Compile Data Set for Download or QSAR
Report error Found 6 Enz. Inhib. hit(s) with all data for entry = 50038587
TargetDNA topoisomerase 2-alpha(Human)
Osaka University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50377927(Clerodol | Fagarasterol | Farganasterol | Monogyno...)
Affinity DataIC50: 1.04E+4nMAssay Description:Inhibition of human 1 unit topoisomerase 2alpha catalytic activity assessed as relaxation of 198 ng supercoiled pBR322 DNA by agarose gel electrophor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha(Human)
Osaka University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50260250(Olean-12-en-3beta,15alpha-diol | CHEMBL491188)
Affinity DataIC50: 1.75E+4nMAssay Description:Inhibition of human 1 unit topoisomerase 2alpha catalytic activity assessed as relaxation of 198 ng supercoiled pBR322 DNA by agarose gel electrophor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha(Human)
Osaka University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM23207((1R,2R,5S,8R,9R,10R,13R,14R,17S,19R)-5-(hydroxymet...)
Affinity DataIC50: 3.86E+4nMAssay Description:Inhibition of human 1 unit topoisomerase 2alpha catalytic activity assessed as relaxation of 198 ng supercoiled pBR322 DNA by agarose gel electrophor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha(Human)
Osaka University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50260252(olean-12-en-3bea,15alpha,24-triol | CHEMBL489552)
Affinity DataIC50: 3.87E+4nMAssay Description:Inhibition of human 1 unit topoisomerase 2alpha catalytic activity assessed as relaxation of 198 ng supercoiled pBR322 DNA by agarose gel electrophor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha(Human)
Osaka University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50127140(4'-Demethylepipodophyllotoxin 9-(4,6-O-(R)-ethylid...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human 1 unit topoisomerase 2alpha catalytic activity assessed as relaxation of 198 ng supercoiled pBR322 DNA by agarose gel electrophor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDNA topoisomerase 2-alpha(Human)
Osaka University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50260251(olean-12-en-3beta,24-diol | CHEMBL489551)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of human 1 unit topoisomerase 2alpha catalytic activity assessed as relaxation of 198 ng supercoiled pBR322 DNA by agarose gel electrophor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed