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Report error Found 53 of ic50 data for polymerid = 5427,50000873
TargetEphrin type-B receptor 3(Human)
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Curated by ChEMBL
LigandPNGBDBM50598829(CHEMBL5203261)
Affinity DataIC50: 7nMAssay Description:Inhibition of full length Nano-luc fused EPHB3 in human HEK-293T cells incubated for 2 hrs by cell based NanoBRET target engagement assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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PubMed
TargetEphrin type-B receptor 3(Human)
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Curated by ChEMBL
LigandPNGBDBM50598820(CHEMBL5191665)
Affinity DataIC50: 7nMAssay Description:Inhibition of full length Nano-luc fused EPHB3 in human HEK-293T cells incubated for 2 hrs by cell based NanoBRET target engagement assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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PubMed
TargetEphrin type-B receptor 3(Human)
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Curated by ChEMBL
LigandPNGBDBM50100316(CHEMBL3321809)
Affinity DataIC50: 7nMAssay Description:Inhibition of full length Nano-luc fused EPHB3 in human HEK-293T cells incubated for 2 hrs by cell based NanoBRET target engagement assayMore data for this Ligand-Target Pair
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PubMed
TargetEphrin type-B receptor 3(Human)
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Curated by ChEMBL
LigandPNGBDBM50299218(Cpd66 | 8-(2-Methoxyphenyl)-1-methyl-7-(2'-methyl-...)
Affinity DataIC50: 15nMAssay Description:Inhibition of EphB3 by [gamma33-P]ATP based assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-B receptor 3(Human)
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Curated by ChEMBL
LigandPNGBDBM50598810(CHEMBL5202826)
Affinity DataIC50: 18nMAssay Description:Inhibition of full length Nano-luc fused EPHB3 in human HEK-293T cells incubated for 2 hrs by cell based NanoBRET target engagement assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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PubMed
TargetEphrin type-B receptor 3(Human)
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Curated by ChEMBL
LigandPNGBDBM50538442(CHEMBL4638981)
Affinity DataIC50: 20nMAssay Description:Inhibition of EPHB3 (unknown origin) assessed as residual activity incubated for 5 mins in presence of [gamma-33ATP] by scintillation counting based ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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PubMed
TargetEphrin type-B receptor 3(Human)
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Curated by ChEMBL
LigandPNGBDBM50538438(CHEMBL4640297)
Affinity DataIC50: 51nMAssay Description:Inhibition of EPHB3 (unknown origin) assessed as residual activity incubated for 5 mins in presence of [gamma-33ATP] by scintillation counting based ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetEphrin type-B receptor 3(Human)
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Curated by ChEMBL
LigandPNGBDBM50311312(N-(2-chlorophenyl)-6-phenylimidazo[1,2-a]pyridine-...)
Affinity DataIC50: 60nMAssay Description:Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-B receptor 3(Human)
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Curated by ChEMBL
LigandPNGBDBM50311306(N-(2-chlorophenyl)-5-(piperidin-1-yl)pyrazolo[1,5-...)
Affinity DataIC50: 63nMAssay Description:Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-B receptor 3(Human)
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Curated by ChEMBL
LigandPNGBDBM50311302(N-(2-chlorophenyl)-5-phenylpyrazolo[1,5-a]pyridine...)
Affinity DataIC50: 66nMAssay Description:Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...More data for this Ligand-Target Pair
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PubMed
TargetEphrin type-B receptor 3(Human)
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Curated by ChEMBL
LigandPNGBDBM50311303(N-(2-chlorophenyl)-5-(dimethylamino)pyrazolo[1,5-a...)
Affinity DataIC50: 77nMAssay Description:Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...More data for this Ligand-Target Pair
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PubMed
TargetEphrin type-B receptor 3(Human)
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Curated by ChEMBL
LigandPNGBDBM50311316(LDN-211904 | N-(2-chlorophenyl)-6-(piperidin-4-yl)...)
