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Report error Found 454 of ic50 data for polymerid = 6477
TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM374727(US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...)
Affinity DataIC50: 0.0100nMAssay Description:Inhibition of TrKC (unknown origin) incubated for 120 mins in presence of 33P-ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM374727(US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human TRKC using poly[Glu:Tyr] (4:1) as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM374727(US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of TRKC (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 0.123nMAssay Description:Inhibition of human TRKC using poly[Glu:Tyr] (4:1) as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM50581357(CHEMBL5093999)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of TrKC (unknown origin) incubated for 120 mins in presence of 33P-ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM50581355(CHEMBL5070835)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of TrKC (unknown origin) incubated for 120 mins in presence of 33P-ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM50581356(CHEMBL5080010)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of TrKC (unknown origin) incubated for 120 mins in presence of 33P-ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM136597(US8865698, 14 | US10047097, 14 | US9676783, 14 | U...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of TRKC (unknown origin) using TK as substrate in presence of ATP incubated for 40 mins by HTRF KinEASE assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM50579500(CHEMBL4864729)
Affinity DataIC50: 0.210nMAssay Description:Inhibition of TRKC (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM50631772(CHEMBL5400169)
Affinity DataIC50: 0.211nMAssay Description:Inhibition of His-tagged human recombinant wild type TRKCMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 0.220nMAssay Description:Inhibition of human TRKC using poly[Glu:Tyr] (4:1) as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM136597(US8865698, 14 | US10047097, 14 | US9676783, 14 | U...)
Affinity DataIC50: 0.290nMAssay Description:Kinase assay: After the buffer was prepared, the enzyme was mixed with different concentrations of the compound prepared by pre-diluting, and allowed...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM136597(US8865698, 14 | US10047097, 14 | US9676783, 14 | U...)
Affinity DataIC50: 0.290nMAssay Description:Kinase assay: After the buffer was prepared, the enzyme was mixed with different concentrations of the compound prepared by pre-diluting, and allowed...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM136597(US8865698, 14 | US10047097, 14 | US9676783, 14 | U...)
Affinity DataIC50: 0.320nMAssay Description:Kinase assay: After the buffer was prepared, the enzyme was mixed with different concentrations of the compound prepared by pre-diluting, and allowed...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM136597(US8865698, 14 | US10047097, 14 | US9676783, 14 | U...)
Affinity DataIC50: 0.410nMAssay Description:Kinase assay: After the buffer was prepared, the enzyme was mixed with different concentrations of the compound prepared by pre-diluting, and allowed...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM136597(US8865698, 14 | US10047097, 14 | US9676783, 14 | U...)
Affinity DataIC50: 0.440nMAssay Description:Kinase assay: After the buffer was prepared, the enzyme was mixed with different concentrations of the compound prepared by pre-diluting, and allowed...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM136597(US8865698, 14 | US10047097, 14 | US9676783, 14 | U...)
Affinity DataIC50: 0.450nMAssay Description:Kinase assay: After the buffer was prepared, the enzyme was mixed with different concentrations of the compound prepared by pre-diluting, and allowed...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM50507492(Loxo-195 | Selitrectinib | US10966985, Compound 33...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of TrKC (unknown origin) incubated for 120 mins in presence of 33P-ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM164901(US9067914, Ex. 3-15 | US10166239, Ex. 3-15 | US114...)
Affinity DataIC50: 0.503nMAssay Description:Human TrkC, catalytic domain [456-825(end) amino acids of accession number NP-002521.2] was expressed as N-terminal GST-fusion protein (69 kDa) using...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM164901(US9067914, Ex. 3-15 | US10166239, Ex. 3-15 | US114...)
Affinity DataIC50: 0.503nMAssay Description:Human TrkC, catalytic domain [456-825(end) amino acids of accession number NP_002521.2] was expressed as N-terminal GST-fusion protein (69 kDa) using...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM164901(US9067914, Ex. 3-15 | US10166239, Ex. 3-15 | US114...)
Affinity DataIC50: 0.503nMAssay Description:Human TrkC, catalytic domain [456-825(end) amino acids of accession number NP_002521.2] was expressed as N-terminal GST-fusion protein (69 kDa) using...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM164901(US9067914, Ex. 3-15 | US10166239, Ex. 3-15 | US114...)
Affinity DataIC50: 0.503nMAssay Description:Human TrkC, catalytic domain [456-825 (end) amino acids of accession number NP_002521.2] was expressed as N-terminal GST-fusion protein (69 kDa) usin...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 0.525nMpH: 7.5Assay Description:Compounds to be tested were dissolved in 100% DMSO in a range of concentrations from 10-8 to 10-3 M including negative control (DMSO), then diluted w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM374727(US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...)
Affinity DataIC50: 0.550nMMore data for this Ligand-Target Pair
In DepthDetails

TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGUS12129258, Example 1(US20240132517, Comparative Compound 42)
Affinity DataIC50: 0.610nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM702000(US12129258, Example 23)
Affinity DataIC50: 0.630nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM50601440(CHEMBL5176837)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of TrkC (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM701998(US12129258, Example 13)
Affinity DataIC50: 0.730nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM702001(US12129258, Example 24)
Affinity DataIC50: 0.75nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM702002(US12129258, Example 9)
Affinity DataIC50: 0.760nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM50193395(Altiratinib | DCC-2701 | DP-5164)
Affinity DataIC50: 0.830nMAssay Description:Inhibition of TrkC (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM50092079(CHEMBL3582439)
Affinity DataIC50: 1nMAssay Description:Inhibition of Tel-fused TRKC (unknown origin) overexpressed in mouse BA/F3 cells assessed as inhibition of cell proliferation after 48 hrs by lucifer...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM50092082(CHEMBL3582441)
Affinity DataIC50: 1nMAssay Description:Inhibition of Tel-fused TRKC (unknown origin) overexpressed in mouse BA/F3 cells assessed as inhibition of cell proliferation after 48 hrs by lucifer...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM50457839(CHEMBL4211921)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at prolink-tagged TrkC in human U2OS cells assessed as inhibition of NT3-induced receptor phosphorylation by measuring reduction ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM472735(2-amino-5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-...)
Affinity DataIC50: 1nMAssay Description:TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM472759(2-amino-5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoro...)
Affinity DataIC50: 1nMAssay Description:TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM472762(2-amino-5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoro...)
Affinity DataIC50: 1nMAssay Description:TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM50550243(CHEMBL4790022)
Affinity DataIC50: 1nMAssay Description:Inhibition of human TrkC expressed in human U2OS cells pre-incubated 30 mins before neurotrophin addition and measured after 2 hrs by luminescence ba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
PubMed
TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM134787(US8846698, 250)
Affinity DataIC50: 1nMAssay Description:Inhibition of human TrkC expressed in human U2OS cells pre-incubated 30 mins before neurotrophin addition and measured after 2 hrs by luminescence ba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM158154(US9029356, 11 | US9255087, 11 | US10081622, Compou...)
Affinity DataIC50: 1nMAssay Description:Kinase assay: After the buffer was prepared, the enzyme was mixed with different concentrations of pre-diluted compounds in duplex, and allowed to st...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM158154(US9029356, 11 | US9255087, 11 | US10081622, Compou...)
Affinity DataIC50: 1nMAssay Description:Kinase assay: After the buffer was prepared, the enzyme was mixed with different concentrations of pre-diluted compounds in duplex, and allowed to st...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM158154(US9029356, 11 | US9255087, 11 | US10081622, Compou...)
Affinity DataIC50: 1nMAssay Description:Kinase assay: After the buffer was prepared, the enzyme was mixed with different concentrations of pre-diluted compounds in duplex, and allowed to st...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM158154(US9029356, 11 | US9255087, 11 | US10081622, Compou...)
Affinity DataIC50: 1nMAssay Description:Kinase assay: After the buffer was prepared, the enzyme was mixed with different concentrations of pre-diluted compounds in duplex, and allowed to st...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM158154(US9029356, 11 | US9255087, 11 | US10081622, Compou...)
Affinity DataIC50: 1nMAssay Description:Kinase assay: After the buffer was prepared, the enzyme was mixed with different concentrations of pre-diluted compounds in duplex, and allowed to st...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM158154(US9029356, 11 | US9255087, 11 | US10081622, Compou...)
Affinity DataIC50: 1nMAssay Description:Kinase assay: After the buffer was prepared, the enzyme was mixed with different concentrations of pre-diluted compounds in duplex, and allowed to st...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM158154(US9029356, 11 | US9255087, 11 | US10081622, Compou...)
Affinity DataIC50: 1nMAssay Description:Kinase assay: After the buffer was prepared, the enzyme was mixed with different concentrations of pre-diluted compounds in duplex, and allowed to st...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM158154(US9029356, 11 | US9255087, 11 | US10081622, Compou...)
Affinity DataIC50: 1nMAssay Description:Kinase assay: After the buffer was prepared, the enzyme was mixed with different concentrations of pre-diluted compounds in duplex, and allowed to st...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM158154(US9029356, 11 | US9255087, 11 | US10081622, Compou...)
Affinity DataIC50: 1nMAssay Description:Kinase assay: After the buffer was prepared, the enzyme was mixed with different concentrations of pre-diluted compounds in duplex, and allowed to st...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM158154(US9029356, 11 | US9255087, 11 | US10081622, Compou...)
Affinity DataIC50: 1nMAssay Description:Kinase assay: After the buffer was prepared, the enzyme was mixed with different concentrations of pre-diluted compounds in duplex, and allowed to st...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetNT-3 growth factor receptor(Human)
Yantai University

Curated by ChEMBL
LigandPNGBDBM158154(US9029356, 11 | US9255087, 11 | US10081622, Compou...)
Affinity DataIC50: 1nMAssay Description:Kinase assay: After the buffer was prepared, the enzyme was mixed with different concentrations of pre-diluted compounds in duplex, and allowed to st...More data for this Ligand-Target Pair
In DepthDetails
US Patent

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