Compile Data Set for Download or QSAR
Report error Found 30 Enz. Inhib. hit(s) with all data for entry = 50036857
TargetSigma non-opioid intracellular receptor 1(Rat)
Otsuka Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50084312((+)-1,2,3,4,5,6-hexahydro-6,11-dimethyl-3-(2-prope...)
Affinity DataIC50: 50nMAssay Description:Binding affinity for sigma receptor was evaluated by the inhibitory effect on [3H]DTG to rat whole brain membranes (high)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Otsuka Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50084320(5-Chloro-1-{3-[4-(3-methoxy-phenyl)-piperazin-1-yl...)
Affinity DataIC50: 130nMAssay Description:Binding affinity for sigma receptor was evaluated by the inhibitory effect on [3H]DTG to rat whole brain membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Otsuka Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50084310(1-{3-[4-(3-Bromo-phenyl)-piperazin-1-yl]-propyl}-5...)
Affinity DataIC50: 150nMAssay Description:Binding affinity for sigma receptor was evaluated by the inhibitory effect on [3H]DTG to rat whole brain membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Otsuka Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50369619(CHEMBL1743967)
Affinity DataIC50: 240nMAssay Description:Binding affinity for sigma receptor was evaluated by the inhibitory effect on [3H]DTG to rat whole brain membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Otsuka Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50084307(1-{3-[4-(2-Chloro-phenyl)-piperazin-1-yl]-propyl}-...)
Affinity DataIC50: 260nMAssay Description:Binding affinity for sigma receptor was evaluated by the inhibitory effect on [3H]DTG to rat whole brain membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Otsuka Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50084325(5-Chloro-1-{3-[4-(3-propoxy-phenyl)-piperazin-1-yl...)
Affinity DataIC50: 370nMAssay Description:Binding affinity for sigma receptor was evaluated by the inhibitory effect on [3H]DTG to rat whole brain membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Otsuka Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50084313(5-Chloro-1-{3-[4-(3-nitro-phenyl)-piperazin-1-yl]-...)
Affinity DataIC50: 390nMAssay Description:Binding affinity for sigma receptor was evaluated by the inhibitory effect on [3H]DTG to rat whole brain membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Otsuka Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM81982(CAS_97-39-2 | cid_7333 | Di-o-tolylguanidine | DIT...)
Affinity DataIC50: 400nMAssay Description:Binding affinity for sigma receptor was evaluated by the inhibitory effect on [3H]DTG to rat whole brain membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Otsuka Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50084308(1-{3-[4-(3-Bromo-phenyl)-piperazin-1-yl]-propyl}-5...)
Affinity DataIC50: 420nMAssay Description:Binding affinity for sigma receptor was evaluated by the inhibitory effect on [3H]DTG to rat whole brain membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Otsuka Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50084324(1-{3-[4-(4-Chloro-phenyl)-piperazin-1-yl]-propyl}-...)
Affinity DataIC50: 460nMAssay Description:Binding affinity for sigma receptor was evaluated by the inhibitory effect on [3H]DTG to rat whole brain membranes.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Otsuka Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50084311(5-Methoxy-1-{3-[4-(3-trifluoromethyl-phenyl)-piper...)
Affinity DataIC50: 490nMAssay Description:Binding affinity for sigma receptor was evaluated by the inhibitory effect on [3H]DTG to rat whole brain membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Otsuka Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50084321(1-{3-[4-(3-Chloro-phenyl)-piperazin-1-yl]-propyl}-...)
Affinity DataIC50: 600nMAssay Description:Binding affinity for sigma receptor was evaluated by the inhibitory effect on [3H]DTG to rat whole brain membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Otsuka Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50084326(1-{3-[4-(3-Chloro-phenyl)-piperazin-1-yl]-propyl}-...)
Affinity DataIC50: 620nMAssay Description:Binding affinity for sigma receptor was evaluated by the inhibitory effect on [3H]DTG to rat whole brain membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Otsuka Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50084329(1-{3-[4-(3-Chloro-phenyl)-piperazin-1-yl]-propyl}-...)
Affinity DataIC50: 650nMAssay Description:Binding affinity for sigma receptor was evaluated by the inhibitory effect on [3H]DTG to rat whole brain membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Otsuka Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50084323(N-(3-{4-[3-(5-Chloro-2-oxo-3,4-dihydro-2H-quinolin...)
Affinity DataIC50: 670nMAssay Description:Binding affinity for sigma receptor was evaluated by the inhibitory effect on [3H]DTG to rat whole brain membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Otsuka Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50084319(1-{3-[4-(3-Amino-phenyl)-piperazin-1-yl]-propyl}-5...)
Affinity DataIC50: 710nMAssay Description:Binding affinity for sigma receptor was evaluated by the inhibitory effect on [3H]DTG to rat whole brain membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Otsuka Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50084315(1-{3-[4-(3-Hydroxy-phenyl)-piperazin-1-yl]-propyl}...)
Affinity DataIC50: 810nMAssay Description:Binding affinity for sigma receptor was evaluated by the inhibitory effect on [3H]DTG to rat whole brain membranes.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Otsuka Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50084305(5-Methoxy-1-{3-[4-(3-trifluoromethyl-phenyl)-piper...)
Affinity DataIC50: 820nMAssay Description:Binding affinity for sigma receptor was evaluated by the inhibitory effect on [3H]DTG to rat whole brain membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Otsuka Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50084316(1-(4-Fluoro-phenyl)-4-(5-fluoro-pyridin-2-yl)-4-pi...)
Affinity DataIC50: 860nMAssay Description:Binding affinity for sigma receptor was evaluated by the inhibitory effect on [3H]DTG to rat whole brain membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Otsuka Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50084306(5-Methoxy-1-{3-[4-(3-nitro-phenyl)-piperazin-1-yl]...)
Affinity DataIC50: 870nMAssay Description:Binding affinity for sigma receptor was evaluated by the inhibitory effect on [3H]DTG to rat whole brain membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Otsuka Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50084322(1-{3-[4-(3-Chloro-phenyl)-piperazin-1-yl]-propyl}-...)
Affinity DataIC50: 870nMAssay Description:Binding affinity for sigma receptor was evaluated by the inhibitory effect on [3H]DTG to rat whole brain membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Otsuka Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50084309(1-{3-[4-(3-Chloro-phenyl)-piperazin-1-yl]-propyl}-...)
Affinity DataIC50: 980nMAssay Description:Binding affinity for sigma receptor was evaluated by the inhibitory effect on [3H]DTG to rat whole brain membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Otsuka Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50084330(1-{3-[4-(3-Chloro-phenyl)-piperazin-1-yl]-propyl}-...)
Affinity DataIC50: 1.13E+3nMAssay Description:Binding affinity for sigma receptor was evaluated by the inhibitory effect on [3H]DTG to rat whole brain membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Otsuka Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50084327(1-{3-[4-(3-Amino-phenyl)-piperazin-1-yl]-propyl}-5...)
Affinity DataIC50: 1.21E+3nMAssay Description:Binding affinity for sigma receptor was evaluated by the inhibitory effect on [3H]DTG to rat whole brain membranes.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Otsuka Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50084317(1-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-propyl}-...)
Affinity DataIC50: 1.32E+3nMAssay Description:Binding affinity for sigma receptor was evaluated by the inhibitory effect on [3H]DTG to rat whole brain membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Otsuka Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50084331(3-{4-[3-(5-Methoxy-2-oxo-3,4-dihydro-2H-quinolin-1...)
Affinity DataIC50: 2.47E+3nMAssay Description:Binding affinity for sigma receptor was evaluated by the inhibitory effect on [3H]DTG to rat whole brain membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Otsuka Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50019742(9-(3-(3,5-dimethylpiperazin-1-yl)propyl)-9H-carbaz...)
Affinity DataIC50: 2.50E+3nMAssay Description:Binding affinity for sigma receptor was evaluated by the inhibitory effect on [3H]DTG to rat whole brain membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Otsuka Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50084312((+)-1,2,3,4,5,6-hexahydro-6,11-dimethyl-3-(2-prope...)
Affinity DataIC50: 8.94E+3nMAssay Description:Binding affinity for sigma receptor was evaluated by the inhibitory effect on [3H]DTG to rat whole brain membranes (low)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Otsuka Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50084328(Benzoic acid 2-oxo-1-[3-(4-phenyl-piperazin-1-yl)-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Binding affinity for sigma receptor was evaluated by the inhibitory effect on [3H]DTG to rat whole brain membranes.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Otsuka Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50084314(N-(7-Hydroxy-2,2,4,6-tetramethyl-indan-1-yl)-2-[4-...)
Affinity DataIC50: 1.50E+4nMAssay Description:Binding affinity for sigma receptor was evaluated by the inhibitory effect on [3H]DTG to rat whole brain membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed