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TargetBromodomain-containing protein 2(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50623606(CHEMBL5440537)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of BRD2 BD2 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
PubMed
TargetBromodomain-containing protein 2(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50623607(CHEMBL5440963)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of BRD2 BD2 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
PubMed
TargetBromodomain-containing protein 2(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50623611(CHEMBL5424952)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of BRD2 BD2 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
PubMed
TargetBromodomain-containing protein 2(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50623615(CHEMBL5432745)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of BRD2 BD2 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
PubMed
TargetBromodomain-containing protein 2(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM297163(US10112941, Example 279 | 2-{8-Fluoro-3-[4-(2H3)me...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of BRD2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBromodomain-containing protein 2(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50623605(CHEMBL5401253)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of BRD2 BD2 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
PubMed
TargetBromodomain-containing protein 2(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50623609(CHEMBL5436475)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of BRD2 BD2 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
PubMed
TargetBromodomain-containing protein 2(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50623610(CHEMBL5422881)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of BRD2 BD2 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
PubMed
TargetBromodomain-containing protein 2(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM439497(US10633379, Example 82 | US10633379, Example 35)
Affinity DataIC50: 0.920nMAssay Description:Inhibition of C-terminal His6-tagged BRD2 BD2 (unknown origin) using H-YSGRGK(Ac)GGK(Ac)GLGK(Ac)-GGAK(Ac)RHRK-Biotin-OH as substrate incubated for 1 ...More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 2(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50623615(CHEMBL5432745)
Affinity DataIC50: 1nMAssay Description:Inhibition of BRD2 BD1 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
PubMed
TargetBromodomain-containing protein 2(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50623602(CHEMBL5422163)
Affinity DataIC50: 1nMAssay Description:Inhibition of BRD2 BD2 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
PubMed
TargetBromodomain-containing protein 2(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM296947(US10112941, Example 54 | 2-[3-(Dimethyl-1H-1,2,3-t...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human BRD2 measured by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 2(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM296886(2-[3-(Dimethyl-1,2-oxazol-4-yl)-5-[oxan-4-yl(pheny...)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of human BRD2 measured by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 2(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50623612(CHEMBL5400310)
Affinity DataIC50: 2nMAssay Description:Inhibition of BRD2 BD2 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
PubMed
TargetBromodomain-containing protein 2(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50623613(CHEMBL5439607)
Affinity DataIC50: 2nMAssay Description:Inhibition of BRD2 BD2 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
PubMed
TargetBromodomain-containing protein 2(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50576438(CHEMBL4869149)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of recombinant human BRD2 BD2 (348 to 455 residues) expressed in bacterial expression system by bromoscan assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 2(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM192755(TG101209 | US11643396, Example TG101209 | US112797...)
Affinity DataIC50: 2.63nMAssay Description:AlphaScreen is a bead-based, non-radioactive Amplified Luminescent Proximity Homogeneous Assay. The details are not described in this patent.More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBromodomain-containing protein 2(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM313791(US10167292, Example 35)
Affinity DataIC50: 3nMAssay Description:Inhibition of human His-tagged Brd2 bromodomain 2 expressed in Escherichia coli BL21 (DE3) preincubated for 30 mins followed by addition of biotinyla...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 2(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50558065(CHEMBL4780530)
Affinity DataIC50: 3nMAssay Description:Inhibition of BRD2 BD1 (unknown origin) using biotinylated JQ1 analog as substrate measured after 20 mins by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 2(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50558065(CHEMBL4780530)
Affinity DataIC50: 3nMAssay Description:Inhibition of BRD2 BD2 (unknown origin) using biotinylated JQ1 analog as substrate measured after 20 mins by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 2(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50623606(CHEMBL5440537)
Affinity DataIC50: 3nMAssay Description:Inhibition of BRD2 BD1 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
PubMed
TargetBromodomain-containing protein 2(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50623611(CHEMBL5424952)
Affinity DataIC50: 3nMAssay Description:Inhibition of BRD2 BD1 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
PubMed
TargetBromodomain-containing protein 2(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50092312(Birabresib | MK-8628 | OTX-015)
Affinity DataIC50: 3nMAssay Description:Inhibition of BRD2 BD2 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBromodomain-containing protein 2(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50623604(CHEMBL5403848)
Affinity DataIC50: 3nMAssay Description:Inhibition of BRD2 BD2 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
PubMed
TargetBromodomain-containing protein 2(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50459819(CHEMBL4228445)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of FAM-labeled ZBA248 binding to recombinant N-terminal His6-tagged BRD2 bromodomain 1 (72 to 205 residues) (unknown origin) expressed in ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 2(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50028142(CHEMBL2177300)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of human BRD2 bromodomain 2 by BROMOscan assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 2(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50520653(CHEMBL4555209)
Affinity DataIC50: 3.5nMAssay Description:Binding affinity to human BRD2 BD1 (72 to 205 residues) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 2(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50459819(CHEMBL4228445)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of FAM-labeled ZBA248 binding to recombinant N-terminal His6-tagged BRD2 bromodomain 2 (349 to 460 residues) (unknown origin) expressed in...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 2(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50365262(CHEMBL1957266 | (S)-JQ1 (1) | US9320741, (S)-JQ1 |...)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of C-terminal His6-tagged BRD2 BD2 (unknown origin) using H-YSGRGK(Ac)GGK(Ac)GLGK(Ac)-GGAK(Ac)RHRK-Biotin-OH as substrate incubated for 1 ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBromodomain-containing protein 2(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM313789(US10167292, Example 33)
Affinity DataIC50: 4nMAssay Description:Inhibition of human His-tagged Brd2 bromodomain 2 expressed in Escherichia coli BL21 (DE3) preincubated for 30 mins followed by addition of biotinyla...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 2(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM543516(US11279703, TABLE 6.37 | US11279703, TABLE 6.199 |...)
Affinity DataIC50: 4.58nMAssay Description:AlphaScreen is a bead-based, non-radioactive Amplified Luminescent Proximity Homogeneous Assay. The details are not described in this patent.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails
US Patent

TargetBromodomain-containing protein 2(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50604624(CHEMBL5206088)
Affinity DataIC50: 5.10nMAssay Description:Inhibition of C-terminal His6-tagged BRD2 BD2 (unknown origin) using H-YSGRGK(Ac)GGK(Ac)GLGK(Ac)-GGAK(Ac)RHRK-Biotin-OH as substrate incubated for 1 ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBromodomain-containing protein 2(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50624343(CHEMBL5393744)
Affinity DataIC50: 5.90nMAssay Description:Inhibition of N-terminal his-tagged human recombinant BRD2 BD2 (2 to 473 residues) expressed in Escherichia coli by AlphaScreen assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
PubMed
TargetBromodomain-containing protein 2(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM313807(US10167292, Example 51B)
Affinity DataIC50: 6nMAssay Description:Inhibition of human His-tagged Brd2 bromodomain 1 expressed in Escherichia coli BL21 (DE3) preincubated for 30 mins followed by addition of biotinyla...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 2(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50365262(CHEMBL1957266 | (S)-JQ1 (1) | US9320741, (S)-JQ1 |...)
Affinity DataIC50: 6.70nMAssay Description:Inhibition of BRD2 BD2 (unknown origin) preincubated for 15 mins followed by peptide addition and measured after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 2(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM313807(US10167292, Example 51B)
Affinity DataIC50: 7nMAssay Description:Inhibition of human His-tagged Brd2 bromodomain 2 expressed in Escherichia coli BL21 (DE3) preincubated for 30 mins followed by addition of biotinyla...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 2(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50623602(CHEMBL5422163)
Affinity DataIC50: 8nMAssay Description:Inhibition of BRD2 BD1 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
PubMed
TargetBromodomain-containing protein 2(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM592507(US11572371, Compound 19)
Affinity DataIC50: 8.30nMAssay Description:Homogeneous time=resolved fluorescence (HTRF) was used to detect the binding of the compound to BRD4(D1 + D2) and BRDT (D1) proteins, and the AlphaSc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetBromodomain-containing protein 2(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50623607(CHEMBL5440963)
Affinity DataIC50: 9nMAssay Description:Inhibition of BRD2 BD1 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
PubMed
TargetBromodomain-containing protein 2(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50365262(CHEMBL1957266 | (S)-JQ1 (1) | US9320741, (S)-JQ1 |...)
Affinity DataIC50: 9nMAssay Description:Inhibition of BRD2 BD2 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBromodomain-containing protein 2(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50623608(CHEMBL5399489)
Affinity DataIC50: 9nMAssay Description:Inhibition of BRD2 BD2 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
PubMed
TargetBromodomain-containing protein 2(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50365262(CHEMBL1957266 | (S)-JQ1 (1) | US9320741, (S)-JQ1 |...)
Affinity DataIC50: 9.30nMAssay Description:Binding affinity to human partial length BRD2 BD2 (E348to D455 residues) expressed in bacterial expression system using H4K5acIC8acK12acK16ac-biotiny...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBromodomain-containing protein 2(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50576438(CHEMBL4869149)
Affinity DataIC50: 10nMAssay Description:Inhibition of 6His-Thr-BRD2 (1 to 473 residues) BD2 domain Y386A or Y113A mutant (unknown origin) incubated for 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 2(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50623613(CHEMBL5439607)
Affinity DataIC50: 10nMAssay Description:Inhibition of BRD2 BD1 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
PubMed
TargetBromodomain-containing protein 2(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM592405(US11572371, Compound 20)
Affinity DataIC50: 10.1nMAssay Description:Homogeneous time=resolved fluorescence (HTRF) was used to detect the binding of the compound to BRD4(D1 + D2) and BRDT (D1) proteins, and the AlphaSc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetBromodomain-containing protein 2(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM592508(US11572371, Compound 22)
Affinity DataIC50: 10.8nMAssay Description:Homogeneous time=resolved fluorescence (HTRF) was used to detect the binding of the compound to BRD4(D1 + D2) and BRDT (D1) proteins, and the AlphaSc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetBromodomain-containing protein 2(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM318840(US9624247, Example 2 | (R)-6-4-chlorophenyl)-3-cyc...)
Affinity DataIC50: 11nMAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetBromodomain-containing protein 2(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM318855(US9624247, Example 17 | (R)-6-(4-chlorophenyl)-3-c...)
Affinity DataIC50: 11nMAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetBromodomain-containing protein 2(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM318861(US9624247, Example 24 | (R)-6-(4-chlorophenyl)-3-c...)
Affinity DataIC50: 11nMAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetBromodomain-containing protein 2(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM380670(US9890166, Example 57 | 6-(4-chlorophenyl)-2-cyclo...)
Affinity DataIC50: 11nMAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

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