-2-[5-(Benzyl-methyl-amino)-pentyl]-10,10a-dihy...)
Affinity DataIC50: 5nMpH: 7.5Assay Description:Inhibitory activity against opioid receptor sigma 1 in guinea pig cerebral cortex using [3H](+)-pentazocine as radio ligand at pH 7.5 for 150 min at ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50172887((S)-2-[6-(Benzyl-methyl-amino)-hexyl]-10,10a-dihyd...)
Affinity DataIC50: 9.40nMpH: 7.5Assay Description:Inhibitory activity against opioid receptor sigma 1 in guinea pig cerebral cortex using [3H](+)-pentazocine as radio ligand at pH 7.5 for 150 min at ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50172871((S)-2-(3-Benzylamino-propyl)-10,10a-dihydro-5H-imi...)
Affinity DataIC50: 9.60nMpH: 7.5Assay Description:Inhibitory activity against opioid receptor sigma 1 in guinea pig cerebral cortex using [3H](+)-pentazocine as radio ligand at pH 7.5 for 150 min at ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50172876((S)-2-[4-(Methyl-phenethyl-amino)-butyl]-10,10a-di...)
Affinity DataIC50: 9.90nMpH: 7.5Assay Description:Inhibitory activity against opioid receptor sigma 1 in guinea pig cerebral cortex using [3H](+)-pentazocine as radio ligand at pH 7.5 for 150 min at ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50172873((S)-2-[3-(4-Phenyl-butylamino)-propyl]-10,10a-dihy...)
Affinity DataIC50: 10.5nMpH: 7.5Assay Description:Inhibitory activity against opioid receptor sigma 1 in guinea pig cerebral cortex using [3H](+)-pentazocine as radio ligand at pH 7.5 for 150 min at ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50172893((S)-2-[5-(Methyl-phenethyl-amino)-pentyl]-10,10a-d...)
Affinity DataIC50: 11.7nMpH: 7.5Assay Description:Inhibitory activity against opioid receptor sigma 1 in guinea pig cerebral cortex using [3H](+)-pentazocine as radio ligand at pH 7.5 for 150 min at ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50172867((S)-2-[2-(Methyl-phenethyl-amino)-ethyl]-10,10a-di...)
Affinity DataIC50: 12.6nMpH: 7.5Assay Description:Inhibitory activity against opioid receptor sigma 1 in guinea pig cerebral cortex using [3H](+)-pentazocine as radio ligand at pH 7.5 for 150 min at ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50172888((S)-2-{2-[Methyl-(3-phenyl-propyl)-amino]-ethyl}-1...)
Affinity DataIC50: 13.6nMpH: 7.5Assay Description:Inhibitory activity against opioid receptor sigma 1 in guinea pig cerebral cortex using [3H](+)-pentazocine as radio ligand at pH 7.5 for 150 min at ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50172877(CHEMBL371741 | CHEMBL195304 | (S)-2-(2-Piperidin-1...)
Affinity DataIC50: 16nMpH: 7.5Assay Description:Inhibitory activity against opioid receptor sigma 1 in guinea pig cerebral cortex using [3H](+)-pentazocine as radio ligand at pH 7.5 for 150 min at ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50172879((S)-2-(3-Piperidin-1-yl-propyl)-10,10a-dihydro-5H-...)
Affinity DataIC50: 21.5nMpH: 7.5Assay Description:Inhibitory activity against opioid receptor sigma 1 in guinea pig cerebral cortex using [3H](+)-pentazocine as radio ligand at pH 7.5 for 150 min at ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50172889((S)-2-[3-(4-Benzo[1,3]dioxol-5-ylmethyl-piperazin-...)
Affinity DataIC50: 23.8nMpH: 7.5Assay Description:Inhibitory activity against opioid receptor sigma 1 in guinea pig cerebral cortex using [3H](+)-pentazocine as radio ligand at pH 7.5 for 150 min at ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50172885((S)-2-[6-(Methyl-phenethyl-amino)-hexyl]-10,10a-di...)
