Compile Data Set for Download or QSAR
Report error Found 66 Enz. Inhib. hit(s) with all data for entry = 1010
LigandPNGBDBM8061(4-(2-amino-4-methyl-1,3-thiazol-5-yl)-N-(3-nitroph...)
Affinity DataKi:  2nM ΔG°:  -50.5kJ/moleT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM8067(N4-[4-(2,4-Dimethylthiazol-5-yl)pyrimidin-2-yl]N1,...)
Affinity DataKi:  20nM ΔG°:  -44.7kJ/moleT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM8055(4-[4-(2-Amino-4-methylthiazol-5-yl)pyrimidin-2-yla...)
Affinity DataKi:  30nM ΔG°:  -43.7kJ/moleT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM8046((4-Fluorophenyl)-[4-(2,4-dimethylthiazol-5-yl)pyri...)
Affinity DataKi:  40nM ΔG°:  -42.9kJ/molepH: 7.4 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM8061(4-(2-amino-4-methyl-1,3-thiazol-5-yl)-N-(3-nitroph...)
Affinity DataKi:  53nM ΔG°:  -42.2kJ/moleT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM8058(N,N,4-trimethyl-5-{2-[(3-nitrophenyl)amino]pyrimid...)
Affinity DataKi:  60nM ΔG°:  -41.9kJ/moleT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM8050(3-[4-(2,4-Dimethylthiazol-5-yl)pyrimidin-2-ylamino...)
Affinity DataKi:  60nM ΔG°:  -41.9kJ/molepH: 7.4 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM8054(4-[4-(4-Methyl-2-methylaminothiazol-5-yl)pyrimidin...)
Affinity DataKi:  70nM ΔG°:  -41.5kJ/moleT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM8040(4-(2,4-dimethyl-1,3-thiazol-5-yl)-N-phenylpyrimidi...)
Affinity DataKi:  80nM ΔG°:  -41.2kJ/molepH: 7.4 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM8068(2-chloro-4-N-[4-(2,4-dimethyl-1,3-thiazol-5-yl)pyr...)
Affinity DataKi:  100nM ΔG°:  -40.6kJ/moleT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM8045((3-Fluorophenyl)-[4-(2,4-dimethylthiazol-5-yl)pyri...)
Affinity DataKi:  100nM ΔG°:  -40.6kJ/molepH: 7.4 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM8056(4-(2,4-dimethyl-1,3-thiazol-5-yl)-N-(3-nitrophenyl...)
Affinity DataKi:  110nM ΔG°:  -40.4kJ/moleT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM8051(3-[4-(4-Methyl-2-methylaminothiazol-5-yl)pyrimidin...)
Affinity DataKi:  110nM ΔG°:  -40.4kJ/molepH: 7.4 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM8053(4-{[4-(2,4-dimethyl-1,3-thiazol-5-yl)pyrimidin-2-y...)
Affinity DataKi:  140nM ΔG°:  -39.8kJ/moleT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM8060([4-(2-Allylamino-4-methylthiazol-5-yl)pyrimidin-2-...)
Affinity DataKi:  160nM ΔG°:  -39.4kJ/moleT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM8050(3-[4-(2,4-Dimethylthiazol-5-yl)pyrimidin-2-ylamino...)
Affinity DataKi:  210nM ΔG°:  -38.8kJ/moleT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM8066(4-(dimethyl-1,3-thiazol-5-yl)pyrimidin-2-yl]-1-N,1...)
Affinity DataKi:  220nM ΔG°:  -38.6kJ/moleT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM8067(N4-[4-(2,4-Dimethylthiazol-5-yl)pyrimidin-2-yl]N1,...)
Affinity DataKi:  270nM ΔG°:  -38.1kJ/moleT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM8049(4-(2,4-dimethyl-1,3-thiazol-5-yl)-N-[4-(trifluorom...)
Affinity DataKi:  290nM ΔG°:  -37.9kJ/molepH: 7.4 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM8065(3-[4-(2,4-Dimethylthiazol-5-yl)pyrimidin-2-ylamino...)
Affinity DataKi:  300nM ΔG°:  -37.9kJ/moleT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM8053(4-{[4-(2,4-dimethyl-1,3-thiazol-5-yl)pyrimidin-2-y...)
Affinity DataKi:  320nM ΔG°:  -37.7kJ/moleT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM8054(4-[4-(4-Methyl-2-methylaminothiazol-5-yl)pyrimidin...)
Affinity DataKi:  320nM ΔG°:  -37.7kJ/moleT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM8055(4-[4-(2-Amino-4-methylthiazol-5-yl)pyrimidin-2-yla...)
Affinity DataKi:  320nM ΔG°:  -37.7kJ/moleT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM8051(3-[4-(4-Methyl-2-methylaminothiazol-5-yl)pyrimidin...)
Affinity DataKi:  370nM ΔG°:  -37.3kJ/moleT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM8064(1-N-[4-(2,4-dimethyl-1,3-thiazol-5-yl)pyrimidin-2-...)
Affinity DataKi:  400nM ΔG°:  -37.1kJ/moleT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM8065(3-[4-(2,4-Dimethylthiazol-5-yl)pyrimidin-2-ylamino...)
Affinity DataKi:  480nM ΔG°:  -36.7kJ/moleT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM8042((3-Chlorophenyl)-[4-(2,4-dimethylthiazol-5-yl)pyri...)
Affinity DataKi:  670nM ΔG°:  -35.8kJ/molepH: 7.4 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM8069(4-N-[4-(2-amino-4-methyl-1,3-thiazol-5-yl)pyrimidi...)
Affinity DataKi:  700nM ΔG°:  -35.7kJ/moleT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM8059([4-(4-Methyl-2-methylaminothiazol-5-yl)pyrimidin-2...)
Affinity DataKi:  800nM ΔG°:  -35.4kJ/moleT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM8069(4-N-[4-(2-amino-4-methyl-1,3-thiazol-5-yl)pyrimidi...)
Affinity DataKi:  900nM ΔG°:  -35.1kJ/moleT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM8045((3-Fluorophenyl)-[4-(2,4-dimethylthiazol-5-yl)pyri...)
Affinity DataKi:  900nM ΔG°:  -35.1kJ/moleT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM8066(4-(dimethyl-1,3-thiazol-5-yl)pyrimidin-2-yl]-1-N,1...)
Affinity DataKi:  960nM ΔG°:  -34.9kJ/moleT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM8068(2-chloro-4-N-[4-(2,4-dimethyl-1,3-thiazol-5-yl)pyr...)
Affinity DataKi:  1.00E+3nM ΔG°:  -34.8kJ/moleT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM8044((2-Fluorophenyl)-[4-(2,4-dimethylthiazol-5-yl)pyri...)
Affinity DataKi:  1.20E+3nM ΔG°:  -34.4kJ/moleT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM8044((2-Fluorophenyl)-[4-(2,4-dimethylthiazol-5-yl)pyri...)
Affinity DataKi:  1.20E+3nM ΔG°:  -34.4kJ/molepH: 7.4 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM8059([4-(4-Methyl-2-methylaminothiazol-5-yl)pyrimidin-2...)
Affinity DataKi:  1.60E+3nM ΔG°:  -33.6kJ/moleT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM8043((4-chlorophenyl)-[4-(2,4-dimethylthiazol-5-yl)pyri...)
Affinity DataKi:  2.50E+3nM ΔG°:  -32.5kJ/molepH: 7.4 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM8040(4-(2,4-dimethyl-1,3-thiazol-5-yl)-N-phenylpyrimidi...)
Affinity DataKi:  2.60E+3nM ΔG°:  -32.4kJ/moleT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM8063(4-(2,4-dimethyl-1,3-thiazol-5-yl)-N-(4-nitrophenyl...)
Affinity DataKi:  4.10E+3nM ΔG°:  -31.3kJ/moleT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM8058(N,N,4-trimethyl-5-{2-[(3-nitrophenyl)amino]pyrimid...)
Affinity DataKi:  5.30E+3nM ΔG°:  -30.6kJ/moleT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM8037(4-(2,4-dimethyl-1,3-thiazol-5-yl)pyrimidin-2-amine...)
Affinity DataKi:  6.50E+3nM ΔG°:  -30.1kJ/molepH: 7.4 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM8060([4-(2-Allylamino-4-methylthiazol-5-yl)pyrimidin-2-...)
Affinity DataKi:  7.10E+3nM ΔG°:  -29.9kJ/moleT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM8042((3-Chlorophenyl)-[4-(2,4-dimethylthiazol-5-yl)pyri...)
Affinity DataKi:  9.40E+3nM ΔG°:  -29.2kJ/moleT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM8052(3-[4-(2-Ethylamino-4-methylthiazol-5-yl)pyrimidin-...)
Affinity DataKi: >1.00E+4nM ΔG°: >-29.0kJ/molepH: 7.4 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM8064(1-N-[4-(2,4-dimethyl-1,3-thiazol-5-yl)pyrimidin-2-...)
Affinity DataKi:  1.06E+4nM ΔG°:  -28.9kJ/moleT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM8037(4-(2,4-dimethyl-1,3-thiazol-5-yl)pyrimidin-2-amine...)
Affinity DataKi:  1.60E+4nM ΔG°:  -27.8kJ/moleT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM8038(4-(2,4-dimethyl-1,3-thiazol-5-yl)-N-methylpyrimidi...)
Affinity DataKi: >2.00E+4nM ΔG°: >-27.3kJ/moleT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM8038(4-(2,4-dimethyl-1,3-thiazol-5-yl)-N-methylpyrimidi...)
Affinity DataKi: >2.00E+4nM ΔG°: >-27.3kJ/molepH: 7.4 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM8039([4-(2,4-Dimethylthiazol-5-yl)-pyrimidin-2-yl]dimet...)
Affinity DataKi: >2.00E+4nM ΔG°: >-27.3kJ/molepH: 7.4 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM8041(N-(2-chlorophenyl)-4-(2,4-dimethyl-1,3-thiazol-5-y...)
Affinity DataKi: >2.00E+4nM ΔG°: >-27.3kJ/molepH: 7.4 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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