Compile Data Set for Download or QSAR
Report error Found 45 Enz. Inhib. hit(s) with all data for entry = 50037038
TargetSodium/hydrogen exchanger 1(Rat)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50115243((S)-N-[7-(5-fluoro-2-methylphenyl)-4-methyl-(7S)-5...)
Affinity DataIC50: 14nMAssay Description:In vitro inhibition of acid induced swelling in rat platelets by 50% as a measure of NHE-1 inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Rat)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50115239((S)-N-[7-(2,5-dichloro-3-thienyl)-4-methyl-(7S)-5,...)
Affinity DataIC50: 17nMAssay Description:In vitro inhibition of acid induced swelling in rat platelets by 50% as a measure of NHE-1 inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Rat)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50115248(N-[7-(3-chloro-2-thienyl)-4-methyl-5,6,7,8-tetrahy...)
Affinity DataIC50: 19nMAssay Description:In vitro inhibition of acid induced swelling in rat platelets by 50% as a measure of NHE-1 inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Rat)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50115246(N-[7-(2-chloro-5-fluorophenyl)-4-methyl-5,6,7,8-te...)
Affinity DataIC50: 19nMAssay Description:In vitro inhibition of acid induced swelling in rat platelets by 50% as a measure of NHE-1 inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Rat)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50115271(N-[7-(2,5-dichloro-3-thienyl)-4-methyl-5,6,7,8-tet...)
Affinity DataIC50: 19nMAssay Description:In vitro inhibition of acid induced swelling in rat platelets by 50% as a measure of NHE-1 inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Rat)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50115267(N-[7-(2-chlorophenyl)-4-methyl-(7S)-5,6,7,8-tetrah...)
Affinity DataIC50: 20nMAssay Description:In vitro inhibition of acid induced swelling in rat platelets by 50% as a measure of NHE-1 inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Rat)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50115268(N-[7-(2-chloro-3-thienyl)-4-methyl-5,6,7,8-tetrahy...)
Affinity DataIC50: 22nMAssay Description:In vitro inhibition of acid induced swelling in rat platelets by 50% as a measure of NHE-1 inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Rat)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50115238(N-[7-(2-chlorophenyl)-4-methyl-5,6,7,8-tetrahydro-...)
Affinity DataIC50: 26nMAssay Description:In vitro inhibition of acid induced swelling in rat platelets by 50% as a measure of NHE-1 inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Rat)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50115245(N-[4-methyl-7-(3-thienyl)-5,6,7,8-tetrahydro-5-qui...)
Affinity DataIC50: 30nMAssay Description:In vitro inhibition of acid induced swelling in rat platelets by 50% as a measure of NHE-1 inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Rat)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50115236(N-[7-(5-fluoro-2-methoxyphenyl)-4-methyl-5,6,7,8-t...)
Affinity DataIC50: 32nMAssay Description:In vitro inhibition of acid induced swelling in rat platelets by 50% as a measure of NHE-1 inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Rat)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50115233(N-[7-(2-fluorophenyl)-4-methyl-5,6,7,8-tetrahydro-...)
Affinity DataIC50: 32nMAssay Description:In vitro inhibition of acid induced swelling in rat platelets by 50% as a measure of NHE-1 inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Rat)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50115270((R)-N-[7-(2,5-dichloro-3-thienyl)-4-methyl-(7R)-5,...)
Affinity DataIC50: 33nMAssay Description:In vitro inhibition of acid induced swelling in rat platelets by 50% as a measure of NHE-1 inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Rat)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50115264(N-[3-methyl-6-(2-methylphenyl)-4,5,6,7-tetrahydro-...)
Affinity DataIC50: 34nMAssay Description:In vitro inhibition of acid induced swelling in rat platelets by 50% as a measure of NHE-1 inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Rat)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50115258(N-[7-(5-fluoro-2-methylphenyl)-4-methyl-5,6,7,8-te...)
Affinity DataIC50: 37nMAssay Description:In vitro inhibition of acid induced swelling in rat platelets by 50% as a measure of NHE-1 inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Rat)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50115257(N-[7-(2,5-difluorophenyl)-4-methyl-5,6,7,8-tetrahy...)
Affinity DataIC50: 39nMAssay Description:In vitro inhibition of acid induced swelling in rat platelets by 50% as a measure of NHE-1 inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Rat)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50115256(N-[7-(2-chlorophenyl)-4-methyl-5,6,7,8-tetrahydro-...)
Affinity DataIC50: 40nMAssay Description:In vitro inhibition of acid induced swelling in rat platelets by 50% as a measure of NHE-1 inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Rat)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50115252(N-[4-methyl-7-(2-thienyl)-5,6,7,8-tetrahydro-5-qui...)
Affinity DataIC50: 47nMAssay Description:In vitro inhibition of acid induced swelling in rat platelets by 50% as a measure of NHE-1 inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Rat)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50115260(N-[7-(3,5-dichloro-2-thienyl)-4-methyl-5,6,7,8-tet...)
Affinity DataIC50: 49nMAssay Description:In vitro inhibition of acid induced swelling in rat platelets by 50% as a measure of NHE-1 inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Rat)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50115234(N-[7-(2-chlorophenyl)-4-methoxy-5,6,7,8-tetrahydro...)
Affinity DataIC50: 50nMAssay Description:In vitro inhibition of acid induced swelling in rat platelets by 50% as a measure of NHE-1 inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Rat)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50115241(N-[6-(2-chlorophenyl)-3-methyl-4,5,6,7-tetrahydro-...)
Affinity DataIC50: 55nMAssay Description:In vitro inhibition of acid induced swelling in rat platelets by 50% as a measure of NHE-1 inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Rat)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50115259(N-[7-(2-bromophenyl)-4-methyl-5,6,7,8-tetrahydro-5...)
Affinity DataIC50: 56nMAssay Description:In vitro inhibition of acid induced swelling in rat platelets by 50% as a measure of NHE-1 inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Rat)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50115228(N-[4-methyl-7-(2-methylphenyl)-5,6,7,8-tetrahydro-...)
Affinity DataIC50: 57nMAssay Description:In vitro inhibition of acid induced swelling in rat platelets by 50% as a measure of NHE-1 inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Rat)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50115255(N-[7-(2,5-dichlorophenyl)-4-methyl-5,6,7,8-tetrahy...)
Affinity DataIC50: 58nMAssay Description:In vitro inhibition of acid induced swelling in rat platelets by 50% as a measure of NHE-1 inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Rat)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50115229(N-[7-(3-chlorophenyl)-4-methyl-5,6,7,8-tetrahydro-...)
Affinity DataIC50: 61nMAssay Description:In vitro inhibition of acid induced swelling in rat platelets by 50% as a measure of NHE-1 inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Rat)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50058759(CHEMBL436559 | N-(diaminomethylene)-4-isopropyl-3-...)
Affinity DataIC50: 75nMAssay Description:In vitro inhibition of acid induced swelling in rat platelets by 50% as a measure of NHE-1 inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Rat)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50115235(N-[6-(2-chlorophenyl)-3-methyl-4,5,6,7-tetrahydrob...)
Affinity DataIC50: 82nMAssay Description:In vitro inhibition of acid induced swelling in rat platelets by 50% as a measure of NHE-1 inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Rat)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50115269(N-[7-(2,3-dichlorophenyl)-4-methyl-5,6,7,8-tetrahy...)
Affinity DataIC50: 89nMAssay Description:In vitro inhibition of acid induced swelling in rat platelets by 50% as a measure of NHE-1 inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Rat)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50115261(N-(4-methyl-7-phenyl-5,6,7,8-tetrahydro-5-quinolin...)
Affinity DataIC50: 91nMAssay Description:In vitro inhibition of acid induced swelling in rat platelets by 50% as a measure of NHE-1 inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Rat)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50115253(N-[7-(2-methoxyphenyl)-4-methyl-5,6,7,8-tetrahydro...)
Affinity DataIC50: 100nMAssay Description:In vitro inhibition of acid induced swelling in rat platelets by 50% as a measure of NHE-1 inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Rat)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50115242(N-[7-(2-furyl)-4-methyl-5,6,7,8-tetrahydro-5-quino...)
