Compile Data Set for Download or QSAR
Report error Found 782 of ic50 data for polymerid = 7603
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
Centre Hospitalier Universitaire Vaudois (Chuv)

Curated by ChEMBL
LigandPNGBDBM50533418(CHEMBL4435465)
Affinity DataIC50: 5.30nMAssay Description:Inhibition of ADAM10 (unknown origin) assessed as blockage of TNF-alpha sheddingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
Centre Hospitalier Universitaire Vaudois (Chuv)

Curated by ChEMBL
LigandPNGBDBM50601784(CHEMBL5206579)
Affinity DataIC50: 5.30nMAssay Description:Inhibition of human ADAM10 using (biotin-SPLAQAVRSSSRTP(3H)S-NH2) as a substrate by streptavidin-coated scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
Centre Hospitalier Universitaire Vaudois (Chuv)

Curated by ChEMBL
LigandPNGBDBM50229655(trans-2-hydroxycyclopentyl 4-(hydroxycarbamoyl)-4-...)
Affinity DataIC50: 6.20nMAssay Description:Inhibition of HER2 sheddase in human BT474 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
Centre Hospitalier Universitaire Vaudois (Chuv)

Curated by ChEMBL
LigandPNGBDBM50229651((S)-pyrrolidin-2-ylmethyl 4-((4-(4-cyano-2-methylp...)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of HER2 sheddase in human BT474 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
Centre Hospitalier Universitaire Vaudois (Chuv)

Curated by ChEMBL
LigandPNGBDBM50229639((S)-tetrahydrofuran-3-yl 4-(hydroxycarbamoyl)-4-((...)
Affinity DataIC50: 7.10nMAssay Description:Inhibition of HER2 sheddase in human BT474 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
Centre Hospitalier Universitaire Vaudois (Chuv)

Curated by ChEMBL
LigandPNGBDBM50229641(pyrrolidin-3-yl 4-((4-(4-cyano-2-methylphenyl)pipe...)
Affinity DataIC50: 7.80nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
Centre Hospitalier Universitaire Vaudois (Chuv)

Curated by ChEMBL
LigandPNGBDBM50062351((R)-N*4*-Hydroxy-N*1*-[2-(1H-indol-3-yl)-1-methylc...)
Affinity DataIC50: 8.10nMAssay Description:In vitro inhibition of A disintegrin and metalloprotease domain 10 (ADAM10)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
Centre Hospitalier Universitaire Vaudois (Chuv)

Curated by ChEMBL
LigandPNGBDBM50301104((5S,6S)-5-(hydroxycarbamoyl)-6-(4-phenyl-1,2,3,6-t...)
Affinity DataIC50: 9nMAssay Description:Inhibition of ADAM-10More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
Centre Hospitalier Universitaire Vaudois (Chuv)

Curated by ChEMBL
LigandPNGBDBM50229651((S)-pyrrolidin-2-ylmethyl 4-((4-(4-cyano-2-methylp...)
Affinity DataIC50: 9.10nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
Centre Hospitalier Universitaire Vaudois (Chuv)

Curated by ChEMBL
LigandPNGBDBM50151244(CHEMBL3770688)
Affinity DataIC50: 9.20nMAssay Description:Inhibition of recombinant human ADAM-10 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate after 1 hr by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
Centre Hospitalier Universitaire Vaudois (Chuv)

Curated by ChEMBL
LigandPNGBDBM50301118((3S,5S,6S)-5-(hydroxycarbamoyl)-1-methyl-6-(4-phen...)
Affinity DataIC50: 9.60nMAssay Description:Inhibition of ADAM-10More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
Centre Hospitalier Universitaire Vaudois (Chuv)

Curated by ChEMBL
LigandPNGBDBM50229639((S)-tetrahydrofuran-3-yl 4-(hydroxycarbamoyl)-4-((...)
Affinity DataIC50: 10nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
Centre Hospitalier Universitaire Vaudois (Chuv)

Curated by ChEMBL
LigandPNGBDBM50229636((R)-pyrrolidin-2-ylmethyl 4-((4-(4-cyano-2-methylp...)
Affinity DataIC50: 11nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
Centre Hospitalier Universitaire Vaudois (Chuv)

Curated by ChEMBL
LigandPNGBDBM50229660(3-methyl-tetrahydrofuran-3-yl 4-(hydroxycarbamoyl)...)
Affinity DataIC50: 11nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
Centre Hospitalier Universitaire Vaudois (Chuv)

Curated by ChEMBL
LigandPNGBDBM50301107(isopropyl-(5S,6S)-5-(hydroxycarbamoyl)-6-(4-phenyl...)
Affinity DataIC50: 11nMAssay Description:Inhibition of ADAM-10More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
Centre Hospitalier Universitaire Vaudois (Chuv)

Curated by ChEMBL
LigandPNGBDBM50301109((5S,6S)-5-(hydroxycarbamoyl)-6-(4-phenylpiperazine...)
Affinity DataIC50: 11nMAssay Description:Inhibition of ADAM-10More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
Centre Hospitalier Universitaire Vaudois (Chuv)

Curated by ChEMBL
LigandPNGBDBM50229643((S)-tetrahydrofuran-3-yl 4-((4-(4-cyano-2-methylph...)
Affinity DataIC50: 12nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
Centre Hospitalier Universitaire Vaudois (Chuv)

Curated by ChEMBL
LigandPNGBDBM50301106((2S,3S)-N-hydroxy-5-(N-methylbenzamido)-2-(4-pheny...)
Affinity DataIC50: 12nMAssay Description:Inhibition of ADAM-10More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
Centre Hospitalier Universitaire Vaudois (Chuv)

Curated by ChEMBL
LigandPNGBDBM50203538((6S,7S)-N-hydroxy-6-[(3-phenyl-2,5-dihydro-1H-pyrr...)
Affinity DataIC50: 13nMAssay Description:Inhibition of HER2 sheddase in BT474 cells by extracellular domain shedding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
Centre Hospitalier Universitaire Vaudois (Chuv)

Curated by ChEMBL
LigandPNGBDBM50229641(pyrrolidin-3-yl 4-((4-(4-cyano-2-methylphenyl)pipe...)
Affinity DataIC50: 13nMAssay Description:Inhibition of HER2 sheddase in human BT474 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
Centre Hospitalier Universitaire Vaudois (Chuv)

Curated by ChEMBL
LigandPNGBDBM50229657((S)-tetrahydrofuran-3-yl 4-(hydroxycarbamoyl)-4-((...)
Affinity DataIC50: 13nMAssay Description:Inhibition of HER2 sheddase in human BT474 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
Centre Hospitalier Universitaire Vaudois (Chuv)

Curated by ChEMBL
LigandPNGBDBM50228004((6S,7S)-6-[4-(3-chloro-phenyl)-piperazine-1-carbon...)
Affinity DataIC50: 14nMAssay Description:Binding affinity to ADAM10More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
Centre Hospitalier Universitaire Vaudois (Chuv)

Curated by ChEMBL
LigandPNGBDBM50229643((S)-tetrahydrofuran-3-yl 4-((4-(4-cyano-2-methylph...)
Affinity DataIC50: 14nMAssay Description:Inhibition of HER2 sheddase in human BT474 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
Centre Hospitalier Universitaire Vaudois (Chuv)

Curated by ChEMBL
LigandPNGBDBM50229635(4,4-dimethyl-tetrahydrofuran-3-yl 4-(hydroxycarbam...)
Affinity DataIC50: 14nMAssay Description:Inhibition of HER2 sheddase in human BT474 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
Centre Hospitalier Universitaire Vaudois (Chuv)

Curated by ChEMBL
LigandPNGBDBM50301101((2S,3S)-N-hydroxy-5-(2-oxo-2-(pyrrolidin-1-yl)ethy...)
Affinity DataIC50: 14nMAssay Description:Inhibition of ADAM-10More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
Centre Hospitalier Universitaire Vaudois (Chuv)

Curated by ChEMBL
LigandPNGBDBM50227991((6S,7S)-6-[4-(3,5-difluoro-phenyl)-3,6-dihydro-2H-...)
Affinity DataIC50: 15nMAssay Description:Binding affinity to ADAM10More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
Centre Hospitalier Universitaire Vaudois (Chuv)

Curated by ChEMBL
LigandPNGBDBM50229657((S)-tetrahydrofuran-3-yl 4-(hydroxycarbamoyl)-4-((...)
Affinity DataIC50: 15nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
Centre Hospitalier Universitaire Vaudois (Chuv)

Curated by ChEMBL
LigandPNGBDBM50269057((1S,2S,5S)-N-hydroxy-5-(2-oxo-2-(piperidin-1-yl)et...)
Affinity DataIC50: 15nMAssay Description:Inhibition of human recombinant ADAM10More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
Centre Hospitalier Universitaire Vaudois (Chuv)

Curated by ChEMBL
LigandPNGBDBM50229655(trans-2-hydroxycyclopentyl 4-(hydroxycarbamoyl)-4-...)
Affinity DataIC50: 16nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
Centre Hospitalier Universitaire Vaudois (Chuv)

Curated by ChEMBL
LigandPNGBDBM50227997((6S,7S)-6-[4-(3-isopropyl-phenyl)-piperidine-1-car...)
Affinity DataIC50: 16nMAssay Description:Inhibition of HER2 sheddase in BT474 cells by extracellular domain shedding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
Centre Hospitalier Universitaire Vaudois (Chuv)

Curated by ChEMBL
LigandPNGBDBM50229656(pyrrolidin-3-yl 4-(hydroxycarbamoyl)-4-((4-o-tolyl...)
Affinity DataIC50: 16nMAssay Description:Inhibition of HER2 sheddase in human BT474 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
Centre Hospitalier Universitaire Vaudois (Chuv)

Curated by ChEMBL
LigandPNGBDBM50301103((2S,3S)-N-hydroxy-5-(2-oxo-2-(pyrrolidin-1-yl)ethy...)
Affinity DataIC50: 17nMAssay Description:Inhibition of ADAM-10More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
Centre Hospitalier Universitaire Vaudois (Chuv)

Curated by ChEMBL
LigandPNGBDBM50229656(pyrrolidin-3-yl 4-(hydroxycarbamoyl)-4-((4-o-tolyl...)
Affinity DataIC50: 18nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
Centre Hospitalier Universitaire Vaudois (Chuv)

Curated by ChEMBL
LigandPNGBDBM50203526((6S,7S)-6-(4-phenyl-3,6-dihydro-2H-pyridine-1-carb...)
Affinity DataIC50: 18nMAssay Description:Inhibition of HER2 sheddase in BT474 cells by extracellular domain shedding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
Centre Hospitalier Universitaire Vaudois (Chuv)

Curated by ChEMBL
LigandPNGBDBM50229640((S)-tetrahydrofuran-3-yl 4-(hydroxycarbamoyl)-4-((...)
Affinity DataIC50: 18nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
Centre Hospitalier Universitaire Vaudois (Chuv)

Curated by ChEMBL
LigandPNGBDBM50229650((S)-tetrahydrofuran-3-yl 4-(hydroxycarbamoyl)-4-((...)
Affinity DataIC50: 18nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
Centre Hospitalier Universitaire Vaudois (Chuv)

Curated by ChEMBL
LigandPNGBDBM50301113((3S,5S,6S)-5-(hydroxycarbamoyl)-1-methyl-6-(4-phen...)
Affinity DataIC50: 18nMAssay Description:Inhibition of ADAM-10More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
Centre Hospitalier Universitaire Vaudois (Chuv)

Curated by ChEMBL
LigandPNGBDBM50227989((6S,7S)-7-hydroxycarbamoyl-6-(4-phenyl-piperidine-...)
Affinity DataIC50: 19nMAssay Description:Binding affinity to ADAM10More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
Centre Hospitalier Universitaire Vaudois (Chuv)

Curated by ChEMBL
LigandPNGBDBM50229646((R)-pyrrolidin-2-ylmethyl 4-(hydroxycarbamoyl)-4-(...)
Affinity DataIC50: 19nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
Centre Hospitalier Universitaire Vaudois (Chuv)

Curated by ChEMBL
LigandPNGBDBM50227996((6S,7S)-7-hydroxycarbamoyl-6-(4-phenyl-3,4-dihydro...)
Affinity DataIC50: 19nMAssay Description:Inhibition of HER2 sheddase in BT474 cells by extracellular domain shedding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
Centre Hospitalier Universitaire Vaudois (Chuv)

Curated by ChEMBL
LigandPNGBDBM50229647((R)-pyrrolidin-2-ylmethyl 4-((4-(4-cyano-2-methylp...)
Affinity DataIC50: 19nMAssay Description:Inhibition of HER2 sheddase in human BT474 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
Centre Hospitalier Universitaire Vaudois (Chuv)

Curated by ChEMBL
LigandPNGBDBM50268906((2S,3S,5RS)-N-hydroxy-5-(2-oxo-2-(pyrrolidin-1-yl)...)
Affinity DataIC50: 19nMAssay Description:Inhibition of human recombinant ADAM10More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
Centre Hospitalier Universitaire Vaudois (Chuv)

Curated by ChEMBL
LigandPNGBDBM50301114((2S,3S,5S)-methyl 3-(hydroxycarbamoyl)-2-(4-phenyl...)
Affinity DataIC50: 20nMAssay Description:Inhibition of ADAM-10More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
Centre Hospitalier Universitaire Vaudois (Chuv)

Curated by ChEMBL
LigandPNGBDBM50301102((3S,5S,6S)-5-(hydroxycarbamoyl)-1-methyl-6-(4-phen...)
Affinity DataIC50: 20nMAssay Description:Inhibition of ADAM-10More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
Centre Hospitalier Universitaire Vaudois (Chuv)

Curated by ChEMBL
LigandPNGBDBM50269059((1S,2S,5S)-N-hydroxy-2-(4-(3-isopropylphenyl)piper...)
Affinity DataIC50: 21nMAssay Description:Inhibition of human recombinant ADAM10More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
Centre Hospitalier Universitaire Vaudois (Chuv)

Curated by ChEMBL
LigandPNGBDBM50229644((S)-tetrahydrofuran-3-yl 4-(hydroxycarbamoyl)-4-((...)
Affinity DataIC50: 22nMAssay Description:Inhibition of HER2 sheddase in human BT474 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
Centre Hospitalier Universitaire Vaudois (Chuv)

Curated by ChEMBL
LigandPNGBDBM50203527(methyl (6S,7S)-7-[(hydroxyamino)carbonyl]-6-[(4-ph...)
Affinity DataIC50: 22nMAssay Description:Inhibition of human ADAM10More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
Centre Hospitalier Universitaire Vaudois (Chuv)

Curated by ChEMBL
LigandPNGBDBM50229635(4,4-dimethyl-tetrahydrofuran-3-yl 4-(hydroxycarbam...)
Affinity DataIC50: 22nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
Centre Hospitalier Universitaire Vaudois (Chuv)

Curated by ChEMBL
LigandPNGBDBM50203527(methyl (6S,7S)-7-[(hydroxyamino)carbonyl]-6-[(4-ph...)
Affinity DataIC50: 22nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Human)
Centre Hospitalier Universitaire Vaudois (Chuv)

Curated by ChEMBL
LigandPNGBDBM50332283((R)-5-((6-methoxy-1-oxoisoindolin-2-yl)methyl)-5-(...)
Affinity DataIC50: 22nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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