Compile Data Set for Download or QSAR
Report error Found 79 Enz. Inhib. hit(s) with all data for entry = 50013626
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50118975(4-(4-Methoxy-benzenesulfonyl)-1-(thiophene-2-carbo...)
Affinity DataIC50: 1nMAssay Description:In vitro inhibition of matrix metalloprotease-13.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50132620((2R,3S)-4-Acetyl-1-[4-(4-fluoro-benzyloxy)-benzene...)
Affinity DataIC50: 3nMAssay Description:In vitro inhibition of matrix metalloprotease-13.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50132632((2R,3S)-4-Acetyl-3-methyl-1-[4-(2-methyl-benzyloxy...)
Affinity DataIC50: 3nMAssay Description:In vitro inhibition of matrix metalloprotease-13.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50132628((2R,3S)-4-Methanesulfonyl-3-methyl-1-[4-(2-methyl-...)
Affinity DataIC50: 4nMAssay Description:In vitro inhibition of matrix metalloprotease-13.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50132638((2S,3R)-2-Methyl-4-[4-(2-methyl-benzyloxy)-benzene...)
Affinity DataIC50: 4nMAssay Description:In vitro inhibition of matrix metalloprotease-13.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50132625((2S,3R)-3-Hydroxycarbamoyl-2-methyl-4-[4-(2-methyl...)
Affinity DataIC50: 4nMAssay Description:In vitro inhibition of matrix metalloprotease-13.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50132634((2R,3S)-4-Acetyl-3-methyl-1-[4-(2-methyl-pyridin-3...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant tumor necrosis factor-alpha converting enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50132628((2R,3S)-4-Methanesulfonyl-3-methyl-1-[4-(2-methyl-...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human recombinant tumor necrosis factor-alpha converting enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50132636((2R,3S)-4-Acetyl-1-[4-(3,5-difluoro-benzyloxy)-ben...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human recombinant tumor necrosis factor-alpha converting enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50132621((2S,3R)-3-Hydroxycarbamoyl-2-methyl-4-[4-(2-methyl...)
Affinity DataIC50: 6nMAssay Description:In vitro inhibition of matrix metalloprotease-13.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50132632((2R,3S)-4-Acetyl-3-methyl-1-[4-(2-methyl-benzyloxy...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human recombinant tumor necrosis factor-alpha converting enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50132620((2R,3S)-4-Acetyl-1-[4-(4-fluoro-benzyloxy)-benzene...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human recombinant tumor necrosis factor-alpha converting enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50132626((2R,3S)-4-Acetyl-1-[4-(2-ethyl-benzyloxy)-benzenes...)
Affinity DataIC50: 7nMAssay Description:Inhibition of human recombinant tumor necrosis factor-alpha converting enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50132623((2R,3S)-4-Acetyl-1-[4-(5-fluoro-2-methyl-benzyloxy...)
Affinity DataIC50: 7nMAssay Description:Inhibition of human recombinant tumor necrosis factor-alpha converting enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50132624((S)-3-(Formyl-hydroxy-amino)-2-isobutyl-4-methyl-p...)
Affinity DataIC50: 7nMAssay Description:In vitro inhibition of matrix metalloprotease-13.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50132623((2R,3S)-4-Acetyl-1-[4-(5-fluoro-2-methyl-benzyloxy...)
Affinity DataIC50: 7nMAssay Description:In vitro inhibition of matrix metalloprotease-13.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50132634((2R,3S)-4-Acetyl-3-methyl-1-[4-(2-methyl-pyridin-3...)
Affinity DataIC50: 8nMAssay Description:In vitro inhibition of matrix metalloprotease-13.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50113038((2R,4S)-1-(4-Benzyloxy-benzenesulfonyl)-4-hydroxy-...)
Affinity DataIC50: 9nMAssay Description:Inhibition of human recombinant tumor necrosis factor-alpha converting enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50132635((2R,3S)-4-Acetyl-3-methyl-1-[4-(2-trifluoromethyl-...)
Affinity DataIC50: 11nMAssay Description:Inhibition of human recombinant tumor necrosis factor-alpha converting enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50132633((2R,3S)-1-(4-Benzyloxy-benzenesulfonyl)-3-methyl-p...)
Affinity DataIC50: 11nMAssay Description:In vitro inhibition of matrix metalloprotease-13.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50111693(5-Bromo-N-hydroxy-3-methyl-2-[methyl-(4-prop-2-yny...)
Affinity DataIC50: 11nMAssay Description:Inhibition of human recombinant tumor necrosis factor-alpha converting enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50118975(4-(4-Methoxy-benzenesulfonyl)-1-(thiophene-2-carbo...)
Affinity DataIC50: 13nMAssay Description:Inhibition of human recombinant tumor necrosis factor-alpha converting enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50132625((2S,3R)-3-Hydroxycarbamoyl-2-methyl-4-[4-(2-methyl...)
Affinity DataIC50: 14nMAssay Description:Inhibition of human recombinant tumor necrosis factor-alpha converting enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50132627((2R,3S)-4-Acetyl-3-methyl-1-[4-(quinolin-4-ylmetho...)
Affinity DataIC50: 17nMAssay Description:In vitro inhibition of matrix metalloprotease-13.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50132631((2R,3S)-3-Methyl-1-[4-(2-methyl-benzyloxy)-benzene...)
Affinity DataIC50: 19nMAssay Description:Inhibition of human recombinant tumor necrosis factor-alpha converting enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50132624((S)-3-(Formyl-hydroxy-amino)-2-isobutyl-4-methyl-p...)
Affinity DataIC50: 19nMAssay Description:In vitro inhibition of matrix metalloprotease-1.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50132631((2R,3S)-3-Methyl-1-[4-(2-methyl-benzyloxy)-benzene...)
Affinity DataIC50: 19nMAssay Description:In vitro inhibition of matrix metalloprotease-13.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50118975(4-(4-Methoxy-benzenesulfonyl)-1-(thiophene-2-carbo...)
Affinity DataIC50: 20nMAssay Description:In vitro inhibition of matrix metalloprotease-1.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50132636((2R,3S)-4-Acetyl-1-[4-(3,5-difluoro-benzyloxy)-ben...)
Affinity DataIC50: 20nMAssay Description:In vitro inhibition of matrix metalloprotease-13.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50132633((2R,3S)-1-(4-Benzyloxy-benzenesulfonyl)-3-methyl-p...)
Affinity DataIC50: 25nMAssay Description:Inhibition of human recombinant tumor necrosis factor-alpha converting enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50132637((2S,3R)-2-Methyl-4-[4-(2-methyl-benzyloxy)-benzene...)
Affinity DataIC50: 26nMAssay Description:Inhibition of human recombinant tumor necrosis factor-alpha converting enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50132621((2S,3R)-3-Hydroxycarbamoyl-2-methyl-4-[4-(2-methyl...)
Affinity DataIC50: 28nMAssay Description:Inhibition of human recombinant tumor necrosis factor-alpha converting enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50132630((2R,3S)-3,4-Dimethyl-1-[4-(2-methyl-benzyloxy)-ben...)
Affinity DataIC50: 31nMAssay Description:Inhibition of human recombinant tumor necrosis factor-alpha converting enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50132622((2R,3S)-3-Methyl-1-[4-(2-methyl-benzyloxy)-benzene...)
Affinity DataIC50: 32nMAssay Description:Inhibition of human recombinant tumor necrosis factor-alpha converting enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50132638((2S,3R)-2-Methyl-4-[4-(2-methyl-benzyloxy)-benzene...)
Affinity DataIC50: 34nMAssay Description:Inhibition of human recombinant tumor necrosis factor-alpha converting enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50132626((2R,3S)-4-Acetyl-1-[4-(2-ethyl-benzyloxy)-benzenes...)
Affinity DataIC50: 40nMAssay Description:In vitro inhibition of matrix metalloprotease-13.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50132624((S)-3-(Formyl-hydroxy-amino)-2-isobutyl-4-methyl-p...)
Affinity DataIC50: 40nMAssay Description:Inhibition of human recombinant tumor necrosis factor-alpha converting enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50111693(5-Bromo-N-hydroxy-3-methyl-2-[methyl-(4-prop-2-yny...)
Affinity DataIC50: 52nMAssay Description:In vitro inhibition of matrix metalloprotease-1.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50132619((2R,3S)-4-Benzyl-3-methyl-1-[4-(2-methyl-benzyloxy...)
Affinity DataIC50: 68nMAssay Description:Inhibition of human recombinant tumor necrosis factor-alpha converting enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50132629((2R,3S)-4-Acetyl-1-[4-(isoquinolin-4-ylmethoxy)-be...)
Affinity DataIC50: 98nMAssay Description:In vitro inhibition of matrix metalloprotease-13.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50111693(5-Bromo-N-hydroxy-3-methyl-2-[methyl-(4-prop-2-yny...)
Affinity DataIC50: 113nMAssay Description:In vitro inhibition of matrix metalloprotease-13.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50132635((2R,3S)-4-Acetyl-3-methyl-1-[4-(2-trifluoromethyl-...)
Affinity DataIC50: 127nMAssay Description:In vitro inhibition of matrix metalloprotease-13.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50132627((2R,3S)-4-Acetyl-3-methyl-1-[4-(quinolin-4-ylmetho...)
Affinity DataIC50: 300nMAssay Description:Inhibition of human recombinant tumor necrosis factor-alpha converting enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50132629((2R,3S)-4-Acetyl-1-[4-(isoquinolin-4-ylmethoxy)-be...)
Affinity DataIC50: 400nMAssay Description:Inhibition of human recombinant tumor necrosis factor-alpha converting enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50132626((2R,3S)-4-Acetyl-1-[4-(2-ethyl-benzyloxy)-benzenes...)
Affinity DataIC50: 600nMAssay Description:Inhibition of human recombinant tumor necrosis factor-alpha converting enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50132634((2R,3S)-4-Acetyl-3-methyl-1-[4-(2-methyl-pyridin-3...)
Affinity DataIC50: 800nMAssay Description:Inhibition of Tumor necrosis factor-alpha (TNF-alpha) release in human whole bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50132627((2R,3S)-4-Acetyl-3-methyl-1-[4-(quinolin-4-ylmetho...)
Affinity DataIC50: 830nMAssay Description:In vitro inhibition of matrix metalloprotease-1.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50132628((2R,3S)-4-Methanesulfonyl-3-methyl-1-[4-(2-methyl-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of Tumor necrosis factor-alpha (TNF-alpha) release in human whole bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50132632((2R,3S)-4-Acetyl-3-methyl-1-[4-(2-methyl-benzyloxy...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of Tumor necrosis factor-alpha (TNF-alpha) release in human whole bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50132623((2R,3S)-4-Acetyl-1-[4-(5-fluoro-2-methyl-benzyloxy...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of Tumor necrosis factor-alpha (TNF-alpha) release in human whole bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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