Compile Data Set for Download or QSAR
Report error Found 32 of ic50 data for polymerid = 9641
TargetHistone-lysine N-methyltransferase NSD3(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM50627886(CHEMBL5438312)
Affinity DataIC50: 1nMAssay Description:Inhibition of NSD3 degradation in human KMS-11 cells assessed as reduction in H3K36me2 levels by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM567822(US11420970, Example 23)
Affinity DataIC50: 1nMAssay Description:Inhibition of NSD3 degradation in human KMS-11 cells assessed as reduction in H3K36me2 levels by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM567825(US11420970, Example 26)
Affinity DataIC50: 1nMAssay Description:Inhibition of NSD3 degradation in human KMS-11 cells assessed as reduction in H3K36me2 levels by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM567828(US11420970, Example 29)
Affinity DataIC50: 1nMAssay Description:Inhibition of NSD3 degradation in human KMS-11 cells assessed as reduction in H3K36me2 levels by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM567831(US11420970, Example 32)
Affinity DataIC50: 1nMAssay Description:Inhibition of NSD3 degradation in human KMS-11 cells assessed as reduction in H3K36me2 levels by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM567955((R)-1-((R)-3-amino-1-(4-((6-amino-9H-purin-9-yl)me...)
Affinity DataIC50: 1nMAssay Description:Inhibition of NSD3 degradation in human KMS-11 cells assessed as reduction in H3K36me2 levels by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM567959((R)-1-((R)-3-amino-1-(4-((6-amino-9H-purin-9-yl)me...)
Affinity DataIC50: 1nMAssay Description:Inhibition of NSD3 degradation in human KMS-11 cells assessed as reduction in H3K36me2 levels by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM50594308(CHEMBL5186268)
Affinity DataIC50: 110nMAssay Description:Antagonist activity against recombinant human GST-tagged NSD3 PWWP1 domain (247 to 398 residues) expressed in Escherichia coli BL21(DE3) incubated fo...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM50555101(CHEMBL4778517)
Affinity DataIC50: 200nMAssay Description:Inhibition of GST-tagged NSD3-PWWP1 domain (247 to 398 residues) (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM50555101(CHEMBL4778517)
Affinity DataIC50: 200nMAssay Description:Inhibition of NSD3 PWWP1 domain (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM50555101(CHEMBL4778517)
Affinity DataIC50: 200nMAssay Description:Antagonist activity against recombinant human GST-tagged NSD3 PWWP1 domain (247 to 398 residues) expressed in Escherichia coli BL21(DE3) incubated fo...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM50608080(CHEMBL5277519)
Affinity DataIC50: 203nMAssay Description:Antagonist activity against recombinant human GST-tagged NSD3 PWWP1 domain (247 to 398 residues) incubated for 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM50106497(NSC-663284 | 6-Chloro-7-(2-morpholin-4-yl-ethylami...)
Affinity DataIC50: 260nMAssay Description:Inhibition of N-terminal GST-fused recombinant human NSD3 (1021 to 1322 residues) expressed in Escherichia coli using SAM as substrate preincubated f...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM50106497(NSC-663284 | 6-Chloro-7-(2-morpholin-4-yl-ethylami...)
Affinity DataIC50: 340nMAssay Description:Inhibition of NSD3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM50616733(CHEMBL5422549)
Affinity DataIC50: 750nMAssay Description:Inhibition of NSD3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM50162774(ABT-199 | Venetoclax | US11420968, Example ABT-199)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of N-terminal GST-fused recombinant human NSD3 (1021 to 1322 residues) expressed in Escherichia coli using SAM as substrate preincubated f...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM50629735(CHEMBL5427539)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of NSD3 PWWP1 domain (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM50388091(CHEMBL2058156)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of N-terminal GST-fused recombinant human NSD3 (1021 to 1322 residues) expressed in Escherichia coli using SAM as substrate preincubated f...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM50324210((3S,3aR)-2-(3-Chloro-4-cyanophenyl)-3-cyclopentyl-...)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of N-terminal GST-fused recombinant human NSD3 (1021 to 1322 residues) expressed in Escherichia coli using SAM as substrate preincubated f...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM50315537(chaetocin | CHEMBL1089316)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of N-terminal GST-fused recombinant human NSD3 (1021 to 1322 residues) expressed in Escherichia coli using SAM as substrate preincubated f...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM50629733(CHEMBL5414580)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of N-terminal His-TEV-tagged human NSD3 (1054 to 1285 residues ) expressed in Escherichia coli using 3[H] SAM as substrate measured after ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM50627878(CHEMBL5402803)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of NSD3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM50629734(CHEMBL5431913)
Affinity DataIC50: 5.20E+3nMAssay Description:Inhibition of NSD3 PWWP1 domain (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM50315537(chaetocin | CHEMBL1089316)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of human NSD3 overexpressed in Escherichia coli BL21(DE3) using nucleosome as substrate by SPA analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM50179360(CHEMBL3040216)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of human NSD3 overexpressed in Escherichia coli BL21(DE3) using nucleosome as substrate by SPA analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM50629737(CHEMBL5416266)
Affinity DataIC50: 6.00E+4nMAssay Description:Inhibition of human NSD3 SET domain using histone H3 as substrate assessed as reduction in H3K36 methylationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM50629737(CHEMBL5416266)
Affinity DataIC50: 6.00E+4nMAssay Description:Inhibition of NSD3 (unknown origin) using H3K36 as substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM50378739(SINEFUNGIN | jm2c00120, Sinefungin)
Affinity DataIC50: 6.10E+4nMAssay Description:Inhibition of human NSD3 overexpressed in Escherichia coli BL21(DE3) using nucleosome as substrate by SPA analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM50498655(CHEMBL1895209)
Affinity DataIC50: 9.50E+4nMAssay Description:Inhibition of human NSD3 SET domain assessed as reduction in H3K36 methylationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM50300028(N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-meth...)
Affinity DataIC50: 9.50E+4nMAssay Description:Inhibition of human recombinant NSD3 (3084 to 3954 residues) expressed in Escherichia coli BL21 (DE3) incubated for 4 hrs by scintillation/filter ass...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM50498655(CHEMBL1895209)
Affinity DataIC50: 9.50E+4nMAssay Description:Inhibition of human NSD3-SET using histone H3.1 as substrate incubated for 1 hr by Western blot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM225230(EED226 | US11013745, Compound EED226)
Affinity DataIC50: 1.00E+5nMAssay Description:All HMT reactions were performed as described previously [Nasveschuk et al., ACS Med. Chem. Lett., 5:378-383].More data for this Ligand-Target Pair
In DepthDetails Article
PubMed