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TargetSerine/threonine-protein kinase PAK 2(Human)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 1nMAssay Description:Inhibition of PAK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human PAK2 using RRRLSFAEPG as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of PAK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of human PAK2 using RRRLSFAEPG as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50201641(CHEMBL3923175)
Affinity DataIC50: 6nMAssay Description:Inhibition of N-terminal 6His-tagged recombinant human PAK2 (3-end residues) expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50148921(CHEMBL3770443)
Affinity DataIC50: 11nMAssay Description:Inhibition of human recombinant PAK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50112347(CHEMBL3609327 | FRAX597)
Affinity DataIC50: 12.8nMAssay Description:IC50 values were determined using a 10 concentration point, non-radioactive, functional assay that employs a fluorescence-based, coupled enzyme forma...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase PAK 2(Human)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50112347(CHEMBL3609327 | FRAX597)
Affinity DataIC50: 13nMAssay Description:Inhibition of recombinant human PAK2 by Z'-LYTE assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase PAK 2(Human)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50112347(CHEMBL3609327 | FRAX597)
Affinity DataIC50: 19nMAssay Description:Inhibition of PAK2 (unknown origin) using lipid substrate measured after 40 mins by ADP-glo kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase PAK 2(Human)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50112355(CHEMBL3609326)
Affinity DataIC50: 40nMAssay Description:Inhibition of full length PAK2 (unknown origin) by Z'-LYTE assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50601538(CHEMBL5090394)
Affinity DataIC50: 41nMAssay Description:Inhibition of human PAK2 by radiometric PanQinase activity assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50434330(CHEMBL2386715)
Affinity DataIC50: 64nMAssay Description:Inhibition of PAK2-mediated MEK1 phosphorylation at Ser298 in human EBC1 cells after 2 hrs by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50434331(CHEMBL2386717)
Affinity DataIC50: 71nMAssay Description:Inhibition of PAK2-mediated MEK1 phosphorylation at Ser298 in human EBC1 cells after 2 hrs by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50434332(CHEMBL2386716)
Affinity DataIC50: 133nMAssay Description:Inhibition of PAK2-mediated MEK1 phosphorylation at Ser298 in human EBC1 cells after 2 hrs by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM101618(US8530652, 114)
Affinity DataIC50: 190nMAssay Description:Inhibition of PAK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase PAK 2(Human)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50434333(CHEMBL2386718)
Affinity DataIC50: 244nMAssay Description:Inhibition of PAK2-mediated MEK1 phosphorylation at Ser298 in human EBC1 cells after 2 hrs by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50609598(CHEMBL5274607)
Affinity DataIC50: 824nMAssay Description:Inhibition of human recombinant full length PAK2 assessed as phosphorylation FRET peptide substrate measured after 60 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50448771(CHEMBL3128042)
Affinity DataIC50: 970nMAssay Description:Inhibition of PAK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50462709(CHEMBL4245507)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PAK2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50192071((13R,15S)-13-methyl-16-oxa-8,9,12,22,24-pentaazahe...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PAK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50564348(CHEMBL4780410)
Affinity DataIC50: 1.04E+3nMAssay Description:Inhibition of PAK2 (unknown origin) using lipid substrate measured after 40 mins by ADP-glo kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM106870(US8592455, 70)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PAK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50429477(CHEMBL2332840)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PAK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50609599(CHEMBL5281068)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant full length PAK2 assessed as phosphorylation FRET peptide substrate measured after 60 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50501882(CHEMBL4446361)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of wild-type human partial length PAK2 (P151 to R525 residues) expressed in bacterial expression system after 1 hr by Z-LYTE assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50436850(CHEMBL2403108 | CERITINIB | US10053458, Comparativ...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PAK2 (unknown origin) after 60 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50363167(CHEMBL1945559)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PAK2 using ATP as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50355393(CHEMBL1834657 | US9434697, BGJ398 | US9730931, BGJ...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant PAK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50135286(CHEMBL3745885)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human PAK2 using [KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK] substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50123803(CHEMBL3623375)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant PAK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50001733(CHEMBL3133821)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human PAK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM236557(US9365572, 5)
Affinity DataIC50: 1.00E+4nMpH: 7.5 T: 2°CAssay Description:Agents: 1-fold kinase buffer without MnCl2: 50 mM HEPES, pH 7.5, 0.0015% Brij-35, 10 mM MgCl2, 2 mM DTT. 1-fold kinase buffer with MnCl2: 50 mM HEPES...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase PAK 2(Human)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50194668(4-methyl-3-(2-(2-morpholinoethylamino)quinazolin-6...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of Pak2 by HTRF kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50194671(4-methyl-3-(2-(methylamino)quinazolin-6-yl)-N-(2-(...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of Pak2 by HTRF kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM13533(1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PAK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50359359(CHEMBL1929238)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PAK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PAK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50537742(CHEMBL4634634 | US11179389, Compound 1-14)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant full length human GST-tagged PAK2 expressed in baculovirus expression system using serine/threonine-20 peptide as substrate...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase PAK 2(Human)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50038423(CHEMBL3361128)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant PAK2 (unknown origin) after 60 mins by z'-lyte kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed