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TargetLysine-specific demethylase 6A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50158859(CHEMBL3787193)
Affinity DataIC50: 100nMAssay Description:Inhibition of KDM6A (919 to 1401 residues) (unknown origin) expressed in Escherichia coli using biotinylated histone H3 as substrate preincubated for...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 6A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM191599(KDOAM-21 | ethyl 2-(((2-((2-(dimethylamino)ethyl)(...)
Affinity DataIC50: 100nMAssay Description:Inhibition of KDM6A (919 to 1401 residues) (unknown origin) expressed in Escherichia coli using biotinylated histone H3 as substrate preincubated for...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 6A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50396018(CHEMBL1230640)
Affinity DataIC50: 200nMAssay Description:Inhibition of KDM6A (unknown origin) expressed in Escherichia coli using Biotin-H3(14-34)K27me3 peptide and measured after 1 hrs by alpha screen assa...More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific demethylase 6A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM191598(KDOAM-20 | KDM5-C49 | 2-(((2-((2-(dimethylamino)et...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of KDM6A (919 to 1401 residues) (unknown origin) expressed in Escherichia coli using biotinylated histone H3 as substrate preincubated for...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 6A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50158860(CHEMBL3785378)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of KDM6A (919 to 1401 residues) (unknown origin) expressed in Escherichia coli using biotinylated histone H3 as substrate preincubated for...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 6A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50155449(CHEMBL3780958)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of human KDM6A preincubated for 10 mins followed by substrate addition by AlphaLISA assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 6A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50155450(CHEMBL3779953)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of human KDM6A preincubated for 10 mins followed by substrate addition by AlphaLISA assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 6A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50155505(CHEMBL3781414)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of human KDM6A preincubated for 10 mins followed by substrate addition by AlphaLISA assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 6A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50155507(CHEMBL3780904)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of human KDM6A preincubated for 10 mins followed by substrate addition by AlphaLISA assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 6A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50155508(CHEMBL3780833)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of human KDM6A preincubated for 10 mins followed by substrate addition by AlphaLISA assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 6A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50155509(CHEMBL3780689)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of human KDM6A preincubated for 10 mins followed by substrate addition by AlphaLISA assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 6A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50158857(CHEMBL3787547)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of KDM6A (919 to 1401 residues) (unknown origin) expressed in Escherichia coli using biotinylated histone H3 as substrate preincubated for...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 6A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50158858(CHEMBL3786409)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of KDM6A (919 to 1401 residues) (unknown origin) expressed in Escherichia coli using biotinylated histone H3 as substrate preincubated for...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 6A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50158861(CHEMBL3786239)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of KDM6A (919 to 1401 residues) (unknown origin) expressed in Escherichia coli using biotinylated histone H3 as substrate preincubated for...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 6A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50158862(CHEMBL3786275)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of KDM6A (919 to 1401 residues) (unknown origin) expressed in Escherichia coli using biotinylated histone H3 as substrate preincubated for...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 6A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM60875(GSK-J1 | 3-((6-(4,5-Dihydro-1H-benzo[d]azepin-3(2H...)
Affinity DataIC50: 3.20E+3nMAssay Description:TR-FRET assays similar to those described above for KDM5 enzymes were carried out with full-length KDM2B, KDM3B, KDM4C, KDM6A and KDM7B.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 6A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50525976(CHEBI:68554 | APO-066 | APO-66 | CP-20 | CP20 | DN...)
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of KDM6A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific demethylase 6A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50609282(CHEMBL5274906)
Affinity DataIC50: 6.60E+3nMAssay Description:Inhibition of KDM6A (unknown origin ) by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetLysine-specific demethylase 6A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM281089(US10022354, Example 29)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged KDM6A expressed in baculovirus infected Sf9 insect cells using H3K27me3 peptide as substrate a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 6A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM281138(US10022354, Example 78)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged KDM6A expressed in baculovirus infected Sf9 insect cells using H3K27me3 peptide as substrate a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 6A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM195609(CPI-4203)
Affinity DataIC50: 2.50E+4nMAssay Description:TR-FRET assays similar to those described above for KDM5 enzymes were carried out with full-length KDM2B, KDM3B, KDM4C, KDM6A and KDM7B.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 6A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM195608(CPI-455 | US20240139197, Compound 3)
Affinity DataIC50: 2.50E+4nMAssay Description:TR-FRET assays similar to those described above for KDM5 enzymes were carried out with full-length KDM2B, KDM3B, KDM4C, KDM6A and KDM7B.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 6A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50535443(CHEMBL4591907)
Affinity DataIC50: 2.57E+4nMAssay Description:Inhibition of UTX (unknown origin) using histone H3 peptide as substrate incubated for 30 mins followed by substrate addition by AlphaScreen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 6A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50574750(CHEMBL4850758)
Affinity DataIC50: 3.71E+4nMAssay Description:Inhibition of KDM6A (unknown origin) by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 6A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50468052(CHEMBL4283844)
Affinity DataIC50: 3.90E+4nMAssay Description:Inhibition of KDM6A (880 to 1401 residues) (unknown origin) using H3 ( 21 to 44 residues) K27me3 as substrate preincubated for 15 min followed by sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 6A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50468053(CHEMBL4294426)
Affinity DataIC50: 5.50E+4nMAssay Description:Inhibition of KDM6A (880 to 1401 residues) (unknown origin) using H3 ( 21 to 44 residues) K27me3 as substrate preincubated for 15 min followed by sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 6A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM60875(GSK-J1 | 3-((6-(4,5-Dihydro-1H-benzo[d]azepin-3(2H...)
Affinity DataIC50: 6.90E+4nMAssay Description:Inhibition of KDM6A (880 to 1401 residues) (unknown origin) using H3 ( 21 to 44 residues) K27me3 as substrate preincubated for 15 min followed by sub...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 6A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50440287(CHEMBL2424814)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant KDM6A after 1 hrMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 6A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50395076(CHEMBL2164243)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant KDM6A after 1 hrMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 6A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50440292(CHEMBL2424809)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant KDM6A after 1 hrMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 6A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50440291(CHEMBL2424810)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant KDM6A after 1 hrMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 6A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50440290(CHEMBL2424811)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant KDM6A after 1 hrMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 6A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50440289(CHEMBL2424812)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant KDM6A after 1 hrMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 6A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50440288(CHEMBL2424813)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant KDM6A after 1 hrMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 6A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50440286(CHEMBL2424815)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant KDM6A after 1 hrMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 6A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50440285(CHEMBL2424816)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant KDM6A after 1 hrMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine-specific demethylase 6A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataIC50: 1.64E+5nMAssay Description:Inhibition of recombinant UTX (unknown origin) using H3(17-44)K27me3 as substrate preincubated with compound for 30 mins followed by substrate additi...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetLysine-specific demethylase 6A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM26113(pyridine-2,4-dicarboxylic acid | cid_10365 | pyrid...)
Affinity DataIC50: 1.77E+5nMAssay Description:Inhibition of KDM6AMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed