Compile Data Set for Download or QSAR
Report error Found 30 Enz. Inhib. hit(s) with all data for entry = 1014
LigandPNGBDBM8061(4-(2-amino-4-methyl-1,3-thiazol-5-yl)-N-(3-nitroph...)
Affinity DataKi:  4nM ΔG°:  -48.7kJ/molepH: 7.2 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
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PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Cyclacel

LigandPNGBDBM8061(4-(2-amino-4-methyl-1,3-thiazol-5-yl)-N-(3-nitroph...)
Affinity DataKi:  20nM ΔG°:  -44.7kJ/moleT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
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LigandPNGBDBM8074(4-{2-[(3-hydroxyphenyl)amino]pyrimidin-4-yl}-3,5-d...)
Affinity DataKi:  30nM ΔG°:  -43.7kJ/molepH: 7.4 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
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LigandPNGBDBM8079(4-(2,4-dimethyl-5-nitro-1H-pyrrol-3-yl)-N-(4-fluor...)
Affinity DataKi:  30nM ΔG°:  -43.7kJ/molepH: 7.4 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM8070(4-(2,4-dimethyl-1H-pyrrol-3-yl)-N-(3-nitrophenyl)p...)
Affinity DataKi:  50nM ΔG°:  -42.4kJ/molepH: 7.4 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM8072(3,5-dimethyl-4-{2-[(4-methyl-3-nitrophenyl)amino]p...)
Affinity DataKi:  50nM ΔG°:  -42.4kJ/molepH: 7.4 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM8073(4-{2-[(4-hydroxyphenyl)amino]pyrimidin-4-yl}-3,5-d...)
Affinity DataKi:  50nM ΔG°:  -42.4kJ/molepH: 7.4 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM8061(4-(2-amino-4-methyl-1,3-thiazol-5-yl)-N-(3-nitroph...)
Affinity DataKi:  70nM ΔG°:  -41.5kJ/molepH: 7.2 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM8078(4-{2-[(4-fluorophenyl)amino]pyrimidin-4-yl}-3,5-di...)
Affinity DataKi:  80nM ΔG°:  -41.2kJ/molepH: 7.4 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM8061(4-(2-amino-4-methyl-1,3-thiazol-5-yl)-N-(3-nitroph...)
Affinity DataKi:  80nM ΔG°:  -41.2kJ/molepH: 7.4 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM8076(4-{2-[(4-fluoro-3-methylphenyl)amino]pyrimidin-4-y...)
Affinity DataKi:  90nM ΔG°:  -40.9kJ/molepH: 7.4 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM8077(4-{2-[(4-fluorophenyl)amino]pyrimidin-4-yl}-3,5-di...)
Affinity DataKi:  100nM ΔG°:  -40.6kJ/molepH: 7.4 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM8079(4-(2,4-dimethyl-5-nitro-1H-pyrrol-3-yl)-N-(4-fluor...)
Affinity DataKi:  120nM ΔG°:  -40.2kJ/moleT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM8075(4-{2-[(3-hydroxy-4-methylphenyl)amino]pyrimidin-4-...)
Affinity DataKi:  130nM ΔG°:  -40.0kJ/molepH: 7.4 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM8071(3,5-dimethyl-4-{2-[(3-nitrophenyl)amino]pyrimidin-...)
Affinity DataKi:  140nM ΔG°:  -39.8kJ/molepH: 7.4 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM8074(4-{2-[(3-hydroxyphenyl)amino]pyrimidin-4-yl}-3,5-d...)
Affinity DataKi:  180nM ΔG°:  -39.1kJ/moleT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM8072(3,5-dimethyl-4-{2-[(4-methyl-3-nitrophenyl)amino]p...)
Affinity DataKi:  180nM ΔG°:  -39.1kJ/moleT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM8075(4-{2-[(3-hydroxy-4-methylphenyl)amino]pyrimidin-4-...)
Affinity DataKi:  220nM ΔG°:  -38.6kJ/moleT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM8073(4-{2-[(4-hydroxyphenyl)amino]pyrimidin-4-yl}-3,5-d...)
Affinity DataKi:  260nM ΔG°:  -38.2kJ/moleT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM8081(4-(5-bromo-2,4-dimethyl-1H-pyrrol-3-yl)-N-(4-fluor...)
Affinity DataKi:  270nM ΔG°:  -38.1kJ/molepH: 7.4 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM8076(4-{2-[(4-fluoro-3-methylphenyl)amino]pyrimidin-4-y...)
Affinity DataKi:  300nM ΔG°:  -37.9kJ/moleT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM8080(4-(5-chloro-2,4-dimethyl-1H-pyrrol-3-yl)-N-(4-fluo...)
Affinity DataKi:  360nM ΔG°:  -37.4kJ/molepH: 7.4 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM8078(4-{2-[(4-fluorophenyl)amino]pyrimidin-4-yl}-3,5-di...)
Affinity DataKi:  420nM ΔG°:  -37.0kJ/moleT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM8077(4-{2-[(4-fluorophenyl)amino]pyrimidin-4-yl}-3,5-di...)
Affinity DataKi:  900nM ΔG°:  -35.1kJ/moleT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM8071(3,5-dimethyl-4-{2-[(3-nitrophenyl)amino]pyrimidin-...)
Affinity DataKi:  960nM ΔG°:  -34.9kJ/moleT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
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PubMed
TargetProtein kinase C alpha type(Human)
Cyclacel

LigandPNGBDBM8061(4-(2-amino-4-methyl-1,3-thiazol-5-yl)-N-(3-nitroph...)
Affinity DataKi: >1.00E+3nM ΔG°: >-34.8kJ/moleT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
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PubMed
TargetCasein kinase II subunit alpha(Human)
Cyclacel

LigandPNGBDBM8061(4-(2-amino-4-methyl-1,3-thiazol-5-yl)-N-(3-nitroph...)
Affinity DataKi: >1.00E+3nM ΔG°: >-34.8kJ/moleT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM8081(4-(5-bromo-2,4-dimethyl-1H-pyrrol-3-yl)-N-(4-fluor...)
Affinity DataKi:  1.60E+3nM ΔG°:  -33.6kJ/moleT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM8080(4-(5-chloro-2,4-dimethyl-1H-pyrrol-3-yl)-N-(4-fluo...)
Affinity DataKi:  1.91E+3nM ΔG°:  -33.2kJ/moleT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM8070(4-(2,4-dimethyl-1H-pyrrol-3-yl)-N-(3-nitrophenyl)p...)
Affinity DataKi:  4.17E+3nM ΔG°:  -31.2kJ/moleT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
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PubMed