Compile Data Set for Download or QSAR
Report error Found 24 Enz. Inhib. hit(s) with all data for entry = 50011890
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM26198(Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...)
Affinity DataIC50: 1nMAssay Description:Inhibition of Tyrosine kinase 2 kinaseMore data for this Ligand-Target Pair
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PubMed
TargetTyrosine-protein kinase JAK2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM26198(Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...)
Affinity DataIC50: 1nMAssay Description:Inhibition of protein kinase Jak 2More data for this Ligand-Target Pair
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PubMed
TargetTyrosine-protein kinase JAK3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM26198(Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...)
Affinity DataIC50: 5nMAssay Description:Inhibition of protein kinase Jak 3More data for this Ligand-Target Pair
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PubMed
TargetTyrosine-protein kinase JAK1(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM26198(Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...)
Affinity DataIC50: 15nMAssay Description:Inhibition of murine Jak 1 protein kinaseMore data for this Ligand-Target Pair
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PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1/2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM26198(Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...)
Affinity DataIC50: 160nMAssay Description:Inhibition of mitogen-activated protein kinase ERKMore data for this Ligand-Target Pair
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PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM26198(Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...)
Affinity DataIC50: 300nMAssay Description:Inhibition of I-kappa-B kinase 2More data for this Ligand-Target Pair
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PubMed
TargetTyrosine-protein kinase Fyn(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM26198(Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...)
Affinity DataIC50: 500nMAssay Description:Inhibition of protein kinase FynMore data for this Ligand-Target Pair
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PubMed
TargetVascular endothelial growth factor receptor 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM26198(Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...)
Affinity DataIC50: 690nMAssay Description:Inhibition of Vascular endothelial growth factor receptor 3More data for this Ligand-Target Pair
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PubMed
TargetFibroblast growth factor receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM26198(Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...)
Affinity DataIC50: 940nMAssay Description:Inhibition of Fibroblast growth factor receptor 2More data for this Ligand-Target Pair
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PubMed
TargetProtein kinase C alpha type(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM26198(Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of protein kinase C alphaMore data for this Ligand-Target Pair
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PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM26198(Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of Vascular endothelial growth factor receptor 2More data for this Ligand-Target Pair
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PubMed
TargetFibroblast growth factor receptor 1/2/3/4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM26198(Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...)
Affinity DataIC50: 1.48E+3nMAssay Description:Inhibition of Fibroblast growth factor receptorMore data for this Ligand-Target Pair
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PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM26198(Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...)
Affinity DataIC50: 1.49E+3nMAssay Description:Inhibition of Platelet-derived growth factor receptorMore data for this Ligand-Target Pair
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PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM26198(Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...)
Affinity DataIC50: 1.52E+3nMAssay Description:Inhibition of Vascular endothelial growth factor receptor 1More data for this Ligand-Target Pair
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PubMed
TargetMitogen-activated protein kinase 1/3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM26198(Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...)
Affinity DataIC50: 1.78E+3nMAssay Description:Inhibition of Dual specificity mitogen-activated protein kinase kinase (MEK)More data for this Ligand-Target Pair
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PubMed
TargetTyrosine-protein kinase CSK(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM26198(Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of Tyrosine-protein kinase CSKMore data for this Ligand-Target Pair
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PubMed
TargetCyclin-dependent kinase 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM26198(Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of cyclin dependent kinase 2More data for this Ligand-Target Pair
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PubMed
TargetTyrosine-protein kinase HCK(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM26198(Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...)
Affinity DataIC50: 7.70E+3nMAssay Description:Inhibition of protein kinase HckMore data for this Ligand-Target Pair
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PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM26198(Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of Src protein tyrosine kinaseMore data for this Ligand-Target Pair
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PubMed
TargetTyrosine-protein kinase Lck(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM26198(Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
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PubMed
TargetTyrosine-protein kinase Lck(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM26198(Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
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PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM26198(Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of protein kinase RafMore data for this Ligand-Target Pair
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PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM26198(Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of Mitogen-activated protein kinase p38More data for this Ligand-Target Pair
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PubMed
TargetAngiopoietin-1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM26198(Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...)
Affinity DataIC50: 2.40E+4nMAssay Description:Inhibition of Tek kinaseMore data for this Ligand-Target Pair
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PubMed