Affinity DataIC50: 79nMAssay Description:Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...More data for this Ligand-Target Pair
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PubMed
TargetEphrin type-B receptor 3(Human)
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Curated by ChEMBL
LigandPNGBDBM50311313(N-(2-chlorophenyl)-6-(piperidin-1-yl)imidazo[1,2-a...)
Affinity DataIC50: 87nMAssay Description:Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...More data for this Ligand-Target Pair
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PubMed
TargetEphrin type-B receptor 3(Human)
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Curated by ChEMBL
LigandPNGBDBM50311318(6-bromo-N-(2-chlorophenyl)-2-methylimidazo[1,2-a]p...)
Affinity DataIC50: 173nMAssay Description:Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-B receptor 3(Human)
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Curated by ChEMBL
LigandPNGBDBM50311301(N-(2-chlorophenyl)-5-methoxypyrazolo[1,5-a]pyridin...)
Affinity DataIC50: 190nMAssay Description:Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-B receptor 3(Human)
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Curated by ChEMBL
LigandPNGBDBM50311304(N-(2-chlorophenyl)-5-(1H-pyrrol-1-yl)pyrazolo[1,5-...)
Affinity DataIC50: 200nMAssay Description:Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...More data for this Ligand-Target Pair
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PubMed
TargetEphrin type-B receptor 3(Human)
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Curated by ChEMBL
LigandPNGBDBM50311317(N-(2-chlorophenyl)-6-(4-hydroxypiperidin-4-yl)imid...)
Affinity DataIC50: 228nMAssay Description:Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...More data for this Ligand-Target Pair
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PubMed
TargetEphrin type-B receptor 3(Human)
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Curated by ChEMBL
LigandPNGBDBM50311305(N-(2-chlorophenyl)-5-morpholinopyrazolo[1,5-a]pyri...)
Affinity DataIC50: 240nMAssay Description:Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-B receptor 3(Human)
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Curated by ChEMBL
LigandPNGBDBM50311296(N-(2-chlorophenyl)-5-methylpyrazolo[1,5-a]pyridine...)
Affinity DataIC50: 260nMAssay Description:Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-B receptor 3(Human)
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Curated by ChEMBL
LigandPNGBDBM50357333(CHEMBL1916891)
Affinity DataIC50: 350nMAssay Description:Inhibition of EPHB3 relative to controlMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-B receptor 3(Human)
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Curated by ChEMBL
LigandPNGBDBM50311311(N-(2-chlorophenyl)imidazo[1,2-a]pyridine-3-carboxa...)
Affinity DataIC50: 460nMAssay Description:Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-B receptor 3(Human)
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Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 741nMAssay Description:Inhibition of human EPHB3 using poly[Glu:Tyr] (4:1) as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-B receptor 3(Human)
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Curated by ChEMBL
LigandPNGBDBM50311288(N-(2-chlorophenyl)pyrazolo[1,5-a]pyridine-3-carbox...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-B receptor 3(Human)
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Curated by ChEMBL
LigandPNGBDBM50363957(CHEMBL1952210)
Affinity DataIC50: 1.09E+3nMAssay Description:Inhibition of EphB3More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-B receptor 3(Human)
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Curated by ChEMBL
LigandPNGBDBM50182212(7-(4-fluorophenylamino)-1-((1S,3R)-3-hydroxycyclop...)
Affinity DataIC50: 1.25E+3nMAssay Description:Inhibitory activity against EphB3More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetEphrin type-B receptor 3(Human)
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 1.83E+3nMAssay Description:Inhibition of human EPHB3 using poly[Glu:Tyr] (4:1) as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-B receptor 3(Human)
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Curated by ChEMBL
LigandPNGBDBM50311299(5-chloro-N-(2-chlorophenyl)pyrazolo[1,5-a]pyridine...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-B receptor 3(Human)
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50134791(CHEMBL3734863)
Affinity DataIC50: 3.90E+3nMAssay Description:Displacement of biotinylated ephrin-B1-Fc from EphB3 (unknown origin) preincubated for 1 hr followed by biotinylated-ephrin-B1-Fc addition measured a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-B receptor 3(Human)
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Curated by ChEMBL
LigandPNGBDBM50428059(CHEMBL2322989)
Affinity DataIC50: 4.40E+3nMAssay Description:Displacement of ephrin-B1-Fc from EphB3 receptor Fc ectodomain (unknown origin) after 1 hr by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-B receptor 3(Human)
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Curated by ChEMBL
LigandPNGBDBM13533(1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...)
Affinity DataIC50: 9.40E+3nMAssay Description:Inhibition of EPHB3More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-B receptor 3(Human)
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50519662(CHEMBL4438748)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human EphB3 (599 to 920 residues) using poly(Glu, Tyr) 4:1 as substrate after 40 mins in presence of [gamma-33ATP] by radio...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-B receptor 3(Human)
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Curated by ChEMBL
LigandPNGBDBM50135286(CHEMBL3745885)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human EPHB3 using poly[Glu:Tyr] (4:1) as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-B receptor 3(Mouse)
University of Parma

Curated by ChEMBL
LigandPNGBDBM50551201(CHEMBL4761556)
Affinity DataIC50: 1.10E+4nMAssay Description:Displacement of biotinylated ephrin-B1-Fc from mouse EphB3 Fc preincubated for 1 hr followed by ephrin-B1-FC addition and measured after 4 hrs by ELI...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-B receptor 3(Human)
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50311310(N-(2-chlorophenyl)pyrazolo[1,5-a]pyrazine-3-carbox...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-B receptor 3(Human)
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50311295(N-(2-chlorophenyl)-4-methylpyrazolo[1,5-a]pyridine...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-B receptor 3(Human)
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50311297(N-(2-chlorophenyl)-6-methylpyrazolo[1,5-a]pyridine...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-B receptor 3(Human)
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50618607(CHEMBL5425418)
Affinity DataIC50: 1.83E+4nMAssay Description:Inhibition of full length NanoLuc fused EPHB3 (unknown origin) transfected in HEK293T cells using NanoBRET NanoGlo substrate incubated for 2 hrs in p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetEphrin type-B receptor 3(Human)
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Curated by ChEMBL
LigandPNGBDBM50311309(N-(2-chlorophenyl)-[1,2,3]triazolo[1,5-a]pyridine-...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...More data for this Ligand-Target Pair
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PubMed
TargetEphrin type-B receptor 3(Human)
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Curated by ChEMBL
LigandPNGBDBM50311308(N-(2-chlorophenyl)-1H-indazole-3-carboxamide | CHE...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-B receptor 3(Human)
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Curated by ChEMBL
LigandPNGBDBM50311307(5-(benzyloxy)-N-(2-chlorophenyl)pyrazolo[1,5-a]pyr...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-B receptor 3(Human)
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50311300(6-chloro-N-(2-chlorophenyl)pyrazolo[1,5-a]pyridine...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-B receptor 3(Human)
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50311298(4-chloro-N-(2-chlorophenyl)pyrazolo[1,5-a]pyridine...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-B receptor 3(Human)
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50311314(N-(2-methoxyphenyl)-6-phenylimidazo[1,2-a]pyridine...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-B receptor 3(Human)
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50311294(2-chloro-N-(pyrazolo[1,5-a]pyridin-3-ylmethyl)anil...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-B receptor 3(Human)
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Curated by ChEMBL
LigandPNGBDBM50311293(2-chloro-N-(pyrazolo[1,5-a]pyridin-3-yl)benzamide ...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-B receptor 3(Human)
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50311292(N-(2-cyanophenyl)pyrazolo[1,5-a]pyridine-3-carboxa...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-B receptor 3(Human)
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Curated by ChEMBL
LigandPNGBDBM50311291(N-(2-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridi...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-B receptor 3(Human)
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50311290(N-(2,3-dichlorophenyl)pyrazolo[1,5-a]pyridine-3-ca...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-B receptor 3(Human)
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50311289(N-(2-fluorophenyl)pyrazolo[1,5-a]pyridine-3-carbox...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-B receptor 3(Human)
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50311315(N-(2-chlorophenyl)-2-methyl-6-phenylimidazo[1,2-a]...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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