Affinity DataIC50: 110nMAssay Description:In vitro inhibition of acid induced swelling in rat platelets by 50% as a measure of NHE-1 inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Rat)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50115249(N-(2,4-dimethyl-7-phenyl-5,6,7,8-tetrahydro-5-quin...)
Affinity DataIC50: 180nMAssay Description:In vitro inhibition of acid induced swelling in rat platelets by 50% as a measure of NHE-1 inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Rat)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50115244(N-[2-(2-chlorophenyl)-5-methyl-3,4-dihydro-2H-4-ch...)
Affinity DataIC50: 200nMAssay Description:In vitro inhibition of acid induced swelling in rat platelets by 50% as a measure of NHE-1 inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Rat)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50115262((R)-N-[7-(5-fluoro-2-methylphenyl)-4-methyl-(7R)-5...)
Affinity DataIC50: 220nMAssay Description:In vitro inhibition of acid induced swelling in rat platelets by 50% as a measure of NHE-1 inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Rat)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50115263(N-[6-(2-chlorophenyl)-3-methyl-4,5,6,7-tetrahydrob...)
Affinity DataIC50: 220nMAssay Description:In vitro inhibition of acid induced swelling in rat platelets by 50% as a measure of NHE-1 inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Rat)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50115231(N-[7-(2-chlorophenyl)-4-methyl-5,6,7,8-tetrahydro-...)
Affinity DataIC50: 240nMAssay Description:In vitro inhibition of acid induced swelling in rat platelets by 50% as a measure of NHE-1 inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Rat)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50115265(N-[7-(2,4-dichlorophenyl)-4-methyl-5,6,7,8-tetrahy...)
Affinity DataIC50: 340nMAssay Description:In vitro inhibition of acid induced swelling in rat platelets by 50% as a measure of NHE-1 inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Rat)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50115247(N-[2-(2-chlorophenyl)-5-methyl-4H-4-chromenylidenm...)
Affinity DataIC50: 360nMAssay Description:In vitro inhibition of acid induced swelling in rat platelets by 50% as a measure of NHE-1 inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Rat)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50115237(N-(7-phenyl-5,6,7,8-tetrahydro-5-quinolinyliden(im...)
Affinity DataIC50: 410nMAssay Description:In vitro inhibition of acid induced swelling in rat platelets by 50% as a measure of NHE-1 inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Rat)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50115230(N-[7-(4-chlorophenyl)-4-methyl-5,6,7,8-tetrahydro-...)
Affinity DataIC50: 550nMAssay Description:In vitro inhibition of acid induced swelling in rat platelets by 50% as a measure of NHE-1 inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Rat)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50115251(N-[7-(2-chlorophenyl)-4-methyl-(7S)-5,6,7,8-tetrah...)
Affinity DataIC50: 700nMAssay Description:In vitro inhibition of acid induced swelling in rat platelets by 50% as a measure of NHE-1 inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Rat)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50115240(N-[2-(2-benzyloxy-3-methoxyphenyl)-(E)-1-meth(imin...)
Affinity DataIC50: 2.30E+3nMAssay Description:In vitro inhibition of acid induced swelling in rat platelets by 50% as a measure of NHE-1 inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Rat)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50115250(N-(2-methyl-7-phenyl-5,6,7,8-tetrahydro-5-quinolin...)
Affinity DataIC50: 2.80E+3nMAssay Description:In vitro inhibition of acid induced swelling in rat platelets by 50% as a measure of NHE-1 inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Rat)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50115254(N-(2-phenyl-3,4-dihydro-2H-4-chromenyliden(imine))...)
Affinity DataIC50: 3.30E+3nMAssay Description:In vitro inhibition of acid induced swelling in rat platelets by 50% as a measure of NHE-1 inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Rat)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50115232(N-(6-phenyl-4,5,6,7-tetrahydro-1H-4-indolyliden(im...)
Affinity DataIC50: 3.50E+3nMAssay Description:In vitro inhibition of acid induced swelling in rat platelets by 50% as a measure of NHE-1 inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Rat)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50115266(N-(2-phenyl-4H-4-chromenyliden(imine))iminomethane...)
Affinity DataIC50: 6.40E+3nMAssay Description:In vitro inhibition of acid induced swelling in rat platelets by 50% as a measure of NHE-1 inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed