Compile Data Set for Download or QSAR
Report error Found 44 Enz. Inhib. hit(s) with all data for entry = 50014756
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50147046(5-Methylsulfanyl-4-[4-(5-propoxy-1-pyridin-2-yl-1H...)
Affinity DataIC50: 300nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50147047(5-Methylsulfanyl-4-[4-(1-phenyl-5-propyl-1H-pyrazo...)
Affinity DataKi:  60nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50147046(5-Methylsulfanyl-4-[4-(5-propoxy-1-pyridin-2-yl-1H...)
Affinity DataKi:  70nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50147059(4-[4-(5-Ethoxy-1-phenyl-1H-pyrazol-4-yl)-thiazol-2...)
Affinity DataKi:  90nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50147054(5-Methylsulfanyl-4-[4-(1-phenyl-1H-pyrazol-4-yl)-t...)
Affinity DataKi:  150nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine protease 1(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50147046(5-Methylsulfanyl-4-[4-(5-propoxy-1-pyridin-2-yl-1H...)
Affinity DataKi:  180nMAssay Description:In vitro binding affinity towards trypsin was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50147056(4-[4-(1-Methyl-3-propyl-1H-pyrazol-4-yl)-thiazol-2...)
Affinity DataKi:  190nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50147051(4-[4-(1-Methyl-5-propyl-1H-pyrazol-4-yl)-thiazol-2...)
Affinity DataKi:  330nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50099897(5-Methylsulfanyl-4-(4-p-tolyl-thiazol-2-yl)-thioph...)
Affinity DataKi:  420nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50099900(4-[4-(4-Chloro-phenyl)-thiazol-2-yl]-5-methylsulfa...)
Affinity DataKi:  436nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50099935(4-(4-Benzo[b]thiophen-3-yl-thiazol-2-yl)-5-methyls...)
Affinity DataKi:  450nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50147050(4-[4-(1-Methyl-1H-pyrazol-4-yl)-thiazol-2-yl]-5-me...)
Affinity DataKi:  460nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50099903(4-[4-(3-Methoxy-phenyl)-thiazol-2-yl]-5-methylsulf...)
Affinity DataKi:  470nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50099936(5-Methylsulfanyl-4-(4-naphthalen-2-yl-thiazol-2-yl...)
Affinity DataKi:  490nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50099937(5-Methylsulfanyl-4-(4-phenoxymethyl-thiazol-2-yl)-...)
Affinity DataKi:  520nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50147058(4-[4-(5-Cyclobutylmethoxy-1-phenyl-1H-pyrazol-4-yl...)
Affinity DataKi:  530nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50099921(5-Methylsulfanyl-4-(4-phenyl-thiazol-2-yl)-thiophe...)
Affinity DataKi:  560nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50099914(4-[4-(2,4-Dimethoxy-phenyl)-thiazol-2-yl]-5-methyl...)
Affinity DataKi:  640nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50099933(5-Methylsulfanyl-4-(4-thiophen-2-yl-thiazol-2-yl)-...)
Affinity DataKi:  700nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50099898(4-[4-(2-Methoxy-phenyl)-thiazol-2-yl]-5-methylsulf...)
Affinity DataKi:  850nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50099907(5-Methylsulfanyl-4-(4-o-tolyl-thiazol-2-yl)-thioph...)
Affinity DataKi:  850nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50099918(4-[4-(4-Chloro-3-nitro-phenyl)-thiazol-2-yl]-5-met...)
Affinity DataKi:  860nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50099917(4-[4-(4-Chloro-pyridin-3-yl)-thiazol-2-yl]-5-methy...)
Affinity DataKi:  870nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50099904(4-[4-(4-Methoxy-phenyl)-thiazol-2-yl]-5-methylsulf...)
Affinity DataKi:  900nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50099924(5-Methylsulfanyl-4-(4-m-tolyl-thiazol-2-yl)-thioph...)
Affinity DataKi:  960nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50099929(5-Methylsulfanyl-4-[4-(4-nitro-phenyl)-thiazol-2-y...)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50099920(4-[4-(2-Chloro-pyridin-3-yl)-thiazol-2-yl]-5-methy...)
Affinity DataKi:  1.02E+3nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50099909(4-(4-Benzyl-thiazol-2-yl)-5-methylsulfanyl-thiophe...)
Affinity DataKi:  1.06E+3nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50147055(4-{4-[5-(3-Methyl-butoxy)-1-phenyl-1H-pyrazol-4-yl...)
Affinity DataKi:  1.50E+3nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50109378(5-Ethyl-4-(4-phenyl-thiazol-2-yl)-thiophene-2-carb...)
Affinity DataKi:  3.00E+3nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50099916(4-[4-(2,4-Dichloro-phenyl)-thiazol-2-yl]-5-methyls...)
Affinity DataKi:  3.00E+3nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50147053(5-Methylsulfanyl-4-(5-phenyl-thiazol-2-yl)-thiophe...)
Affinity DataKi:  3.25E+3nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50099925(4-(4-Cyclohexyl-thiazol-2-yl)-5-methylsulfanyl-thi...)
Affinity DataKi:  4.70E+3nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlasminogen(Rat)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50147046(5-Methylsulfanyl-4-[4-(5-propoxy-1-pyridin-2-yl-1H...)
Affinity DataKi:  5.00E+3nMAssay Description:In vitro binding affinity towards plasmin was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCoagulation factor X(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50147046(5-Methylsulfanyl-4-[4-(5-propoxy-1-pyridin-2-yl-1H...)
Affinity DataKi:  5.00E+3nMAssay Description:In vitro binding affinity towards Coagulation factor X was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50109381(5-Methyl-4-(4-phenyl-thiazol-2-yl)-thiophene-2-car...)
Affinity DataKi:  6.00E+3nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50147057(4-(4-Phenyl-thiazol-2-yl)-5-trifluoromethyl-thioph...)
Affinity DataKi:  1.25E+4nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50109379(5-Methoxy-4-(4-phenyl-thiazol-2-yl)-thiophene-2-ca...)
Affinity DataKi:  1.44E+4nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50099899(4-(4-Biphenyl-4-yl-thiazol-2-yl)-5-methylsulfanyl-...)
Affinity DataKi:  1.54E+4nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50109374(4-(4-Phenyl-thiazol-2-yl)-thiophene-2-carboxamidin...)
Affinity DataKi: >2.00E+4nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50147052(5-Benzylsulfanyl-4-(4-phenyl-thiazol-2-yl)-thiophe...)
Affinity DataKi: >2.00E+4nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50147049(5-Ethylsulfanyl-4-(4-phenyl-thiazol-2-yl)-thiophen...)
Affinity DataKi: >2.00E+4nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50147048(5-Methanesulfonyl-4-(4-phenyl-thiazol-2-yl)-thioph...)
Affinity DataKi: >2.80E+4nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProthrombin(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50147046(5-Methylsulfanyl-4-[4-(5-propoxy-1-pyridin-2-yl-1H...)
Affinity DataKi: >5.00E+4nMAssay Description:In vitro binding affinity towards thrombin was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed