Compile Data Set for Download or QSAR
Report error Found 142 Enz. Inhib. hit(s) with all data for entry = 50037290
TargetMu-type opioid receptor(Guinea pig)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM21015([tyrosyl-3,5-3H(N)]-D-Ala2-Mephe4-glyol5-enkephali...)
Affinity DataEC50:  414nMAssay Description:Agonistic activity towards Opioid receptor mu 1 was determined in [35S]GTP-gamma-S, binding assay in guinea pig caudateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50140909(6-(3,4-dichlorophenyl)-19-methyl-(2R,10R)-11-oxa-8...)
Affinity DataEC50:  1.31E+3nMAssay Description:Agonistic activity towards Opioid receptor mu 1 was determined in [35S]GTP-gamma-S, binding assay in guinea pig caudate; g = not active as an agonistMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50140903(19-methyl-6-phenyl-(2S,10R)-11-oxa-8,19-diazahexac...)
Affinity DataEC50:  660nMAssay Description:Agonistic activity towards Opioid receptor mu 1 was determined in [35S]GTP-gamma-S, binding assay in guinea pig caudateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50140899(19-methyl-(2S,10R)-11-oxa-8,19-diazahexacyclo[10.9...)
Affinity DataEC50:  3.00E+3nMAssay Description:Agonistic activity towards Opioid receptor mu 1 was determined in [35S]GTP-gamma-S, binding assay in guinea pig caudateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50140910(19-methyl-(2R,10R)-11-oxa-8,19-diazahexacyclo[10.9...)
Affinity DataEC50:  3.00E+3nMAssay Description:Agonistic activity towards Opioid receptor mu 1 was determined in [35S]GTP-gamma-S, binding assay in guinea pig caudateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50140901(6-(4-chlorophenyl)-19-methyl-(2R,10R)-11-oxa-8,19-...)
Affinity DataEC50:  900nMAssay Description:Agonistic activity towards Opioid receptor mu 1 was determined in [35S]GTP-gamma-S, binding assay in guinea pig caudate; g = not active as an agonistMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50140900(6-(2,4-dichlorophenyl)-19-methyl-(2R,10R)-11-oxa-8...)
Affinity DataEC50:  225nMAssay Description:Agonistic activity towards Opioid receptor mu 1 was determined in [35S]GTP-gamma-S, binding assay in guinea pig caudate; g = not active as an agonistMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDelta-type opioid receptor(Human)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50039029(CHEMBL13470 | 3-[(4-Allyl-2,5-dimethyl-piperazin-1...)
Affinity DataEC50:  760nMAssay Description:Agonistic activity towards opioid receptor delta 1 was determined in [35S]GTP-gamma-S, binding assay in guinea pig caudateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50140905(19-methyl-6-phenyl-(2R,10R)-11-oxa-8,19-diazahexac...)
Affinity DataEC50:  1.03E+3nMAssay Description:Antagonism of compound towards Opioid receptor mu 1 was determined using PL-017 in guinea pig ileum (GPI) smooth muscle contraction assays; d = agoni...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50140898(6-(4-bromophenyl)-19-methyl-(2R,10R)-11-oxa-8,19-d...)
Affinity DataEC50:  3.22E+3nMAssay Description:Agonistic activity towards Opioid receptor mu 1 was determined in [35S]GTP-gamma-S, binding assay in guinea pig caudate; g = not active as an agonistMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDelta-type opioid receptor(Mouse)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50001683(CHEMBL294616 | 13-[2-Amino-3-(4-hydroxy-phenyl)-pr...)
Affinity DataIC50: 5.80nMAssay Description:Inhibitory concentration required for 50 percent inhibition of opioid receptor delta 1 induced contractions in mouse vas deferens (MVD) smooth muscle...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDelta-type opioid receptor(Mouse)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50140905(19-methyl-6-phenyl-(2R,10R)-11-oxa-8,19-diazahexac...)
Affinity DataIC50: 48nMAssay Description:Inhibitory concentration required for 50 percent inhibition of opioid receptor delta 1 induced contractions in mouse vas deferens (MVD) smooth muscle...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDelta-type opioid receptor(Human)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50140898(6-(4-bromophenyl)-19-methyl-(2R,10R)-11-oxa-8,19-d...)
Affinity DataIC50: 55nMAssay Description:Inhibitory concentration required for 50% inhibition of antagonism towards opioid receptor delta 1 in [35S]GTP-gamma-S, binding assay in guinea pig c...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50140906(1-[2-[1-[2-amino-3-(4-hydroxyphenyl)-(2S)-propanoy...)
Affinity DataIC50: 59nMAssay Description:Inhibitory concentration for inhibition of Opioid receptor mu 1 induced contractions in guinea pig ileum (GPI) smooth muscle assaysMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50140910(19-methyl-(2R,10R)-11-oxa-8,19-diazahexacyclo[10.9...)
Affinity DataIC50: 68nMAssay Description:Inhibitory concentration for inhibition of Opioid receptor mu 1 induced contractions in guinea pig ileum (GPI) smooth muscle assaysMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDelta-type opioid receptor(Human)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50140909(6-(3,4-dichlorophenyl)-19-methyl-(2R,10R)-11-oxa-8...)
Affinity DataIC50: 74nMAssay Description:Inhibitory concentration required for 50% inhibition of antagonism towards opioid receptor delta 1 in [35S]GTP-gamma-S, binding assay in guinea pig c...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50140905(19-methyl-6-phenyl-(2R,10R)-11-oxa-8,19-diazahexac...)
Affinity DataIC50: 99nMAssay Description:Inhibitory concentration for inhibition of Opioid receptor mu 1 induced contractions in guinea pig ileum (GPI) smooth muscle assaysMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50140913(6-(4-chlorophenyl)-19-cyclopropylmethyl-(2R,10R)-1...)
Affinity DataIC50: 109nMAssay Description:Inhibitory concentration for inhibition of Opioid receptor mu 1 induced contractions in guinea pig ileum (GPI) smooth muscle assaysMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDelta-type opioid receptor(Mouse)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50140910(19-methyl-(2R,10R)-11-oxa-8,19-diazahexacyclo[10.9...)
Affinity DataIC50: 152nMAssay Description:Inhibitory concentration required for 50 percent inhibition of opioid receptor delta 1 induced contractions in mouse vas deferens (MVD) smooth muscle...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50080467(5'-(Chlorophenyl)-17-(cyclopropylmethyl) -6,7-dide...)
Affinity DataIC50: 163nMAssay Description:Inhibitory concentration for inhibition of Opioid receptor mu 1 induced contractions in guinea pig ileum (GPI) smooth muscle assaysMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50140901(6-(4-chlorophenyl)-19-methyl-(2R,10R)-11-oxa-8,19-...)
Affinity DataIC50: 177nMAssay Description:Inhibitory concentration for inhibition of Opioid receptor mu 1 induced contractions in guinea pig ileum (GPI) smooth muscle assaysMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50140903(19-methyl-6-phenyl-(2S,10R)-11-oxa-8,19-diazahexac...)
Affinity DataIC50: 211nMAssay Description:Inhibitory concentration for inhibition of Opioid receptor mu 1 induced contractions in guinea pig ileum (GPI) smooth muscle assaysMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDelta-type opioid receptor(Mouse)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50140903(19-methyl-6-phenyl-(2S,10R)-11-oxa-8,19-diazahexac...)
Affinity DataIC50: 213nMAssay Description:Inhibitory concentration required for 50 percent inhibition of opioid receptor delta 1 induced contractions in mouse vas deferens (MVD) smooth muscle...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDelta-type opioid receptor(Mouse)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50140906(1-[2-[1-[2-amino-3-(4-hydroxyphenyl)-(2S)-propanoy...)
Affinity DataIC50: 243nMAssay Description:Inhibitory concentration required for 50 percent inhibition of opioid receptor delta 1 induced contractions in mouse vas deferens (MVD) smooth muscle...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50140909(6-(3,4-dichlorophenyl)-19-methyl-(2R,10R)-11-oxa-8...)
Affinity DataIC50: 447nMAssay Description:Inhibitory concentration for inhibition of Opioid receptor mu 1 induced contractions in guinea pig ileum (GPI) smooth muscle assaysMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDelta-type opioid receptor(Mouse)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50140909(6-(3,4-dichlorophenyl)-19-methyl-(2R,10R)-11-oxa-8...)
Affinity DataIC50: 489nMAssay Description:Inhibitory concentration required for 50 percent inhibition of opioid receptor delta 1 induced contractions in mouse vas deferens (MVD) smooth muscle...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50140899(19-methyl-(2S,10R)-11-oxa-8,19-diazahexacyclo[10.9...)
Affinity DataIC50: 523nMAssay Description:Inhibitory concentration for inhibition of Opioid receptor mu 1 induced contractions in guinea pig ileum (GPI) smooth muscle assaysMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDelta-type opioid receptor(Mouse)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50140901(6-(4-chlorophenyl)-19-methyl-(2R,10R)-11-oxa-8,19-...)
Affinity DataIC50: 565nMAssay Description:Inhibitory concentration required for 50 percent inhibition of opioid receptor delta 1 induced contractions in mouse vas deferens (MVD) smooth muscle...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50140898(6-(4-bromophenyl)-19-methyl-(2R,10R)-11-oxa-8,19-d...)
Affinity DataIC50: 666nMAssay Description:Inhibitory concentration for inhibition of Opioid receptor mu 1 induced contractions in guinea pig ileum (GPI) smooth muscle assaysMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50140900(6-(2,4-dichlorophenyl)-19-methyl-(2R,10R)-11-oxa-8...)
Affinity DataIC50: 724nMAssay Description:Inhibitory concentration for inhibition of Opioid receptor mu 1 induced contractions in guinea pig ileum (GPI) smooth muscle assaysMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDelta-type opioid receptor(Human)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50140903(19-methyl-6-phenyl-(2S,10R)-11-oxa-8,19-diazahexac...)
Affinity DataIC50: 920nMAssay Description:Inhibitory concentration required for 50% inhibition of antagonism towards opioid receptor delta 1 in [35S]GTP-gamma-S, binding assay in guinea pig c...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50001683(CHEMBL294616 | 13-[2-Amino-3-(4-hydroxy-phenyl)-pr...)
Affinity DataIC50: 1.16E+4nMAssay Description:Inhibitory concentration for inhibition of Opioid receptor mu 1 induced contractions in guinea pig ileum (GPI) smooth muscle assaysMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDelta-type opioid receptor(Human)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM21864(NALTRINDOLE | (8R)-7-(cyclopropylmethyl)-5,6,7,8,1...)
Affinity DataKi:  0.0620nMAssay Description:Apparent antagonist activity determined by measuring the ability to inhibit stimulation of [35S]GTP-gamma-S, binding to opioid receptor delta 1 in gu...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDelta-type opioid receptor(Human)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50080467(5'-(Chlorophenyl)-17-(cyclopropylmethyl) -6,7-dide...)
Affinity DataKi:  0.180nMAssay Description:Apparent antagonist activity determined by measuring the ability to inhibit stimulation of [35S]GTP-gamma-S, binding to opioid receptor delta 1 in gu...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDelta-type opioid receptor(Rat)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50123273(19-cyclopropylmethyl-11-oxa-8,19-diazahexacyclo[10...)
Affinity DataKi:  0.780nMAssay Description:Binding affinity at opioid receptor delta 1 by displacement of [3H]DADLE in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDelta-type opioid receptor(Rat)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50080459(17-(Cyclopropyl-methyl) -6, 7-didehydro-3,14-dihyd...)
Affinity DataKi:  0.870nMAssay Description:Binding affinity at opioid receptor delta 1 by displacement of [3H]DADLE in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDelta-type opioid receptor(Human)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50140900(6-(2,4-dichlorophenyl)-19-methyl-(2R,10R)-11-oxa-8...)
Affinity DataKi:  1.10nMAssay Description:Apparent antagonist activity determined by measuring the ability to inhibit stimulation of [35S]GTP-gamma-S, binding to opioid receptor delta 1 in gu...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDelta-type opioid receptor(Rat)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50140900(6-(2,4-dichlorophenyl)-19-methyl-(2R,10R)-11-oxa-8...)
Affinity DataKi:  1.10nMAssay Description:Binding affinity at opioid receptor delta 1 by displacement of [3H]DADLE in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMu-type opioid receptor(Rat)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50123273(19-cyclopropylmethyl-11-oxa-8,19-diazahexacyclo[10...)
Affinity DataKi:  1.5nMAssay Description:Binding affinity at Opioid receptor mu 1 by displacement of [3H]DAMGO in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDelta-type opioid receptor(Human)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50140913(6-(4-chlorophenyl)-19-cyclopropylmethyl-(2R,10R)-1...)
Affinity DataKi:  1.60nMAssay Description:Apparent antagonist activity determined by measuring the ability to inhibit stimulation of [35S]GTP-gamma-S, binding to opioid receptor delta 1 in gu...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDelta-type opioid receptor(Rat)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM21864(NALTRINDOLE | (8R)-7-(cyclopropylmethyl)-5,6,7,8,1...)
Affinity DataKi:  1.60nMAssay Description:Binding affinity at opioid receptor delta 1 by displacement of [3H]DADLE in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDelta-type opioid receptor(Rat)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50140905(19-methyl-6-phenyl-(2R,10R)-11-oxa-8,19-diazahexac...)
Affinity DataKi:  1.90nMAssay Description:Binding affinity at opioid receptor delta 1 by displacement of [3H]DADLE in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM60212(SMR000058767 | NALTREXONE HYDROCHLORIDE | MLS00006...)
Affinity DataKi:  2.20nMAssay Description:Binding affinity at Opioid receptor kappa 1 by displacement of [3H]U-69593 in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDelta-type opioid receptor(Rat)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50080467(5'-(Chlorophenyl)-17-(cyclopropylmethyl) -6,7-dide...)
Affinity DataKi:  2.20nMAssay Description:Binding affinity at opioid receptor delta 1 by displacement of [3H]DADLE in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMu-type opioid receptor(Rat)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM60212(SMR000058767 | NALTREXONE HYDROCHLORIDE | MLS00006...)
Affinity DataKi:  2.40nMAssay Description:Binding affinity at Opioid receptor mu 1 by displacement of [3H]DAMGO in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDelta-type opioid receptor(Rat)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50140913(6-(4-chlorophenyl)-19-cyclopropylmethyl-(2R,10R)-1...)
Affinity DataKi:  2.60nMAssay Description:Binding affinity at opioid receptor delta 1 by displacement of [3H]DADLE in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDelta-type opioid receptor(Rat)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50140903(19-methyl-6-phenyl-(2S,10R)-11-oxa-8,19-diazahexac...)
Affinity DataKi:  2.90nMAssay Description:Binding affinity at opioid receptor delta 1 by displacement of [3H]DADLE in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM21864(NALTRINDOLE | (8R)-7-(cyclopropylmethyl)-5,6,7,8,1...)
Affinity DataKi:  3.20nMAssay Description:Apparent binding affinity of compound was determined by antagonism towards Opioid receptor mu 1 in [35S]GTP-gamma-S, binding assay in guinea pig caud...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDelta-type opioid receptor(Rat)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50140909(6-(3,4-dichlorophenyl)-19-methyl-(2R,10R)-11-oxa-8...)
Affinity DataKi:  3.70nMAssay Description:Binding affinity at opioid receptor delta 1 by displacement of [3H]DADLE in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDelta-type opioid receptor(Rat)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50140917(6-(4-chlorophenyl)-19-methyl-(2S,10R)-11-oxa-8,19-...)
Affinity DataKi:  3.90nMAssay Description:Binding affinity at opioid receptor delta 1 by displacement of [3H]DADLE in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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