Compile Data Set for Download or QSAR
Report error Found 89 of ic50 data for polymerid = 920,4523
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 0.0310nMAssay Description:Inhibition of human CAMK2A using KKALRRQETVDAL as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 0.0640nMAssay Description:Inhibition of human CAMK2A using KKALRRQETVDAL as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50168283((3-hydroxyphenyl)acetic acid | 3-hydroxyphenylacet...)
Affinity DataIC50: 0.130nMAssay Description:Inhibition of [3H]NCS-382 binding to CaMK2alpha in rat cerebrocortical membranesMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 1nMAssay Description:Inhibition of CamK2alphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM16426(CHEMBL240714 | Benzeneacetic acid | 2-(2-hydroxyph...)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of [3H]NCS-382 binding to CaMK2alpha in rat cerebrocortical membranesMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM6838(1-(2-{18-methyl-12,14-dioxo-3,13,18-triazahexacycl...)
Affinity DataIC50: 25nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50430016(CHEMBL2335444)
Affinity DataIC50: 30nMAssay Description:Inhibition of recombinant full length CAMK2alpha (unknown origin) using autocamtide-2 as substrate assessed as incorporation of 32P after 30 mins by ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50430015(CHEMBL2335442)
Affinity DataIC50: 40nMAssay Description:Inhibition of recombinant full length CAMK2alpha (unknown origin) using autocamtide-2 as substrate assessed as incorporation of 32P after 30 mins by ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM6840(5-[2-(4-hydroxypiperidin-1-yl)ethyl]-18-methyl-3,1...)
Affinity DataIC50: 46nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM6846(5-{2-[(4-hydroxycyclohexyl)amino]ethyl}-18-methyl-...)
Affinity DataIC50: 49nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50430014(CHEMBL2335479)
Affinity DataIC50: 50nMAssay Description:Inhibition of recombinant full length CAMK2alpha (unknown origin) using autocamtide-2 as substrate assessed as incorporation of 32P after 30 mins by ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM6858(8-bromo-3,13,23-triazahexacyclo[14.7.0.0^{2,10}.0^...)
Affinity DataIC50: 58nMT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM6842(18-methyl-5-[2-(piperidin-1-yl)ethyl]-3,13,18-tria...)
Affinity DataIC50: 62nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM6837(methyl 1-(2-{18-methyl-12,14-dioxo-3,13,18-triazah...)
Affinity DataIC50: 81nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM6864(6-methyl-3,13,23-triazahexacyclo[14.7.0.0^{2,10}.0...)
Affinity DataIC50: 82nMT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM6841(5-{2-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]ethyl}...)
Affinity DataIC50: 90nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM6862(6-fluoro-3,13,23-triazahexacyclo[14.7.0.0^{2,10}.0...)
Affinity DataIC50: 92nM EC50:  40nMT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM6843(5-{2-[(2-hydroxyethyl)amino]ethyl}-18-methyl-3,13,...)
Affinity DataIC50: 95nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM2672(6,7,12,13-Tetrahydro-5,7-dioxo-5H-indolo[2,3-a]pyr...)
Affinity DataIC50: 125nMT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]A...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM6768(indolocarbazole deriv. 4(f) | 20-bromo-3-methyl-3,...)
Affinity DataIC50: 174nM EC50:  80nMT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM6850(5-[3-(diethylamino)propyl]-18-methyl-3,13,18-triaz...)
Affinity DataIC50: 174nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM6844(18-methyl-5-[2-(morpholin-4-yl)ethyl]-3,13,18-tria...)
Affinity DataIC50: 177nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM6851(5-{3-[(4-hydroxycyclohexyl)amino]propyl}-18-methyl...)
Affinity DataIC50: 216nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM6856(6-methoxy-3,13,23-triazahexacyclo[14.7.0.0^{2,10}....)
Affinity DataIC50: 236nMT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM6848(5-{3-[(2-hydroxyethyl)amino]propyl}-18-methyl-3,13...)
Affinity DataIC50: 266nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50163748(4-(2-(5-(4-hydroxy-3-methoxystyryl)-1H-pyrazol-3-y...)
Affinity DataIC50: 290nMAssay Description:Inhibition of autophosphorylated alphaCaMK2 using GST-NR2A as substrate incubated for 1 min prior to substrate addition measured after 1 min in prese...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM6839(18-methyl-5-[2-(piperazin-1-yl)ethyl]-3,13,18-tria...)
Affinity DataIC50: 301nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM6847(18-methyl-5-[3-(4-methylpiperazin-1-yl)propyl]-3,1...)
Affinity DataIC50: 382nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM6845(18-methyl-5-[2-(thiomorpholin-4-yl)ethyl]-3,13,18-...)
Affinity DataIC50: 403nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM6849(18-methyl-5-[3-(morpholin-4-yl)propyl]-3,13,18-tri...)
Affinity DataIC50: 516nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM6829(3-{2-[(2-hydroxyethyl)amino]ethyl}-6-methoxy-18-me...)
Affinity DataIC50: 527nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50163745(4-((E)-2-{3-[(E)-2-(4-hydroxy-3-methoxyphenyl)viny...)
Affinity DataIC50: 680nMAssay Description:Inhibition of autophosphorylated alphaCaMK2 using GST-NR2A as substrate incubated for 1 min prior to substrate addition measured after 1 min in prese...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM6834(3-{3-[(2-hydroxyethyl)amino]propyl}-6-methoxy-18-m...)
Affinity DataIC50: 732nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50520464(CHEMBL4556306)
Affinity DataIC50: 790nMAssay Description:Inhibition of human CaMKIIalpha using calmodulin and syntide-2 incubated for 15 mins by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50520463(CHEMBL4572769)
Affinity DataIC50: 810nMAssay Description:Inhibition of human CaMKIIalpha using calmodulin and syntide-2 incubated for 15 mins by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50520462(CHEMBL4515601)
Affinity DataIC50: 840nMAssay Description:Inhibition of human CaMKIIalpha using calmodulin and syntide-2 incubated for 15 mins by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM6854(6-chloro-3,13,23-triazahexacyclo[14.7.0.0^{2,10}.0...)
Affinity DataIC50: 914nMT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50095952(CHEMBL3593777)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of CaMK2a (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50611755(CHEMBL5281283)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of CAMK2alpha (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50087267((S)-4-(2-(N-methylisoquinoline-5-sulfonamido)-3-ox...)
Affinity DataIC50: 1.03E+3nMAssay Description:Inhibition of human CaMKIIalpha using calmodulin and syntide-2 incubated for 15 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM6830(3-{2-[(4-hydroxycyclohexyl)amino]ethyl}-6-methoxy-...)
Affinity DataIC50: 1.17E+3nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM6859(7-bromo-3,13,23-triazahexacyclo[14.7.0.0^{2,10}.0^...)
Affinity DataIC50: 1.25E+3nM EC50:  70nMT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50163748(4-(2-(5-(4-hydroxy-3-methoxystyryl)-1H-pyrazol-3-y...)
Affinity DataIC50: 1.49E+3nMAssay Description:Inhibition of alphaCaMK2 using GST-NR2A as substrate incubated for 1 min prior to substrate addition measured after 1 minMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50228744(CHEBI:59612 | 5-Hydroxy-Diclofenac)
Affinity DataIC50: 1.81E+3nMAssay Description:Binding affinity to recombinant human CaMK2alpha 6x hub domain (345 to 475 residues) Trp403 residue assessed as inhibition of intrinsic tryptophan fl...More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM6766(indolocarbazole deriv. 4(h) | 20-fluoro-3-methyl-3...)
Affinity DataIC50: 2.00E+3nMT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM6855(6-(trifluoromethyl)-3,13,23-triazahexacyclo[14.7.0...)
Affinity DataIC50: 2.00E+3nMT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM6857(6-bromo-20-methoxy-3,13,23-triazahexacyclo[14.7.0....)
Affinity DataIC50: 2.00E+3nMT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50563780(CHEMBL4795714)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of wild-type human CAMK2alpha using KKALRRQETVDAL peptide as substrate in presence of Ca2+ calmodulin and [gamma-33P]-ATP by radiometric h...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM6831(1-(3-{6-methoxy-18-methyl-12,14-dioxo-3,13,18-tria...)
Affinity DataIC50: 3.05E+3nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM6832(3-[3-(4-hydroxypiperidin-1-yl)propyl]-6-methoxy-18...)
Affinity DataIC50: 3.13E+3nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
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