Compile Data Set for Download or QSAR
Report error Found 33 Enz. Inhib. hit(s) with all data for entry = 50009387
TargetDihydrofolate reductase(Rat)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM18268(5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}...)
Affinity DataIC50: 3nMAssay Description:Inhibitory activity against DHFR (Dihydrofolate reductase) from Rat liverMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM18268(5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}...)
Affinity DataIC50: 10nMAssay Description:Inhibitory activity against DHFR (Dihydrofolate reductase) from Toxoplasma gondii.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDihydrofolate reductase(Mycobacterium avium)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM18506(6-{2-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8...)
Affinity DataIC50: 12nMAssay Description:Inhibitory activity against DHFR (Dihydrofolate reductase) from Mycobacterium aviumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50082920(6-Carbazol-9-ylmethyl-pteridine-2,4-diamine | CHEM...)
Affinity DataIC50: 12nMAssay Description:Inhibitory activity against DHFR (Dihydrofolate reductase) from Toxoplasma gondii.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDihydrofolate reductase(Mycobacterium avium)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50082923(6-(9H-Acridin-10-ylmethyl)-pteridine-2,4-diamine |...)
Affinity DataIC50: 17nMAssay Description:Inhibitory activity against DHFR (Dihydrofolate reductase) from Mycobacterium aviumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDihydrofolate reductase(Rat)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50082923(6-(9H-Acridin-10-ylmethyl)-pteridine-2,4-diamine |...)
Affinity DataIC50: 27nMAssay Description:Inhibitory activity against DHFR (Dihydrofolate reductase) from Rat liverMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDihydrofolate reductase(Mycobacterium avium)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50082922(6-Phenothiazin-10-ylmethyl-pteridine-2,4-diamine |...)
Affinity DataIC50: 29nMAssay Description:Inhibitory activity against DHFR (Dihydrofolate reductase) from Mycobacterium aviumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50082923(6-(9H-Acridin-10-ylmethyl)-pteridine-2,4-diamine |...)
Affinity DataIC50: 29nMAssay Description:Inhibitory activity against DHFR (Dihydrofolate reductase) from Toxoplasma gondii.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM18268(5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}...)
Affinity DataIC50: 42nMAssay Description:Inhibitory activity against DHFR (Dihydrofolate reductase) from Pneumocystis carinii.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50082923(6-(9H-Acridin-10-ylmethyl)-pteridine-2,4-diamine |...)
Affinity DataIC50: 42nMAssay Description:Inhibitory activity against DHFR (Dihydrofolate reductase) from Pneumocystis carinii.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM18506(6-{2-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8...)
Affinity DataIC50: 43nMAssay Description:Inhibitory activity against DHFR (Dihydrofolate reductase) from Toxoplasma gondii.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDihydrofolate reductase(Rat)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50082920(6-Carbazol-9-ylmethyl-pteridine-2,4-diamine | CHEM...)
Affinity DataIC50: 55nMAssay Description:Inhibitory activity against DHFR (Dihydrofolate reductase) from Rat liverMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50082920(6-Carbazol-9-ylmethyl-pteridine-2,4-diamine | CHEM...)
Affinity DataIC50: 100nMAssay Description:Inhibitory activity against DHFR (Dihydrofolate reductase) from Pneumocystis carinii.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50082922(6-Phenothiazin-10-ylmethyl-pteridine-2,4-diamine |...)
Affinity DataIC50: 110nMAssay Description:Inhibitory activity against DHFR (Dihydrofolate reductase) from Toxoplasma gondii.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50082922(6-Phenothiazin-10-ylmethyl-pteridine-2,4-diamine |...)
Affinity DataIC50: 120nMAssay Description:Inhibitory activity against DHFR (Dihydrofolate reductase) from Pneumocystis carinii.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDihydrofolate reductase(Mycobacterium avium)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM18069(CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...)
Affinity DataIC50: 190nMAssay Description:Inhibitory activity against DHFR (Dihydrofolate reductase) from Mycobacterium aviumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetDihydrofolate reductase(Rat)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50082922(6-Phenothiazin-10-ylmethyl-pteridine-2,4-diamine |...)
Affinity DataIC50: 200nMAssay Description:Inhibitory activity against DHFR (Dihydrofolate reductase) from Rat liverMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM18506(6-{2-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8...)
Affinity DataIC50: 210nMAssay Description:Inhibitory activity against DHFR (Dihydrofolate reductase) from Pneumocystis carinii.More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50082924(6-(10,11-Dihydro-dibenzo[b,f]azepin-5-ylmethyl)-pt...)
Affinity DataIC50: 910nMAssay Description:Inhibitory activity against DHFR (Dihydrofolate reductase) from Toxoplasma gondii.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50082921(6-[(Diphenylamino)-methyl]-pteridine-2,4-diamine |...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibitory activity against DHFR (Dihydrofolate reductase) from Toxoplasma gondii.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50082924(6-(10,11-Dihydro-dibenzo[b,f]azepin-5-ylmethyl)-pt...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibitory activity against DHFR (Dihydrofolate reductase) from Pneumocystis carinii.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50082925(6-Phenoxazin-10-ylmethyl-pteridine-2,4-diamine | C...)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibitory activity against DHFR (Dihydrofolate reductase) from Toxoplasma gondii.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDihydrofolate reductase(Mycobacterium avium)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50082925(6-Phenoxazin-10-ylmethyl-pteridine-2,4-diamine | C...)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibitory activity against DHFR (Dihydrofolate reductase) from Mycobacterium aviumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM18069(CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibitory activity against DHFR (Dihydrofolate reductase) from Toxoplasma gondii.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50082925(6-Phenoxazin-10-ylmethyl-pteridine-2,4-diamine | C...)
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibitory activity against DHFR (Dihydrofolate reductase) from Pneumocystis carinii.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDihydrofolate reductase(Mycobacterium avium)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50082921(6-[(Diphenylamino)-methyl]-pteridine-2,4-diamine |...)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibitory activity against DHFR (Dihydrofolate reductase) from Mycobacterium aviumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDihydrofolate reductase(Rat)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50082921(6-[(Diphenylamino)-methyl]-pteridine-2,4-diamine |...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibitory activity against DHFR (Dihydrofolate reductase) from Rat liverMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDihydrofolate reductase(Rat)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM18506(6-{2-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8...)
Affinity DataIC50: 4.40E+3nMAssay Description:Inhibitory activity against DHFR (Dihydrofolate reductase) from Rat liverMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50082921(6-[(Diphenylamino)-methyl]-pteridine-2,4-diamine |...)
Affinity DataIC50: 4.90E+3nMAssay Description:Inhibitory activity against DHFR (Dihydrofolate reductase) from Pneumocystis carinii.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDihydrofolate reductase(Rat)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50082924(6-(10,11-Dihydro-dibenzo[b,f]azepin-5-ylmethyl)-pt...)
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibitory activity against DHFR (Dihydrofolate reductase) from Rat liverMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM18069(CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibitory activity against DHFR (Dihydrofolate reductase) from Pneumocystis carinii.More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetDihydrofolate reductase(Rat)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50082925(6-Phenoxazin-10-ylmethyl-pteridine-2,4-diamine | C...)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibitory activity against DHFR (Dihydrofolate reductase) from Rat liverMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDihydrofolate reductase(Rat)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM18069(CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...)
Affinity DataIC50: 1.30E+5nMAssay Description:Inhibitory activity against DHFR (Dihydrofolate reductase) from Rat liver. More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)