Compile Data Set for Download or QSAR
Report error Found 25 Enz. Inhib. hit(s) with all data for entry = 50037364
Target5-hydroxytryptamine receptor 4(Guinea pig)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50155152(4-Amino-N-(1-aza-tricyclo[3.3.1.1*3,7*]dec-4-yl)-5...)
Affinity DataEC50:  262nMAssay Description:Effective concentration required towards 5-hydroxytryptamine 4 receptor in guinea pig striatum using [3H]GR-113808 as the radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Guinea pig)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50155152(4-Amino-N-(1-aza-tricyclo[3.3.1.1*3,7*]dec-4-yl)-5...)
Affinity DataEC50:  538nMAssay Description:Effective concentration required towards 5-hydroxytryptamine 4 receptor in guinea pig striatum using [3H]GR-113808 as the radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Guinea pig)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50155153(4-Amino-N-(1-aza-tricyclo[3.3.1.1*3,7*]dec-4-ylmet...)
Affinity DataEC50:  545nMAssay Description:Effective concentration required towards 5-hydroxytryptamine 4 receptor in guinea pig striatum using [3H]GR-113808 as the radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Guinea pig)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50155153(4-Amino-N-(1-aza-tricyclo[3.3.1.1*3,7*]dec-4-ylmet...)
Affinity DataEC50:  545nMAssay Description:Effective concentration required towards 5-hydroxytryptamine 4 receptor in guinea pig striatum using [3H]GR-113808 as the radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2012
Entry Details Article
PubMed
TargetSerotonin 2 (5-HT2) receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50005836(4-amino-5-chloro-N-(1-(3-(4-fluorophenoxy)propyl)-...)
Affinity DataIC50: 6.10nMAssay Description:Concentration required for inhibition of 5-hydroxytryptamine 2 receptor using [3H]ketanserin as the radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2012
Entry Details Article
PubMed
LigandPNGBDBM50005836(4-amino-5-chloro-N-(1-(3-(4-fluorophenoxy)propyl)-...)
Affinity DataIC50: 30nMAssay Description:Concentration required for inhibition of alpha-1 adrenergic receptor using [3H]prazosin as the radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2012
Entry Details Article
PubMed
LigandPNGBDBM50005836(4-amino-5-chloro-N-(1-(3-(4-fluorophenoxy)propyl)-...)
Affinity DataIC50: 4.50E+3nMAssay Description:Concentration required for inhibition of alpha-2 adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2012
Entry Details Article
PubMed
LigandPNGBDBM50181836(CHEMBL319673 | 4-amino-N-1-azatricyclo[3.3.1.0~3,7...)
Affinity DataIC50: 1.00E+4nMAssay Description:Concentration required for inhibition of beta adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2012
Entry Details Article
PubMed
TargetSerotonin 2 (5-HT2) receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50155153(4-Amino-N-(1-aza-tricyclo[3.3.1.1*3,7*]dec-4-ylmet...)
Affinity DataIC50: 1.00E+4nMAssay Description:Concentration required for inhibition of 5-hydroxytryptamine 2 receptor using [3H]ketanserin as the radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2012
Entry Details Article
PubMed
LigandPNGBDBM50181836(CHEMBL319673 | 4-amino-N-1-azatricyclo[3.3.1.0~3,7...)
Affinity DataIC50: 1.00E+4nMAssay Description:Concentration required for inhibition of alpha-1 adrenergic receptor using [3H]prazosin as the radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2012
Entry Details Article
PubMed
LigandPNGBDBM50155152(4-Amino-N-(1-aza-tricyclo[3.3.1.1*3,7*]dec-4-yl)-5...)
Affinity DataIC50: 1.00E+4nMAssay Description:Concentration required for inhibition of alpha-2 adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2012
Entry Details Article
PubMed
TargetSerotonin 2 (5-HT2) receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181836(CHEMBL319673 | 4-amino-N-1-azatricyclo[3.3.1.0~3,7...)
Affinity DataIC50: 1.00E+4nMAssay Description:Concentration required for inhibition of 5-hydroxytryptamine 2 receptor using [3H]ketanserin as the radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2012
Entry Details Article
PubMed
TargetSerotonin 2 (5-HT2) receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50155152(4-Amino-N-(1-aza-tricyclo[3.3.1.1*3,7*]dec-4-yl)-5...)
Affinity DataIC50: 1.00E+4nMAssay Description:Concentration required for inhibition of 5-hydroxytryptamine 2 receptor using [3H]ketanserin as the radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2012
Entry Details Article
PubMed
LigandPNGBDBM50155152(4-Amino-N-(1-aza-tricyclo[3.3.1.1*3,7*]dec-4-yl)-5...)
Affinity DataIC50: 1.00E+4nMAssay Description:Concentration required for inhibition of beta adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2012
Entry Details Article
PubMed
LigandPNGBDBM50155152(4-Amino-N-(1-aza-tricyclo[3.3.1.1*3,7*]dec-4-yl)-5...)
Affinity DataIC50: 1.00E+4nMAssay Description:Concentration required for inhibition of alpha-1 adrenergic receptor using [3H]prazosin as the radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2012
Entry Details Article
PubMed
LigandPNGBDBM50155153(4-Amino-N-(1-aza-tricyclo[3.3.1.1*3,7*]dec-4-ylmet...)
Affinity DataIC50: 1.00E+4nMAssay Description:Concentration required for inhibition of alpha-2 adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2012
Entry Details Article
PubMed
LigandPNGBDBM50005836(4-amino-5-chloro-N-(1-(3-(4-fluorophenoxy)propyl)-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Concentration required for inhibition of beta adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2012
Entry Details Article
PubMed
LigandPNGBDBM50181836(CHEMBL319673 | 4-amino-N-1-azatricyclo[3.3.1.0~3,7...)
Affinity DataIC50: 1.00E+4nMAssay Description:Concentration required for inhibition of alpha-2 adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2012
Entry Details Article
PubMed
LigandPNGBDBM50155153(4-Amino-N-(1-aza-tricyclo[3.3.1.1*3,7*]dec-4-ylmet...)
Affinity DataIC50: 1.00E+4nMAssay Description:Concentration required for inhibition of beta adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2012
Entry Details Article
PubMed
LigandPNGBDBM50155153(4-Amino-N-(1-aza-tricyclo[3.3.1.1*3,7*]dec-4-ylmet...)
Affinity DataIC50: 1.00E+4nMAssay Description:Concentration required for inhibition of alpha-1 adrenergic receptor using [3H]prazosin as the radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50155152(4-Amino-N-(1-aza-tricyclo[3.3.1.1*3,7*]dec-4-yl)-5...)
Affinity DataKi:  9nMAssay Description:Binding affinity for 5-hydroxytryptamine 4 receptor in rat was determined by rat tunica muscularis mucosae assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50155153(4-Amino-N-(1-aza-tricyclo[3.3.1.1*3,7*]dec-4-ylmet...)
Affinity DataKi:  51nMAssay Description:Binding affinity for 5-hydroxytryptamine 4 receptor in rat was determined by rat tunica muscularis mucosae assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50155152(4-Amino-N-(1-aza-tricyclo[3.3.1.1*3,7*]dec-4-yl)-5...)
Affinity DataKi:  57nMAssay Description:Binding affinity for 5-hydroxytryptamine 4 receptor in rat was determined by rat tunica muscularis mucosae assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A/3B(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50155153(4-Amino-N-(1-aza-tricyclo[3.3.1.1*3,7*]dec-4-ylmet...)
Affinity DataKi:  143nMAssay Description:Binding affinity towards 5-hydroxytryptamine 3 receptor using [3H]GR-65630 as the radioligand in male rat cortical tissue More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A/3B(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50155152(4-Amino-N-(1-aza-tricyclo[3.3.1.1*3,7*]dec-4-yl)-5...)
Affinity DataKi:  336nMAssay Description:Binding affinity towards 5-hydroxytryptamine 3 receptor using [3H]GR-65630 as the radioligand in male rat cortical tissue More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2012
Entry Details Article
PubMed