Compile Data Set for Download or QSAR
Report error Found 341 of ic50 data for polymerid = 7436,50004398,50004485
LigandPNGBDBM50263263(CHEMBL4073443)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of Ser 209 phosphorylation of eIF4E (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50597686(CHEMBL5183975)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of phosphorylation of eIF4E (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
LigandPNGBDBM50263263(CHEMBL4073443)
Affinity DataIC50: 6nMAssay Description:Inhibition of phosphorylation of eIF4E (unknown origin) in HCT-116 cellsMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50565476(CHEMBL4780117)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of recombinant human 10His-tagged eIF4E expressed in Escherichia coli BL21 (DE3) cells by catalytic enzyme-linked click chemistry assayMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50597684(CHEMBL5203720)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of phosphorylation of eIF4E (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
LigandPNGBDBM50597685(CHEMBL5181488)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of phosphorylation of eIF4E (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
LigandPNGBDBM50386777(CHEMBL2046918)
Affinity DataIC50: 16nMAssay Description:Competitive inhibition of [3H]m7-GTP binding to human FLAG-His6 tagged eIF4E expressed in Escherichia coli by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50597682(CHEMBL5206647)
Affinity DataIC50: 16nMAssay Description:Inhibition of phosphorylation of eIF4E (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
LigandPNGBDBM50597673(CHEMBL5175341)
Affinity DataIC50: 20nMAssay Description:Inhibition of eIF4E (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
LigandPNGBDBM50597674(CHEMBL5187414)
Affinity DataIC50: 20nMAssay Description:Inhibition of eIF4E (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
LigandPNGBDBM50597675(CHEMBL5184155)
Affinity DataIC50: 20nMAssay Description:Inhibition of eIF4E (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
LigandPNGBDBM50565475(CHEMBL4777401)
Affinity DataIC50: 22nMAssay Description:Inhibition of recombinant human 10His-tagged eIF4E expressed in Escherichia coli BL21 (DE3) cells by catalytic enzyme-linked click chemistry assayMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50597676(CHEMBL5196084)
Affinity DataIC50: 25nMAssay Description:Inhibition of eIF4E (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
LigandPNGBDBM50597679(CHEMBL5195407)
Affinity DataIC50: 25nMAssay Description:Inhibition of phosphorylation of eIF4E (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
LigandPNGBDBM50597672(CHEMBL5195560)
Affinity DataIC50: 32nMAssay Description:Inhibition of eIF4E (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
LigandPNGBDBM50597683(CHEMBL5171562)
Affinity DataIC50: 32nMAssay Description:Inhibition of phosphorylation of eIF4E (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
LigandPNGBDBM50597687(CHEMBL5180948)
Affinity DataIC50: 32nMAssay Description:Inhibition of phosphorylation of eIF4E (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
LigandPNGBDBM50597671(CHEMBL5186068)
Affinity DataIC50: 40nMAssay Description:Inhibition of eIF4E (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
LigandPNGBDBM50597680(CHEMBL5205835)
Affinity DataIC50: 40nMAssay Description:Inhibition of phosphorylation of eIF4E (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
LigandPNGBDBM50386762(CHEMBL2046906)
Affinity DataIC50: 41nMAssay Description:Competitive inhibition of [3H]m7-GTP binding to human FLAG-His6 tagged eIF4E expressed in Escherichia coli by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50597678(CHEMBL5183411)
Affinity DataIC50: 50nMAssay Description:Inhibition of eIF4E (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
LigandPNGBDBM50386774(CHEMBL2046915)
Affinity DataIC50: 51nMAssay Description:Competitive inhibition of [3H]m7-GTP binding to human FLAG-His6 tagged eIF4E expressed in Escherichia coli by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50386769(CHEMBL2046910)
Affinity DataIC50: 56nMAssay Description:Competitive inhibition of [3H]m7-GTP binding to human FLAG-His6 tagged eIF4E expressed in Escherichia coli by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50386766(CHEMBL2046905)
Affinity DataIC50: 59nMAssay Description:Competitive inhibition of [3H]m7-GTP binding to human FLAG-His6 tagged eIF4E expressed in Escherichia coli by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50525088(CHEMBL4461497)
Affinity DataIC50: 60nMAssay Description:Inhibition of recombinant human 10His-tagged eIF4E expressed in Escherichia coli BL21 (DE3) cells by catalytic enzyme-linked click chemistry assayMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50597681(CHEMBL5197975)
Affinity DataIC50: 79nMAssay Description:Inhibition of phosphorylation of eIF4E (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
LigandPNGBDBM50386775(CHEMBL2046916)
Affinity DataIC50: 95nMAssay Description:Competitive inhibition of [3H]m7-GTP binding to human FLAG-His6 tagged eIF4E expressed in Escherichia coli by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50386771(CHEMBL2046912)
Affinity DataIC50: 117nMAssay Description:Competitive inhibition of [3H]m7-GTP binding to human FLAG-His6 tagged eIF4E expressed in Escherichia coli by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50386768(CHEMBL2046908)
Affinity DataIC50: 125nMAssay Description:Competitive inhibition of [3H]m7-GTP binding to human FLAG-His6 tagged eIF4E expressed in Escherichia coli by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50386776(CHEMBL2046917)
Affinity DataIC50: 160nMAssay Description:Competitive inhibition of [3H]m7-GTP binding to human FLAG-His6 tagged eIF4E expressed in Escherichia coli by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50597677(CHEMBL5203734)
Affinity DataIC50: 200nMAssay Description:Inhibition of eIF4E (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
LigandPNGBDBM50520253(CHEMBL4587832)
Affinity DataIC50: 200nMAssay Description:Inhibition of eIF4E phosphorylation in human HeLa cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetEukaryotic translation initiation factor 4E(Rabbit)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50543775(CHEMBL4640985)
Affinity DataIC50: 280nMAssay Description:Inhibition of eIF4E in rabbit reticulocyte lysate system assessed as reduction in ARCA mRNA cap-dependent translation measured after 60 mins by lucif...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetEukaryotic translation initiation factor 4E(Rabbit)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50543775(CHEMBL4640985)
Affinity DataIC50: 280nMAssay Description:Inhibition of eIF4E in rabbit reticulocyte lysate system assessed as reduction in ARCA mRNA cap-dependent translation measured after 60 mins by lucif...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50170221(CHEMBL3806189)
Affinity DataIC50: 280nMAssay Description:Inhibition of eIF4E phosphorylation in human HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM375544(US9908886, Example 96 | 4-(6-(4-(morpholine-4-carb...)
Affinity DataIC50: 321nMAssay Description:Inhibition of eIF4E phosphorylation in human HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM297345(US10112955, Example 12 | N-(6-((1-oxoisoindolin-5-...)
Affinity DataIC50: 430nMAssay Description:Inhibition of phosphorylation of eIF4E (unknown origin) in HCT-116 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
LigandPNGBDBM167266(US9073881, 16 | US9073881, 15)
Affinity DataIC50: 500nMpH: 7.0Assay Description:Human eIF4E (aa 28-217) with a C-terminal His tag (HH-eIF4E) was expressed in E. coli in inclusion bodies. The protein was solubilized with 8 M urea ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetEukaryotic translation initiation factor 4E(Rabbit)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50110843(CHEMBL3604542)
Affinity DataIC50: 560nMAssay Description:Inhibition of eIF4E-mediated translation in flexi rabbit reticulocyte lysate using luciferase mRNA preincubated for 60 mins before mRNA addition by l...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEukaryotic translation initiation factor 4E(Rabbit)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50110843(CHEMBL3604542)
Affinity DataIC50: 560nMAssay Description:Inhibition of eIF4E-mediated translation in flexi rabbit reticulocyte lysate using luciferase mRNA treated simultaneously with mRNA by luminescence b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEukaryotic translation initiation factor 4E(Rabbit)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50294223(2-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-{[({[(pho...)
Affinity DataIC50: 560nMAssay Description:Inhibition of eukaryotic initiation factor 4E in micrococcal nuclease-pretreated rabbit reticulocyte lysate assessed as inhibition of m7,3'-O-GpppG-c...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEukaryotic translation initiation factor 4E(Rabbit)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50294223(2-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-{[({[(pho...)
Affinity DataIC50: 560nMAssay Description:Inhibition of eukaryotic initiation factor 4E in micrococcal nuclease-pretreated rabbit reticulocyte lysate assessed as inhibition of m7,3'-O-GpppG-c...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM167338(US9073881, 88)
Affinity DataIC50: 600nMpH: 7.0Assay Description:Human eIF4E (aa 28-217) with a C-terminal His tag (HH-eIF4E) was expressed in E. coli in inclusion bodies. The protein was solubilized with 8 M urea ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM167388(US9073881, 140)
Affinity DataIC50: 700nMpH: 7.0Assay Description:Human eIF4E (aa 28-217) with a C-terminal His tag (HH-eIF4E) was expressed in E. coli in inclusion bodies. The protein was solubilized with 8 M urea ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetEukaryotic translation initiation factor 4E(Rabbit)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50386762(CHEMBL2046906)
Affinity DataIC50: 700nMAssay Description:Inhibition of eIF4E in rabbit reticulocyte cell lysate assessed as inhibition of cap-dependent translation after 90 mins by luciferase reporter gene ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50613700(CHEMBL1234303 | CHEBI:50226)
Affinity DataIC50: 720nMAssay Description:Inhibition of P32-[alpha-GTP] cap radiolabelled RNA binding to recombinant eIF4E (unknown origin) assessed as decrease in cross linked RNA-eIF4E comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
LigandPNGBDBM167372(US9073881, 124)
Affinity DataIC50: 800nMpH: 7.0Assay Description:Human eIF4E (aa 28-217) with a C-terminal His tag (HH-eIF4E) was expressed in E. coli in inclusion bodies. The protein was solubilized with 8 M urea ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM167330(US9073881, 80)
Affinity DataIC50: 970nMpH: 7.0Assay Description:Human eIF4E (aa 28-217) with a C-terminal His tag (HH-eIF4E) was expressed in E. coli in inclusion bodies. The protein was solubilized with 8 M urea ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM167376(US9073881, 128)
Affinity DataIC50: 1.10E+3nMpH: 7.0Assay Description:Human eIF4E (aa 28-217) with a C-terminal His tag (HH-eIF4E) was expressed in E. coli in inclusion bodies. The protein was solubilized with 8 M urea ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM167392(US9073881, 144)
Affinity DataIC50: 1.10E+3nMpH: 7.0Assay Description:Human eIF4E (aa 28-217) with a C-terminal His tag (HH-eIF4E) was expressed in E. coli in inclusion bodies. The protein was solubilized with 8 M urea ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

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