Compile Data Set for Download or QSAR
Report error Found 45 Enz. Inhib. hit(s) with all data for entry = 50015750
TargetMetabotropic glutamate receptor 5(Rat)
Yale University

Curated by ChEMBL
LigandPNGBDBM50160632(3-(6-Methyl-pyridin-2-ylethynyl)-benzonitrile | 3-...)
Affinity DataIC50: 5nMAssay Description:Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Yale University

Curated by ChEMBL
LigandPNGBDBM50123005(2-(3-Methoxy-phenylethynyl)-6-methyl-pyridine | 2-...)
Affinity DataIC50: 8nMAssay Description:Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 5(Rat)
Yale University

Curated by ChEMBL
LigandPNGBDBM50160625(2-Methyl-6-(3-nitro-phenylethynyl)-pyridine | CHEM...)
Affinity DataIC50: 13nMAssay Description:Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Yale University

Curated by ChEMBL
LigandPNGBDBM50160633(2-methyl-6-[(5-phenylpyridin-3-yl)ethynyl]pyridine...)
Affinity DataIC50: 20nMAssay Description:Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Yale University

Curated by ChEMBL
LigandPNGBDBM50084137(2-Methyl-6-phenylethynyl-pyridine | CHEMBL66654 | ...)
Affinity DataIC50: 36nMAssay Description:Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Yale University

Curated by ChEMBL
LigandPNGBDBM50160634(1-[3-(6-Methyl-pyridin-2-ylethynyl)-phenyl]-ethano...)
Affinity DataIC50: 146nMAssay Description:Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Yale University

Curated by ChEMBL
LigandPNGBDBM50160635(Methanesulfonic acid 3-(6-methyl-pyridin-2-ylethyn...)
Affinity DataIC50: 180nMAssay Description:Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Yale University

Curated by ChEMBL
LigandPNGBDBM50160648(3-(6-Methyl-pyridin-2-ylethynyl)-phenylamine | CHE...)
Affinity DataIC50: 188nMAssay Description:Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Yale University

Curated by ChEMBL
LigandPNGBDBM50160627(2-{[5-(2-furyl)pyridin-3-yl]ethynyl}-6-methylpyrid...)
Affinity DataIC50: 205nMAssay Description:Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Yale University

Curated by ChEMBL
LigandPNGBDBM50160639(3-(6-Methyl-pyridin-2-ylethynyl)-benzoic acid meth...)
Affinity DataIC50: 208nMAssay Description:Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Yale University

Curated by ChEMBL
LigandPNGBDBM50160624(6-Methyl-5''-(6-methyl-pyridin-2-ylethynyl)-[2,3''...)
Affinity DataIC50: 257nMAssay Description:Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Yale University

Curated by ChEMBL
LigandPNGBDBM50160623(2-methyl-6-[(5-thien-2-ylpyridin-3-yl)ethynyl]pyri...)
Affinity DataIC50: 271nMAssay Description:Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Yale University

Curated by ChEMBL
LigandPNGBDBM50160631(2-{[5-(3-methoxyphenyl)pyridin-3-yl]ethynyl}-6-met...)
Affinity DataIC50: 282nMAssay Description:Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Yale University

Curated by ChEMBL
LigandPNGBDBM50160650(2-(3-Allyloxy-phenylethynyl)-6-methyl-pyridine | C...)
Affinity DataIC50: 290nMAssay Description:Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Yale University

Curated by ChEMBL
LigandPNGBDBM50160640(2-(3-Furan-2-yl-phenylethynyl)-6-methyl-pyridine |...)
Affinity DataIC50: 371nMAssay Description:Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Yale University

Curated by ChEMBL
LigandPNGBDBM50160641(2-(3-Cyclopropylmethoxy-phenylethynyl)-6-methyl-py...)
Affinity DataIC50: 420nMAssay Description:Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Yale University

Curated by ChEMBL
LigandPNGBDBM50160630(2-(3''-Methoxy-biphenyl-3-ylethynyl)-6-methyl-pyri...)
Affinity DataIC50: 493nMAssay Description:Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Yale University

Curated by ChEMBL
LigandPNGBDBM50160621(2-Biphenyl-3-ylethynyl-6-methyl-pyridine | CHEMBL1...)
Affinity DataIC50: 629nMAssay Description:Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Yale University

Curated by ChEMBL
LigandPNGBDBM50160622(2-Methyl-6-(3-thiophen-2-yl-phenylethynyl)-pyridin...)
Affinity DataIC50: 656nMAssay Description:Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Yale University

Curated by ChEMBL
LigandPNGBDBM50160643(Phenyl-acetic acid 3-(6-methyl-pyridin-2-ylethynyl...)
Affinity DataIC50: 740nMAssay Description:Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Yale University

Curated by ChEMBL
LigandPNGBDBM50160649(3-Phenyl-propionic acid 3-(6-methyl-pyridin-2-ylet...)
Affinity DataIC50: 890nMAssay Description:Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Yale University

Curated by ChEMBL
LigandPNGBDBM50160653(Furan-2-carboxylic acid 3-(6-methyl-pyridin-2-ylet...)
Affinity DataIC50: 1.01E+3nMAssay Description:Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Yale University

Curated by ChEMBL
LigandPNGBDBM50160620(3-Iodo-benzoic acid 3-(6-methyl-pyridin-2-ylethyny...)
Affinity DataIC50: 1.10E+3nMAssay Description:Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Yale University

Curated by ChEMBL
LigandPNGBDBM50160637(2-Methyl-6-[3-(4-phenyl-butoxy)-phenylethynyl]-pyr...)
Affinity DataIC50: 1.16E+3nMAssay Description:Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Yale University

Curated by ChEMBL
LigandPNGBDBM50160628(4-Phenyl-butyric acid 3-(6-methyl-pyridin-2-ylethy...)
Affinity DataIC50: 1.17E+3nMAssay Description:Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Yale University

Curated by ChEMBL
LigandPNGBDBM50160626(2-Methyl-6-[3-(3-phenyl-propoxy)-phenylethynyl]-py...)
Affinity DataIC50: 1.19E+3nMAssay Description:Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Yale University

Curated by ChEMBL
LigandPNGBDBM50160645(2-[3-(3-Methoxy-benzyloxy)-phenylethynyl]-6-methyl...)
Affinity DataIC50: 1.30E+3nMAssay Description:Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Yale University

Curated by ChEMBL
LigandPNGBDBM50160638(Benzoic acid 3-(6-methyl-pyridin-2-ylethynyl)-phen...)
Affinity DataIC50: 1.50E+3nMAssay Description:Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Yale University

Curated by ChEMBL
LigandPNGBDBM50160651(2-Methyl-6-(3-phenethyloxy-phenylethynyl)-pyridine...)
Affinity DataIC50: 1.59E+3nMAssay Description:Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Yale University

Curated by ChEMBL
LigandPNGBDBM50160644(3-Methoxy-benzoic acid 3-(6-methyl-pyridin-2-yleth...)
Affinity DataIC50: 1.72E+3nMAssay Description:Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Yale University

Curated by ChEMBL
LigandPNGBDBM50160636(2-(3-Benzyloxy-phenylethynyl)-6-methyl-pyridine | ...)
Affinity DataIC50: 1.84E+3nMAssay Description:Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Yale University

Curated by ChEMBL
LigandPNGBDBM50160647(2-[3-(3-Iodo-benzyloxy)-phenylethynyl]-6-methyl-py...)
Affinity DataIC50: 1.98E+3nMAssay Description:Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Yale University

Curated by ChEMBL
LigandPNGBDBM50160646(2-{3-[2-(4-Fluoro-phenyl)-ethoxy]-phenylethynyl}-6...)
Affinity DataIC50: 2.05E+3nMAssay Description:Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Yale University

Curated by ChEMBL
LigandPNGBDBM50160652([3-(6-Methyl-pyridin-2-ylethynyl)-phenoxy]-acetic ...)
Affinity DataIC50: 2.40E+3nMAssay Description:Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Yale University

Curated by ChEMBL
LigandPNGBDBM50160642(4-Bromo-butyric acid 3-(6-methyl-pyridin-2-ylethyn...)
Affinity DataIC50: 3.35E+3nMAssay Description:Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Yale University

Curated by ChEMBL
LigandPNGBDBM50160629(Toluene-4-sulfonic acid 3-(6-methyl-pyridin-2-ylet...)
Affinity DataIC50: 1.00E+4nMAssay Description:Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Yale University

Curated by ChEMBL
LigandPNGBDBM50160633(2-methyl-6-[(5-phenylpyridin-3-yl)ethynyl]pyridine...)
Affinity DataKi:  1.70nMAssay Description:In vitro binding affinity of compound towards rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Yale University

Curated by ChEMBL
LigandPNGBDBM50160627(2-{[5-(2-furyl)pyridin-3-yl]ethynyl}-6-methylpyrid...)
Affinity DataKi:  6.5nMAssay Description:In vitro binding affinity of compound towards rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Yale University

Curated by ChEMBL
LigandPNGBDBM50160624(6-Methyl-5''-(6-methyl-pyridin-2-ylethynyl)-[2,3''...)
Affinity DataKi:  13nMAssay Description:In vitro binding affinity of compound towards rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Yale University

Curated by ChEMBL
LigandPNGBDBM50160640(2-(3-Furan-2-yl-phenylethynyl)-6-methyl-pyridine |...)
Affinity DataKi:  36nMAssay Description:In vitro binding affinity of compound towards rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Yale University

Curated by ChEMBL
LigandPNGBDBM50160631(2-{[5-(3-methoxyphenyl)pyridin-3-yl]ethynyl}-6-met...)
Affinity DataKi:  74nMAssay Description:In vitro binding affinity of compound towards rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Yale University

Curated by ChEMBL
LigandPNGBDBM50160622(2-Methyl-6-(3-thiophen-2-yl-phenylethynyl)-pyridin...)
Affinity DataKi:  147nMAssay Description:In vitro binding affinity of compound towards rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Yale University

Curated by ChEMBL
LigandPNGBDBM50160623(2-methyl-6-[(5-thien-2-ylpyridin-3-yl)ethynyl]pyri...)
Affinity DataKi:  155nMAssay Description:In vitro binding affinity of compound towards rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Yale University

Curated by ChEMBL
LigandPNGBDBM50160621(2-Biphenyl-3-ylethynyl-6-methyl-pyridine | CHEMBL1...)
Affinity DataKi:  993nMAssay Description:In vitro binding affinity of compound towards rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Yale University

Curated by ChEMBL
LigandPNGBDBM50160630(2-(3''-Methoxy-biphenyl-3-ylethynyl)-6-methyl-pyri...)
Affinity DataKi:  2.36E+3nMAssay Description:In vitro binding affinity of compound towards rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed