Compile Data Set for Download or QSAR
Report error Found 2598 of ic50 data for polymerid = 8450,50001338,50002198,50007583
LigandPNGBDBM50009832(CHEMBL269550 | 1-Benzyl-4-hydroxy-5-oxo-2,5-dihydr...)
Affinity DataIC50: 0.420nMAssay Description:Inhibitory activity was measured against rat lens aldose reductase in the presence of 1 uM compound with D-glucose as substratesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50009832(CHEMBL269550 | 1-Benzyl-4-hydroxy-5-oxo-2,5-dihydr...)
Affinity DataIC50: 0.420nMAssay Description:Inhibitory activity was measured against rat lens aldose reductase in the presence of 1 uM compound with D-glucose as substratesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM16315(CP-744809 | CHEMBL240725 | 6-[(5-chloro-3-methyl-1...)
Affinity DataIC50: 0.840nMpH: 7.0 T: 2°CAssay Description:The activity of the enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappearance ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM16315(CP-744809 | CHEMBL240725 | 6-[(5-chloro-3-methyl-1...)
Affinity DataIC50: 0.840nMAssay Description:Inhibition of Homo sapiens (human) recombinant aldose reductase using D-glyceraldehyde as substrate incubated for 10 min prior to substrate addition ...More data for this Ligand-Target Pair
In DepthDetails Article
PDB3D3D Structure (crystal)
LigandPNGBDBM16315(CP-744809 | CHEMBL240725 | 6-[(5-chloro-3-methyl-1...)
Affinity DataIC50: 1nMAssay Description:The activity of the enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappearance ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM16314(N-{[6-methoxy-5-(trifluoromethyl)naphthalen-1-yl]c...)
Affinity DataIC50: 1nMpH: 7.0Assay Description:The IC50-activity assays were carried out on the basis of the quantification of the NADPH consumption that takes place when the enzyme catalyzes the ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50009806(CHEMBL20207 | [3-(7-Chloro-benzothiazol-2-ylmethyl...)
Affinity DataIC50: 1nMAssay Description:Compound was tested for the inhibition of the human placental aldose reductase using the substrate as glyceraldehyde.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM16315(CP-744809 | CHEMBL240725 | 6-[(5-chloro-3-methyl-1...)
Affinity DataIC50: 1nMAssay Description:Inhibition of aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM16315(CP-744809 | CHEMBL240725 | 6-[(5-chloro-3-methyl-1...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant Aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50487936(CHEBI:48480 | CHEMBL2261578)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of Rattus norvegicus (rat) lens aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails Article

LigandPNGBDBM16452((4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-...)
Affinity DataIC50: 1.90nMAssay Description:Compound was tested for the inhibition of the human placental aldose reductase using the substrate as glyceraldehyde.More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM16452((4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-...)
Affinity DataIC50: 1.90nMAssay Description:Compound was tested for the inhibition of the human placental aldose reductase using the substrate as glyceraldehyde.More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50009763(CHEMBL20024 | [3-(4-Fluoro-benzothiazol-2-ylmethyl...)
Affinity DataIC50: 2nMAssay Description:Compound was tested for the inhibition of the human placental aldose reductase using the substrate as glyceraldehyde.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM16314(N-{[6-methoxy-5-(trifluoromethyl)naphthalen-1-yl]c...)
Affinity DataIC50: 2nMAssay Description:In vitro inhibition of Aldose reductase (AR) from rat lens (RL)More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50006469(CHEMBL69956 | [8-Oxo-7-(5-trifluoromethyl-benzothi...)
Affinity DataIC50: 2.10nMAssay Description:Inhibitory activity against aldose reductase isolated from human placentaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM16452((4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-...)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of human placenta Aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50006469(CHEMBL69956 | [8-Oxo-7-(5-trifluoromethyl-benzothi...)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of human Aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50122956([2,4-Bis-(4-methoxy-benzoyl)-pyrrol-1-yl]-acetic a...)
Affinity DataIC50: 2.36nMAssay Description:Inhibitory activity against aldose reductase enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50122956([2,4-Bis-(4-methoxy-benzoyl)-pyrrol-1-yl]-acetic a...)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of ALR in Fischer-344 rat lens using D,L-glyceraldehyde as substrate in presence of NADPH measured after 3 mins by spectrophotometric assa...More data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM16633(6-[(5-fluoro-3-methyl-1-benzofuran-2-)sulfonyl]-2,...)
Affinity DataIC50: 3nMAssay Description:The activity of the enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappearance ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM16313(IDD594 | LdT | CHEMBL395347 | {2-[(4-bromo-2-fluor...)
Affinity DataIC50: 3nMpH: 7.0Assay Description:The IC50-activity assays were carried out on the basis of the quantification of the NADPH consumption that takes place when the enzyme catalyzes the ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM16314(N-{[6-methoxy-5-(trifluoromethyl)naphthalen-1-yl]c...)
Affinity DataIC50: 3nMAssay Description:Inhibitory activity measured against rat lens aldose reductase using 3-pyridinecarboxaldehyde as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM16452((4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-...)
Affinity DataIC50: 3.10nMAssay Description:In vitro inhibitory activity against aldose reductase isolated from human placentaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50009781(CHEMBL20169 | [3-(5-Bromo-benzothiazol-2-ylmethyl)...)
Affinity DataIC50: 3.10nMAssay Description:Compound was tested for the inhibition of the human placental aldose reductase using the substrate as glyceraldehyde.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50009767(2-(4-oxo-3-((6-(trifluoromethyl)benzo[d]thiazol-2-...)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM16452((4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-...)
Affinity DataIC50: 3.10nMAssay Description:Inhibitory activity against aldose reductase enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM16452((4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-...)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of aldose reductase (aldo-keto reductase, AKR1B1) isolated from human placenta.More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM16452((4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-...)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of human placental aldose reductase using glyceraldehyde as substrate in presence of NADPHMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50009781(CHEMBL20169 | [3-(5-Bromo-benzothiazol-2-ylmethyl)...)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of human placenta Aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50008471(CHEMBL143234 | [3-(5,7-Difluoro-benzooxazol-2-ylme...)
Affinity DataIC50: 3.20nMAssay Description:In vitro inhibitory activity against aldose reductase isolated from human placentaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50006481(CHEMBL73560 | [1-(5,7-Difluoro-benzothiazol-2-ylme...)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of human Aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50008471(CHEMBL143234 | [3-(5,7-Difluoro-benzooxazol-2-ylme...)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of human placenta Aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50006475(CHEMBL71966 | {1-[3-(2,3-Difluoro-phenyl)-[1,2,4]o...)
Affinity DataIC50: 3.30nMAssay Description:Inhibitory activity against aldose reductase isolated from human placentaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50009828(CHEMBL20015 | [3-(4-Chloro-benzothiazol-2-ylmethyl...)
Affinity DataIC50: 3.5nMAssay Description:Compound was tested for the inhibition of the human placental aldose reductase using the substrate as glyceraldehyde.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM16452((4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-...)
Affinity DataIC50: 4nMpH: 7.0 T: 2°CAssay Description:The activity of the enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappearance ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50006459(CHEMBL304995 | [3-(5,7-Difluoro-benzothiazol-2-ylm...)
Affinity DataIC50: 4nMAssay Description:Inhibitory activity against aldose reductase isolated from human placentaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50009784(CHEMBL278991 | [3-(5,7-Dichloro-benzothiazol-2-ylm...)
Affinity DataIC50: 4nMAssay Description:Compound was tested for the inhibition of the human placental aldose reductase using the substrate as glyceraldehyde.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50487916(CHEMBL2261575)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of Rattus norvegicus (rat) lens aldose reductaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article

LigandPNGBDBM16496(CHEMBL10413 | FR 74366 | [3-(4-bromo-2-fluorobenzy...)
Affinity DataIC50: 4.40nMAssay Description:Inhibitory activity against purified rat lens aldose reductase (RLAR)More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50006470(CHEMBL73505 | [5-Chloro-1-(5-fluoro-benzothiazol-2...)
Affinity DataIC50: 4.60nMAssay Description:Inhibitory activity against aldose reductase isolated from human placentaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM16452((4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-...)
Affinity DataIC50: 4.80nMAssay Description:Inhibitory activity against aldose reductase isolated from human placentaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM16634(6-{[3-methyl-5-(trifluoromethyl)-1-benzofuran-2-]s...)
Affinity DataIC50: 5nMAssay Description:The activity of the enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappearance ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM16469(Indoleacetic Acid Inhibitor 9 | 2-{3-[(4,5,7-trifl...)
Affinity DataIC50: 5nMpH: 6.6 T: 2°CAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM16485(2-{6-methoxy-3-[(4,5,7-trifluoro-1,3-benzothiazol-...)
Affinity DataIC50: 5nMAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50006481(CHEMBL73560 | [1-(5,7-Difluoro-benzothiazol-2-ylme...)
Affinity DataIC50: 5nMAssay Description:Inhibitory activity against aldose reductase isolated from human placentaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50009750(CHEMBL282689 | [3-(4,7-Difluoro-benzothiazol-2-ylm...)
Affinity DataIC50: 5nMAssay Description:Compound was tested for the inhibition of the human placental aldose reductase using the substrate as glyceraldehyde.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50009759(CHEMBL20518 | [3-(5-Chloro-7-fluoro-benzothiazol-2...)
Affinity DataIC50: 5nMAssay Description:Compound was tested for the inhibition of the human placental aldose reductase using the substrate as glyceraldehyde.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM16469(Indoleacetic Acid Inhibitor 9 | 2-{3-[(4,5,7-trifl...)
Affinity DataIC50: 5nMAssay Description:Inhibition of Wistar rat lens aldose reductase using D,L-glyceraldehyde as substrate incubated for 1 min measured for 4 mins by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM16452((4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-...)
Affinity DataIC50: 5nMAssay Description:Inhibition of Wistar rat lens aldose reductase using D,L-glyceraldehyde as substrate incubated for 1 min measured for 4 mins by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM16469(Indoleacetic Acid Inhibitor 9 | 2-{3-[(4,5,7-trifl...)
Affinity DataIC50: 5nMAssay Description:Inhibition of aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
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