Affinity DataIC50: 29.5nMpH: 7.5 T: 2°CAssay Description:Inhibitory activity against Opioid receptor sigma 1 in guinea pig cerebral cortex using [3H](+)-pentazocine as radio ligand at pH 7.5 for 150 min at ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50172872((S)-2-[3-(4-Benzyl-piperazin-1-yl)-propyl]-10,10a-...)
Affinity DataIC50: 32nMpH: 7.5Assay Description:Inhibitory activity against opioid receptor sigma 1 in guinea pig cerebral cortex using [3H](+)-pentazocine as radio ligand at pH 7.5 for 150 min at ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50172891((S)-2-[3-(1-Benzyl-piperidin-4-ylamino)-propyl]-10...)
Affinity DataIC50: 82.3nMpH: 7.5Assay Description:Inhibitory activity against opioid receptor sigma 1 in guinea pig cerebral cortex using [3H](+)-pentazocine as radio ligand at pH 7.5 for 150 min at ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50172896((S)-2-[2-(4-Methyl-piperazin-1-yl)-ethyl]-10,10a-d...)
Affinity DataIC50: 100nMpH: 7.5Assay Description:Inhibitory activity against opioid receptor sigma 1 in guinea pig cerebral cortex using [3H](+)-pentazocine as radio ligand at pH 7.5 for 150 min at ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50172895((S)-2-[3-(4-Methyl-piperazin-1-yl)-propyl]-10,10a-...)
Affinity DataIC50: 100nMpH: 7.5Assay Description:Inhibitory activity against opioid receptor sigma 1 in guinea pig cerebral cortex using [3H](+)-pentazocine as radio ligand at pH 7.5 for 150 min at ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50172894(2-{4-[2-((S)-1,3-Dioxo-1,5,10,10a-tetrahydro-imida...)
Affinity DataIC50: 100nMpH: 7.5Assay Description:Inhibitory activity against opioid receptor sigma 1 in guinea pig cerebral cortex using [3H](+)-pentazocine as radio ligand at pH 7.5 for 150 min at ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50172882(2-{Benzyl-[3-((S)-1,3-dioxo-1,5,10,10a-tetrahydro-...)
Affinity DataIC50: 100nMpH: 7.5 T: 2°CAssay Description:Inhibitory activity against Opioid receptor sigma 1 in guinea pig cerebral cortex using [3H](+)-pentazocine as radio ligand at pH 7.5 for 150 min at ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50172892((S)-2-[3-(Methyl-phenyl-amino)-propyl]-10,10a-dihy...)
Affinity DataIC50: 100nMpH: 7.5Assay Description:Inhibitory activity against opioid receptor sigma 1 in guinea pig cerebral cortex using [3H](+)-pentazocine as radio ligand at pH 7.5 for 150 min at ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50172883((S)-2-{3-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-prop...)
Affinity DataIC50: 100nMpH: 7.5Assay Description:Inhibitory activity against opioid receptor sigma 1 in guinea pig cerebral cortex using [3H](+)-pentazocine as radio ligand at pH 7.5 for 150 min at ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50172878((S)-2-{3-[4-(3-Dimethylamino-propyl)-piperazin-1-y...)
Affinity DataIC50: 100nMpH: 7.5Assay Description:Inhibitory activity against opioid receptor sigma 1 in guinea pig cerebral cortex using [3H](+)-pentazocine as radio ligand at pH 7.5 for 150 min at ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50172870((S)-2-{2-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-ethy...)
Affinity DataIC50: 100nMpH: 7.5Assay Description:Inhibitory activity against opioid receptor sigma 1 in guinea pig cerebral cortex using [3H](+)-pentazocine as radio ligand at pH 7.5 for 150 min at ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50172890((S)-2-{2-[4-(3-Dimethylamino-propyl)-piperazin-1-y...)
Affinity DataIC50: 1.00E+3nMpH: 7.5Assay Description:Inhibitory activity against opioid receptor sigma 1 in guinea pig cerebral cortex using [3H](+)-pentazocine as radio ligand at pH 7.5 for 150 min at ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed