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TargetKinase suppressor of Ras 2(Human)
Icahn School of Medicine At Mount Sinai

US Patent
LigandPNGBDBM429286(APS-2-79 | US10548897, Compound 21)
Affinity DataIC50: 120nMAssay Description:The ATP-biotin assay was performed in buffer containing 25 mM Tris pH 7.5, 150 mM NaCl, 10 mM MgCl2, and 2% DMSO. Purified hKSR2-rMEK1 was assayed at...More data for this Ligand-Target Pair
In DepthDetails
US Patent
PDB3D3D Structure (crystal)
TargetKinase suppressor of Ras 2(Human)
Icahn School of Medicine At Mount Sinai

US Patent
LigandPNGBDBM50095227((6,7-Dimethoxy-quinazolin-4-yl)-(4-phenoxy-phenyl)...)
Affinity DataIC50: 602nMAssay Description:The ATP-biotin assay was performed in buffer containing 25 mM Tris pH 7.5, 150 mM NaCl, 10 mM MgCl2, and 2% DMSO. Purified hKSR2-rMEK1 was assayed at...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetKinase suppressor of Ras 2(Human)
Icahn School of Medicine At Mount Sinai

US Patent
LigandPNGBDBM429418(APS-2-12 | US10548897, Compound 10)
Affinity DataIC50: 1.50E+3nMAssay Description:The ATP-biotin assay was performed in buffer containing 25 mM Tris pH 7.5, 150 mM NaCl, 10 mM MgCl2, and 2% DMSO. Purified hKSR2-rMEK1 was assayed at...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetKinase suppressor of Ras 2(Human)
Icahn School of Medicine At Mount Sinai

US Patent
LigandPNGBDBM429420(APS-2-16 | US10548897, Compound 11 | D3RKN_87)
Affinity DataIC50: 2.50E+3nMAssay Description:The ATP-biotin assay was performed in buffer containing 25 mM Tris pH 7.5, 150 mM NaCl, 10 mM MgCl2, and 2% DMSO. Purified hKSR2-rMEK1 was assayed at...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetKinase suppressor of Ras 2(Human)
Icahn School of Medicine At Mount Sinai

US Patent
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 3.98E+3nMAssay Description:Inhibition of human KSR2 using KRREILSRRPSYR as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetKinase suppressor of Ras 2(Human)
Icahn School of Medicine At Mount Sinai

US Patent
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 6.82E+3nMAssay Description:Inhibition of human KSR2 using KRREILSRRPSYR as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetKinase suppressor of Ras 2(Human)
Icahn School of Medicine At Mount Sinai

US Patent
LigandPNGBDBM429415(APS-3-77 | US10548897, Compound 50)
Affinity DataIC50: 1.00E+4nMAssay Description:The ATP-biotin assay was performed in buffer containing 25 mM Tris pH 7.5, 150 mM NaCl, 10 mM MgCl2, and 2% DMSO. Purified hKSR2-rMEK1 was assayed at...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetKinase suppressor of Ras 2(Human)
Icahn School of Medicine At Mount Sinai

US Patent
LigandPNGBDBM50227519(CHEMBL405130 | CHEMBL555201 | 4-(6,7-dimethoxyquin...)
Affinity DataIC50: 1.00E+4nMAssay Description:The ATP-biotin assay was performed in buffer containing 25 mM Tris pH 7.5, 150 mM NaCl, 10 mM MgCl2, and 2% DMSO. Purified hKSR2-rMEK1 was assayed at...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetKinase suppressor of Ras 2(Human)
Icahn School of Medicine At Mount Sinai

US Patent
LigandPNGBDBM50291090(CHEMBL1191611 | CHEMBL542733 | (6,7-Dimethoxy-quin...)
Affinity DataIC50: 1.00E+4nMAssay Description:The ATP-biotin assay was performed in buffer containing 25 mM Tris pH 7.5, 150 mM NaCl, 10 mM MgCl2, and 2% DMSO. Purified hKSR2-rMEK1 was assayed at...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetKinase suppressor of Ras 2(Human)
Icahn School of Medicine At Mount Sinai

US Patent
LigandPNGBDBM429421(APS-3-6 | US10548897, Compound 32)
Affinity DataIC50: 1.00E+4nMAssay Description:The ATP-biotin assay was performed in buffer containing 25 mM Tris pH 7.5, 150 mM NaCl, 10 mM MgCl2, and 2% DMSO. Purified hKSR2-rMEK1 was assayed at...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent