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Report error Found 1579 of ic50 data for polymerid = 642,735
TargetTyrosine-protein kinase JAK2 [828-1132](Human)
Incyte

US Patent
LigandPNGBDBM197716(US9216984, 1)
Affinity DataIC50: 0.260nMpH: 7.8 T: 2°CAssay Description:The compounds of the invention were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al.,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK2 [828-1132](Human)
Incyte

US Patent
LigandPNGBDBM197716(US9216984, 1)
Affinity DataIC50: 0.290nMpH: 7.8 T: 2°CAssay Description:The compounds of the invention were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al.,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK2 [828-1132](Human)
Incyte

US Patent
LigandPNGBDBM197717(US9216984, 2)
Affinity DataIC50: 0.300nMpH: 7.8 T: 2°CAssay Description:The compounds of the invention were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al.,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK2 [828-1132](Human)
Incyte

US Patent
LigandPNGBDBM197717(US9216984, 2)
Affinity DataIC50: 0.650nMpH: 7.8 T: 2°CAssay Description:The compounds of the invention were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al.,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM663841(US20240109915, Example 22)
Affinity DataIC50: 0.900nMAssay Description:The ACC inhibitory activity of the compounds of the present invention was demonstrated by methods based on standard procedures. The direct inhibition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM663852(US20240109915, Example 34)
Affinity DataIC50: 1.30nMAssay Description:The ACC inhibitory activity of the compounds of the present invention was demonstrated by methods based on standard procedures. The direct inhibition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM663855(US20240109915, Example 37)
Affinity DataIC50: 1.30nMAssay Description:The ACC inhibitory activity of the compounds of the present invention was demonstrated by methods based on standard procedures. The direct inhibition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK2 [828-1132](Human)
Incyte

US Patent
LigandPNGBDBM197717(US9216984, 2)
Affinity DataIC50: 1.40nMpH: 7.8 T: 2°CAssay Description:The compounds of the invention were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al.,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM663858(US20240109915, Example 40)
Affinity DataIC50: 1.5nMAssay Description:The ACC inhibitory activity of the compounds of the present invention was demonstrated by methods based on standard procedures. The direct inhibition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM663912(US20240109915, Example 97)
Affinity DataIC50: 1.80nMAssay Description:The ACC inhibitory activity of the compounds of the present invention was demonstrated by methods based on standard procedures. The direct inhibition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK2 [828-1132](Human)
Incyte

US Patent
LigandPNGBDBM197716(US9216984, 1)
Affinity DataIC50: 2.20nMpH: 7.8 T: 2°CAssay Description:The compounds of the invention were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al.,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM663833(US20240109915, Example 14)
Affinity DataIC50: 2.20nMAssay Description:The ACC inhibitory activity of the compounds of the present invention was demonstrated by methods based on standard procedures. The direct inhibition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM663869(US20240109915, Example 52)
Affinity DataIC50: 2.40nMAssay Description:The ACC inhibitory activity of the compounds of the present invention was demonstrated by methods based on standard procedures. The direct inhibition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM663907(US20240109915, Example 92)
Affinity DataIC50: 2.40nMAssay Description:The ACC inhibitory activity of the compounds of the present invention was demonstrated by methods based on standard procedures. The direct inhibition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM663853(US20240109915, Example 35)
Affinity DataIC50: 2.60nMAssay Description:The ACC inhibitory activity of the compounds of the present invention was demonstrated by methods based on standard procedures. The direct inhibition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM663843(US20240109915, Example 24)
Affinity DataIC50: 3.10nMAssay Description:The ACC inhibitory activity of the compounds of the present invention was demonstrated by methods based on standard procedures. The direct inhibition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM663860(US20240109915, Example 42)
Affinity DataIC50: 3.10nMAssay Description:The ACC inhibitory activity of the compounds of the present invention was demonstrated by methods based on standard procedures. The direct inhibition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM663915(US20240109915, Example 100)
Affinity DataIC50: 3.10nMAssay Description:The ACC inhibitory activity of the compounds of the present invention was demonstrated by methods based on standard procedures. The direct inhibition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM663837(US20240109915, Example 18)
Affinity DataIC50: 3.20nMAssay Description:The ACC inhibitory activity of the compounds of the present invention was demonstrated by methods based on standard procedures. The direct inhibition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM663834(US20240109915, Example 15)
Affinity DataIC50: 3.40nMAssay Description:The ACC inhibitory activity of the compounds of the present invention was demonstrated by methods based on standard procedures. The direct inhibition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM663850(US20240109915, Example 32)
Affinity DataIC50: 3.5nMAssay Description:The ACC inhibitory activity of the compounds of the present invention was demonstrated by methods based on standard procedures. The direct inhibition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM663871(US20240109915, Example 55)
Affinity DataIC50: 3.5nMAssay Description:The ACC inhibitory activity of the compounds of the present invention was demonstrated by methods based on standard procedures. The direct inhibition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM663840(US20240109915, Example 21)
Affinity DataIC50: 3.60nMAssay Description:The ACC inhibitory activity of the compounds of the present invention was demonstrated by methods based on standard procedures. The direct inhibition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM663878(US20240109915, Example 62)
Affinity DataIC50: 3.60nMAssay Description:The ACC inhibitory activity of the compounds of the present invention was demonstrated by methods based on standard procedures. The direct inhibition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM663883(US20240109915, Example 68)
Affinity DataIC50: 3.90nMAssay Description:The ACC inhibitory activity of the compounds of the present invention was demonstrated by methods based on standard procedures. The direct inhibition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM663914(US20240109915, Example 99)
Affinity DataIC50: 3.90nMAssay Description:The ACC inhibitory activity of the compounds of the present invention was demonstrated by methods based on standard procedures. The direct inhibition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM663849(US20240109915, Example 31)
Affinity DataIC50: 4nMAssay Description:The ACC inhibitory activity of the compounds of the present invention was demonstrated by methods based on standard procedures. The direct inhibition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM663894(US20240109915, Example 79)
Affinity DataIC50: 4.10nMAssay Description:The ACC inhibitory activity of the compounds of the present invention was demonstrated by methods based on standard procedures. The direct inhibition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM663877(US20240109915, Example 61)
Affinity DataIC50: 4.40nMAssay Description:The ACC inhibitory activity of the compounds of the present invention was demonstrated by methods based on standard procedures. The direct inhibition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM663830(US20240109915, Example 11)
Affinity DataIC50: 4.5nMAssay Description:The ACC inhibitory activity of the compounds of the present invention was demonstrated by methods based on standard procedures. The direct inhibition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM663848(US20240109915, Example 30)
Affinity DataIC50: 4.60nMAssay Description:The ACC inhibitory activity of the compounds of the present invention was demonstrated by methods based on standard procedures. The direct inhibition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM663885(US20240109915, Example 70)
Affinity DataIC50: 4.60nMAssay Description:The ACC inhibitory activity of the compounds of the present invention was demonstrated by methods based on standard procedures. The direct inhibition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM663856(US20240109915, Example 38)
Affinity DataIC50: 4.90nMAssay Description:The ACC inhibitory activity of the compounds of the present invention was demonstrated by methods based on standard procedures. The direct inhibition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK2 [828-1132](Human)
Incyte

US Patent
LigandPNGBDBM400481(US9999619, Example 236 | US10695337, Example 236 |...)
Affinity DataIC50: 5nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK2 [828-1132](Human)
Incyte

US Patent
LigandPNGBDBM400486({1-[8-(2-Chloro-3,6-difluorobenzyl)-8-azabicyclo[3...)
Affinity DataIC50: 5nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK2 [828-1132](Human)
Incyte

US Patent
LigandPNGBDBM400491(US9999619, Example 247 | US10695337, Example 247 |...)
Affinity DataIC50: 5nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK2 [828-1132](Human)
Incyte

US Patent
LigandPNGBDBM400495(US9999619, Example 251 | US10695337, Example 251 |...)
Affinity DataIC50: 5nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK2 [828-1132](Human)
Incyte

US Patent
LigandPNGBDBM400497(US9999619, Example 253 | US10695337, Example 253 |...)
Affinity DataIC50: 5nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK2 [828-1132](Human)
Incyte

US Patent
LigandPNGBDBM400502(US9999619, Example 258 | US10695337, Example 258 |...)
Affinity DataIC50: 5nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK2 [828-1132](Human)
Incyte

US Patent
LigandPNGBDBM400503(US9999619, Example 259 | US10695337, Example 259 |...)
Affinity DataIC50: 5nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK2 [828-1132](Human)
Incyte

US Patent
LigandPNGBDBM400514(US9999619, Example 270 | US10695337, Example 270 |...)
Affinity DataIC50: 5nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK2 [828-1132](Human)
Incyte

US Patent
LigandPNGBDBM400517(US9999619, Example 273 | US10695337, Example 273)
Affinity DataIC50: 5nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK2 [828-1132](Human)
Incyte

US Patent
LigandPNGBDBM400520(US9999619, Example 276 | US10695337, Example 276 |...)
Affinity DataIC50: 5nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK2 [828-1132](Human)
Incyte

US Patent
LigandPNGBDBM400522(US9999619, Example 278 | US10695337, Example 278 |...)
Affinity DataIC50: 5nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK2 [828-1132](Human)
Incyte

US Patent
LigandPNGBDBM400523(US9999619, Example 279 | US10695337, Example 279 |...)
Affinity DataIC50: 5nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK2 [828-1132](Human)
Incyte

US Patent
LigandPNGBDBM400524(US9999619, Example 280 | US10695337, Example 280 |...)
Affinity DataIC50: 5nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK2 [828-1132](Human)
Incyte

US Patent
LigandPNGBDBM400532(US9999619, Example 288 | US10695337, Example 288 |...)
Affinity DataIC50: 5nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK2 [828-1132](Human)
Incyte

US Patent
LigandPNGBDBM400541(US9999619, Example 297 | US10695337, Example 297 |...)
Affinity DataIC50: 5nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK2 [828-1132](Human)
Incyte

US Patent
LigandPNGBDBM400566(US9999619, Example 322 | US10695337, Example 322 |...)
Affinity DataIC50: 5nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetTyrosine-protein kinase JAK2 [828-1132](Human)
Incyte

US Patent
LigandPNGBDBM400567(US9999619, Example 323 | US10695337, Example 323 |...)
Affinity DataIC50: 5nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

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